Patents by Inventor Martin Rettig

Martin Rettig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10329254
    Abstract: The invention relates to a novel process for the preparation of rac-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (I) in pharmaceutically acceptable polymorphic form, through the conversion of a 3-bromo-2-oxo-cyclohexanecarboxylic acid alkyl ester into 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid alkyl ester, which in turn is processed to yield the final product.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: June 25, 2019
    Assignee: AOP ORPHAN PHARMACEUTICALS AG
    Inventors: Enrica Diodato, Katia Marcucci, Russell Thomas, Paul Wiedenau, Martin Rettig, Huw Roberts
  • Publication number: 20160304455
    Abstract: The invention relates to a novel process for the preparation of rac-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (I) in pharmaceutically acceptable polymorphic form, through the conversion of a 3-bromo-2-oxo-cyclohexanecarboxylic acid alkyl ester into 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid alkyl ester, which in turn is processed to yield the final product.
    Type: Application
    Filed: April 20, 2016
    Publication date: October 20, 2016
    Inventors: Enrica DIODATO, Katia MARCUCCI, Russell THOMAS, Paul WIEDENAU, Martin RETTIG, Huw ROBERTS
  • Publication number: 20140303382
    Abstract: The invention relates to a novel process for the preparation of rac-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (I) in pharmaceutically acceptable polymorphic form, through the conversion of a 3-bromo-2-oxo-cyclohexanecarboxylic acid alkyl ester into 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid alkyl ester, which in turn is processed to yield the final product.
    Type: Application
    Filed: October 19, 2012
    Publication date: October 9, 2014
    Applicant: SIENA BIOTECH S.P.A.
    Inventors: Enrica Diodato, Katia Marcucci, Russell Thomas, Paul Wiedenau, Martin Rettig, Huw Roberts
  • Patent number: 7915421
    Abstract: Method for preparing (S)(+)phenyl acetic acid derivatives having the general formula (I): wherein R1 is a linear or branched alkyl group with 1-6 carbon atoms or substituted benzyl group, and R2 is methyl, ethyl or propyl group said method, characterised in that a compound of the general formula (II): wherein R1 is as given above, and R3 is a nucleofuge, or a suitable salt of a compound of the general formula (II) is reacted with a compound having the general formula (III): wherein R2 is as given above, and R4 is hydrogen or a nucleofuge that can be removed hydrolytically, and the protective group R4 that may be present, may be subsequently removed hydrolytically.
    Type: Grant
    Filed: May 13, 2004
    Date of Patent: March 29, 2011
    Assignee: Cilag Ltd.
    Inventors: Rainer Heck, Michael Justus, Roland Müller, Thomas Otten, Martin Rettig
  • Publication number: 20070123564
    Abstract: Method for preparing (S)(+)phenyl acetic acid derivatives having the general formula (I): wherein R1 is a linear or branched alkyl group with 1-6 carbon atoms or substituted benzyl group, and R2 is methyl, ethyl or propyl group said method, characterised in that a compound of the general formula (II): wherein R1 is as given above, and R3 is a nucleofuge, or a suitable salt of a compound of the general formula (II) is reacted with a compound having the general formula (III): wherein R2 is as given above, and R4 is hydrogen or a nucleofuge that can be removed hydrolytically, and the protective group R4 that may be present, may be subsequently removed hydrolytically.
    Type: Application
    Filed: May 13, 2004
    Publication date: May 31, 2007
    Inventors: Rainer Heck, Michael Justus, Roland Muller, Thomas Otten, Martin Rettig