Patents by Inventor Martin R. Graf

Martin R. Graf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical composition for cancer treatment containing cells that express a membrane cytokine
    Patent number: 7364726
    Abstract: This invention comprises cellular vaccines and methods of using them in cancer immunotherapy, particularly in humans. The vaccines comprise a source of tumor-associated antigen, and a cytokine-secreting cell line. Tumor antigen may be provided in the form of primary tumor cells, tumor cell lines or tumor extracts prepared from the subject. In certain embodiments of the invention, the cytokine-secreting line is a separate tumor line that is allogeneic to the patient and genetically altered so as to produce a cytokine at an elevated level. Exemplary cytokines are IL-4, GM-CSF, IL-2, TNF-?, and M-CSF in the secreted or membrane-bound form. In these embodiments, the cytokine-producing cells provide immunostimulation in trans to generate a specific immune response against the tumor antigen.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: April 29, 2008
    Assignee: The Regents of the University of California
    Inventors: John C. Hiserodt, Martin R. Graf, Gale A. Granger
  • Cancer immunotherapy using autologous tumor cells combined with cells expressing a membrane cytokline
    Patent number: 7264820
    Abstract: This invention comprises cellular vaccines and methods of using them in cancer immunotherapy, particularly in humans. The vaccines comprise a source of tumor-associated antigen, and a cytokine-secreting cell line. Tumor antigen may be provided in the form of primary tumor cells, tumor cell lines or tumor extracts prepared from the subject. In certain embodiments of the invention, the cytokine-secreting line is a separate tumor line that is allogeneic to the patient and genetically altered so as to produce a cytokine at an elevated level. Exemplary cytokines are IL-4, GM-CSF, IL-2, TNF-?, and M-CSF in the secreted or membrane-bound form. In these embodiments, the cytokine-producing cells provide immunostimulation in trans to generate a specific immune response against the tumor antigen.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: September 4, 2007
    Assignee: The Regents of the University of California
    Inventors: John C. Hiserodt, Martin R. Graf, Gale A. Granger
  • Cancer immunotherapy using autologous tumor cells combined with cells expressing a membrane cytokine
    Publication number: 20010038841
    Abstract: This invention comprises cellular vaccines and methods of using them in cancer immunotherapy, particularly in humans. The vaccines comprise a source of tumor-associated antigen, and a cytokine-secreting cell line. Tumor antigen may be provided in the form of primary tumor cells, tumor cell lines or tumor extracts prepared from the subject. In certain embodiments of the invention, the cytokine-secreting line is a separate tumor line that is allogeneic to the patient and genetically altered so as to produce a cytokine at an elevated level. Exemplary cytokines are IL-4, GM-CSF, IL-2, TNF-&agr;, and M-CSF in the secreted or membrane-bound form. In these embodiments, the cytokine-producing cells provide immunostimulation in trans to generate a specific immune response against the tumor antigen.
    Type: Application
    Filed: June 5, 2001
    Publication date: November 8, 2001
    Inventors: John C. Hiserodt, Martin R. Graf, Gale A. Granger
  • Cancer immunotherapy using autologous tumor cells combined with cells expressing a membrane cytokline
    Publication number: 20010036458
    Abstract: This invention comprises cellular vaccines and methods of using them in cancer immunotherapy, particularly in humans. The vaccines comprise a source of tumor-associated antigen, and a cytokine-secreting cell line. Tumor antigen may be provided in the form of primary tumor cells, tumor cell lines or tumor extracts prepared from the subject. In certain embodiments of the invention, the cytokine-secreting line is a separate tumor line that is allogeneic to the patient and genetically altered so as to produce a cytokine at an elevated level. Exemplary cytokines are IL-4, GM-CSF, IL-2, TNF-&agr;, and M-CSF in the secreted or membrane-bound form. In these embodiments, the cytokine-producing cells provide immunostimulation in trans to generate a specific immune response against the tumor antigen.
    Type: Application
    Filed: June 5, 2001
    Publication date: November 1, 2001
    Inventors: John C. Hiserodt, Martin R. Graf, Gale A. Granger
  • Cancer immunotherapy using autologous tumor cells combined with cells expressing a membrane cytokine
    Patent number: 6277368
    Abstract: This invention comprises cellular vaccines and methods of using them in cancer immunotherapy, particularly in humans. The vaccines comprise a source of tumor-associated antigen, and a cytokine-secreting cell line. Tumor antigen may be provided in the form of primary tumor cells, tumor cell lines or tumor extracts prepared from the subject. In certain embodiments of the invention, the cytokine-secreting line is a separate tumor line that is allogeneic to the patient and genetically altered so as to produce a cytokine at an elevated level. Exemplary cytokines are IL-4, GM-CSF, IL-2, TNF-&agr;, and M-CSF in the secreted or membrane-bound form. In these embodiments, the cytokine-producing cells provide immunostimulation in trans to generate a specific immune response against the tumor antigen.
    Type: Grant
    Filed: July 24, 1997
    Date of Patent: August 21, 2001
    Assignee: The Regents of the University of California
    Inventors: John C. Hiserodt, Martin R. Graf, Gale A. Granger