Patents by Inventor Martin Rhiel

Martin Rhiel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220089648
    Abstract: This invention provides a robust fermentation process for the expression of a capsid protein of a bacteriophage which is forming a VLP by self-assembly, wherein the process is scalable to a commercial production scale and wherein the expression rate of the capsid protein is controlled to obtain improved yield of soluble capsid protein. This is achieved by combining the advantages of fed-batch culture and of lactose induced expression systems with specific process parameters providing improved repression of the promoter during the growth phase and high plasmid retention throughout the process.
    Type: Application
    Filed: April 13, 2021
    Publication date: March 24, 2022
    Inventors: Marcel EMMERLING, Frank HENNECKE, Holger PFRÜNDER, Martin RHIEL, Philipp STEINER
  • Publication number: 20200223891
    Abstract: This invention provides a robust fermentation process for the expression of a capsid protein of a bacteriophage which is forming a VLP by self-assembly, wherein the process is scalable to a commercial production scale and wherein the expression rate of the capsid protein is controlled to obtain improved yield of soluble capsid protein. This is achieved by combining the advantages of fed-batch culture and of lactose induced expression systems with specific process parameters providing improved repression of the promoter during the growth phase and high plasmid retention throughout the process.
    Type: Application
    Filed: October 16, 2019
    Publication date: July 16, 2020
    Inventors: Marcel EMMERLING, Frank HENNECKE, Holger PFRÜNDER, Martin RHIEL, Philipp STEINER
  • Publication number: 20170305972
    Abstract: This invention provides a robust fermentation process for the expression of a capsid protein of a bacteriophage which is forming a VLP by self-assembly, wherein the process is scalable to a commercial production scale and wherein the expression rate of the capsid protein is controlled to obtain improved yield of soluble capsid protein. This is achieved by combining the advantages of fed-batch culture and of lactose induced expression systems with specific process parameters providing improved repression of the promoter during the growth phase and high plasmid retention throughout the process.
    Type: Application
    Filed: November 17, 2016
    Publication date: October 26, 2017
    Inventors: Marcel EMMERLING, Frank HENNECKE, Holger PFRÜNDER, Martin RHIEL, Philipp STEINER
  • Patent number: 9518095
    Abstract: This invention provides a robust fermentation process for the expression of a capsid protein of a bacteriophage which is forming a VLP by self-assembly, wherein the process is scalable to a commercial production scale and wherein the expression rate of the capsid protein is controlled to obtain improved yield of soluble capsid protein. This is achieved by combining the advantages of fed-batch culture and of lactose induced expression systems with specific process parameters providing improved repression of the promoter during the growth phase and high plasmid retention throughout the process.
    Type: Grant
    Filed: April 7, 2014
    Date of Patent: December 13, 2016
    Assignee: KUROS BIOSCIENCES AG
    Inventors: Marcel Emmerling, Frank Hennecke, Holger Pfründer, Martin Rhiel, Philipp Steiner
  • Publication number: 20150104827
    Abstract: This invention provides a robust fermentation process for the expression of a capsid protein of a bacteriophage which is forming a VLP by self-assembly, wherein the process is scalable to a commercial production scale and wherein the expression rate of the capsid protein is controlled to obtain improved yield of soluble capsid protein. This is achieved by combining the advantages of fed-batch culture and of lactose induced expression systems with specific process parameters providing improved repression of the promoter during the growth phase and high plasmid retention throughout the process.
    Type: Application
    Filed: April 7, 2014
    Publication date: April 16, 2015
    Applicant: CYTOS BIOTECHNOLOGY AG
    Inventors: MARCEL EMMERLING, Frank Hennecke, Holger Pfründer, Martin Rhiel, Philipp Steiner
  • Publication number: 20120322103
    Abstract: This invention provides a robust fermentation process for the expression of a capsid protein of a bacteriophage which is forming a VLP by self-assembly, wherein the process is scalable to a commercial production scale and wherein the expression rate of the capsid protein is controlled to obtain improved yield of soluble capsid protein. This is achieved by combining the advantages of fed-batch culture and of lactose induced expression systems with specific process parameters providing improved repression of the promoter during the growth phase and high plasmid retention throughout the process.
    Type: Application
    Filed: December 22, 2011
    Publication date: December 20, 2012
    Applicant: Cytos Biotechnology AG
    Inventors: Marcel EMMERLING, Frank Hennecke, Holger Pfründer, Martin Rhiel, Philipp Steiner
  • Publication number: 20110008831
    Abstract: This invention provides a robust fermentation process for the expression of a capsid protein of a bacteriophage which is forming a VLP by self-assembly, wherein the process is scalable to a commercial production scale and wherein the expression rate of the capsid protein is controlled to obtain improved yield of soluble capsid protein. This is achieved by combining the advantages of fed-batch culture and of lactose induced expression systems with specific process parameters providing improved repression of the promoter during the growth phase and high plasmid retention throughout the process.
    Type: Application
    Filed: May 24, 2006
    Publication date: January 13, 2011
    Applicant: Cytos Biotechnology AG
    Inventors: Marcel Emmerling, Frank Hennecke, Holger Pfründer, Martin Rhiel, Philipp Steiner