Abstract: A mass spectrometer is disclosed comprising a quadrupole rod set ion trap wherein a potential field is created at the exit of the ion trap which decreases with increasing radius in one radial direction. Ions within the ion trap are mass selectively excited in a radial direction. Ions which have been excited in the radial direction experience a potential field which no longer confines the ions axially within the ion trap but which instead acts to extract the ions and hence causes the ions to be ejected axially from the ion trap.

Abstract: A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell. Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell. The cell comprises a plurality of ring electrodes which form a spherical trapping volume. Ions experience negligible RF heating over the majority of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell having an enhanced sensitivity is thereby provided. Fragment ions created within the cell may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.

Abstract: A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell (1). Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell (1). The cell comprises a plurality of ring electrodes (1) which form a spherical trapping volume. Ions experience negligible RF heating over the majority, of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell (1) having an enhanced sensitivity is thereby provided. Fragment ions created within the cell (1) may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.

Abstract: A composition for topical application to the skin in order to promote the repair of photo-damaged or aged skin and/or to reduce or prevent damaging effects of ultra-violet light on skin and/or to lighten the skin comprising a hydrocalchone of general structure: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, represent H, --OH, --OR or --COR (where R is a C.sub.1-20 alkyl group);R.sub.4, R.sub.5, R.sub.6 and R.sub.7, which may be the same or different, represent H or --COR (where R is as herein before defined).Optional additional ingredients include sunscreens and other skin lightening skin lightening agents, particularly retinol or derivatives thereof.

Abstract: A preserved composition suitable for topical application to mammalian skin or hair for inducing, maintaining or increasing hair growth comprises:(i) a chemical activator of protein kinase C enzymes chosen from diacylglycerols having the structure (1): ##STR1## where X is the same or different, and is represented by the grouping: ##STR2## where x is 0 , or an integer of from 1 to 28, and y is 0 or an integer of from 1 to 5;the R groups being of either stereochemical configuration with respect to the carbon backbone of the glycerol molecule, and the double bonds beings of either cis or trans configuration; and(ii) a cosmetically acceptable vehicle for the chemical activator.

Abstract: In a disk storage device dedicated servo system, a reference track is written in the outer guardband of the servo surface and each of the data surfaces. Supplemental position error signal (PES) values are obtained from the difference of servo and data surface samples at a plurality of locations around the disk and stored for access during read/write operations. The supplemental PES values are combined with the dedicated surface PES values to yield a composite PES that more accurately follows the data track centerline of the disk surface being addressed. The supplemental PES values are also periodically updated. To provide a more accurate correction of the composite PES, two consecutive supplemental values are used and an interpolation is calculated to provide a continuously changing supplemental PES value for modification of each sector actuator drive pulse between the two current supplemental PES values.

Abstract: A transducer head skew arrangement used in a multiple disk drive data storage system is provided. The disk drive unit includes a plurality of magnetic disk surfaces mounted for simultaneous rotation about an axis. A first sequence of servo information tracks are arrayed on a dedicated servo disk surface. At least one servo reference track is written on each data disk surface for storing servo reference information. The servo reference track is written on a first data disk surface aligned with a predefined servo information track on the dedicated servo disk surface. Then servo reference tracks are sequentially written on each successive consecutive data disk surface progressively offset radially from the last written servo reference track. A plurality of data information tracks for storing data are disposed at predetermined positions relative to the servo reference track on each the data disk surface.

Abstract: A composition suitable for topical application to mammalian skin or hair for inducing, maintaining or increasing hair growth comprises:(i) a special protein tyrosine kinase inhibitor; and(ii) a cosmetically acceptable vehicle for the inhibitor.

Abstract: Disclosed is a method for performing a seek operation in a disk drive using current in the saturation mode to accelerate and decelerate the actuator arm. In a first embodiment, several measurements are made during the acceleration portion of the seek to estimate the deceleration available in saturation mode. In a second embodiment, the point at which the current is switched from acceleration current to deceleration current is adjusted based upon the position where the actuator arm comes within a desired amount of the velocity of a velocity profile assuming worst case conditions.

Abstract: A composition suitable for topical application to mammalian skin or hair comprises:(a) a growth factor chosen from:(i) transforming growth factor alpha (TGF-.alpha.),(ii) transforming growth factor beta (TGF-.beta.),(iii) insulin-like growth factor-1 (IGF-1),(iv) fragments thereof of one or more of said growth factors, and(v) mixtures thereof of said growth factors or fragments of said growth factors; and(b) a cosmetically acceptable vehicle for the growth factor or fragments thereof;the total amount of growth factor being sufficient to increase hair growth in the rate, when the composition is applies topically thereto over a period of no more than 3 months, by at least 10% more than that obtainable using a control composition from which the said growth factor has been omitted, in accordance with the Rat Hair Growth Test.

Abstract: A composition suitable for topical application to mammalian skin or hair, comprises an amount of the cell-free supernatant from a culture of dermal papilla fibroblasts which is sufficient to increase hair growth in the rat, when applied thereto, by at least 10% more than that obtainable using a control composition from which the said cell-free supernatant has been omitted.

Abstract: A cosmetically acceptable composition for topical application to human skin or hair in order to reduce greasiness comprises, at a concentration of from 0.0001M to 0.5M, a biotin antagonist which is capable of blocking the activity of the biotin dependent enzyme acetyl-SCoA-carboxylase implicated in sebum production; together with a carrier other than water as an aid to delivering the biotin antagonist to the sebaceous gland.