Abstract: A plug-in contact device for preventing or extinguishing an arc when separating or closing a direct current connection includes: at least one plug-in connector each having a main contact, HA, and an auxiliary contact, HI, the HA including a first contact half, HA1, and a second contact half, HA2, which are releasably plugged together. The HA: electrically conductively connects the HA1 and the HA2 in a plugged-together state of the respective plug-in connector, galvanically separates the HA1 and the HA2 in a released state of the respective plug-in connector, electrically conductively connects the HA1 and the HA2 in a first intermediate state of the respective plug-in connector between the plugged-together state and the released state, and galvanically separates the HA1 and the HA2 in a second intermediate state of the respective plug-in connector between the first intermediate state and the released state.

Abstract: The present invention relates to a compound of a pharmaceutically acceptable salt thereof of formula (I) wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; x1 is a spacer or a chemical single bond covalently connecting (A) to the rest of the molecule; x2 is a spacer or a chemical single bond covalently connecting (C) to the rest of the molecule. The invention further relates to compositions comprising said compounds as well as a method for detecting neoplastic cells in a sample in vitro with the aid of the compounds or composition.

Abstract: An electric/electronic architecture for a motor vehicle includes an electronic computing device for communicating with at least one actuator of the motor vehicle. The electric/electronic architecture has an interface controller which is contacted by at least one sensor device of the motor vehicle and the electronic computing device, wherein the at least one actuator directly communicates with the electronic computing device, and the at least one sensor device directly communicates with the interface controller.

Abstract: A method for operating an internal combustion engine. The method includes: operating the internal combustion engine including a lambda regulation, which sets a fuel quantity to be supplied in accordance with a predefined setpoint lambda value, at preset times, carrying out a filter cleaning operation for a fuel tank ventilation, as a function of the presence of a release condition of the internal combustion engine, carrying out an adaptation of the lambda regulation by adapting at least one adaptation parameter as a function of operating variables of the internal combustion engine, at active filter cleaning operation and upon the presence of the release condition, operating variables which are required to carry out the adaptation of the lambda regulation being recorded, at deactivated filter cleaning operation and presence of the release condition, the adaptation of the lambda regulation being carried out as a function of the recorded operating variables.

Abstract: Herein is reported a method for determining the concentration of a therapeutic antibody in a tissue of an experimental animal to whom the therapeutic antibody had been administered, wherein the interference from residual blood in a tissue sample of the experimental animal, which is used for determining the concentration of the therapeutic antibody in said tissue, is reduced, wherein the concentration of the therapeutic antibody in the tissue of the experimental animal is calculated with the following formula: C tmAb , tissue = C t ? m ? A ? b , tissue , det . C t ? i ? s ? sue , sample - C r ? e ? f ? m ? A ? b , tissue , det . C t ? i ? s ? sue , sample C r ? e ? f ? m ? A ? b , plasma . det . * C t ? m ? A ? b , plasma , det . wherein CtmAb,tissue,det.=obtained by determining the concentration of the therapeutic antibody in the tissue sample of the experimental animal, CtmAb,plasma,det.

Abstract: This disclosure relates to a compressor having at least two compression stages. In particular, an exemplary compressor includes a first radial compression stage arranged along an axis, a second radial compression stage arranged along the axis, and a connector fluidly connecting an outlet of the first radial compression stage to an inlet of the second radial compression stage. The connector has a plurality of sections arranged about the axis. The compressor may be a refrigerant compressor used in a heating, ventilation, and air conditioning (HVAC) chiller system.

Abstract: The present invention relates to a compound or a pharmaceutically acceptable salt thereof having a chemical structure comprising: A compound or a pharmaceutically acceptable salt thereof of formula (I): (A)-x1-(B)-x2-(C), wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; x1 is a spacer covalently connecting (A) and (B); x2 is a spacer or a chemical single bond connecting (B) and (C); wherein (C) has the formula wherein R1 to R4, R9, a, b, Y and X1 to X4 have the meaning as indicated in the claims and description. The invention further relates to compositions comprising said compounds as well as a method for detecting neoplastic cells in a sample in vitro with the aid of the compounds or composition.

Abstract: A system includes a core drill and an automatic feed device. The core drill has a human machine interface (HMI) for controlling the core drill and the automatic feed device. A menu navigation of the HMI is automatically controllable in dependence on an operating state of the core drill or the automatic feed device. The menu navigation includes menu pages where the menu pages are displayable in dependence on the operating state of the core drill or the automatic feed device such that the menu navigation is controllable automatically depending on the operating state of the core drill or the automatic feed device.

Abstract: A device includes a first supply unit, which is connectable via a first switch element to a first consumer, a second supply unit, which is connectable via a second switch element and via one or more electric delimitation elements to the first consumer, and a third switch element, which is configured to bridge the one or more electric delimitation elements. A control unit is configured to cause the first switch element to close, and the second and third switch elements to open, in normal operation. The control unit is further configured to detect that a first supply voltage at the first supply unit has reached or fallen below a voltage threshold value, and in response causes first the second switch element to close, then the first switch element to open, and then the third switch element to close, such that the first consumer is coupled to the second supply unit.

Abstract: A method for operating a system that includes a main machine tool, an auxiliary device, and a transmission device with a first sending and receiving device assigned to the main machine tool and a second sending and receiving device assigned to the auxiliary device includes sending a first signal that represents a connection inquiry from the first sending and receiving device to the second sending and receiving device after an actuation of an input device of the main machine tool by a user. A second signal that represents a connection response from the second sending and receiving device is sent to the first sending and receiving device after an actuation of an actuating device of the auxiliary device by the user. The method further includes activating and/or testing an emergency cutout functionality of the actuating device by the actuation of the actuating device of the auxiliary device by the user.

Abstract: Herein is reported a method for determining the concentration of a therapeutic antibody in a tissue of an experimental animal to whom the therapeutic antibody had been administered, wherein the interference from residual blood in a tissue sample of the experimental animal, which is used for determining the concentration of the therapeutic antibody in said tissue, is reduced, wherein the concentration of the therapeutic antibody in the tissue of the experimental animal is calculated with the following formula: C tmAb , tissue = C tmAb , tissue , det . C tissue , sample - C refmAb , tissue , det . C tissue , sample C refmAb , plasma . det . * C tmAb , plasma , det . wherein CtmAb,tissue,det.=obtained by determining the concentration of the therapeutic antibody in the tissue sample of the experimental animal, CtmAb,plasma,det.

Abstract: A refrigerant compressor according to an exemplary aspect of the present disclosure includes, among other things, an impeller arranged in a main flow path and including a plurality of vanes. The impeller is configured to rotate about an axis. A channel is outside the main flow path. A first orifice fluidly couples the channel to the main flow path upstream of the vanes, and a second orifice fluidly couples the channel to the main flow path downstream of leading edges of the vanes.

Abstract: The present invention relates to bispecific anti-CCL2 antibodies binding to two different epitopes on human CCL2, pharmaceutical compositions thereof, their manufacture, and use as medicaments for the treatment of cancers, inflammatory, autoimmune and ophthalmologic diseases.

Abstract: The present invention relates to a compound or a pharmaceutically acceptable salt thereof having a chemical structure comprising: (A) at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; and (C) at least one dye moiety; wherein said compound has a molecular weight of not more than 5 kDa. Further, the invention refers to a method for producing such compound and to the in vivo and in vitro uses thereof.

Abstract: This disclosure relates to a compressor having at least two compression stages. In particular, an exemplary compressor includes a first radial compression stage arranged along an axis, a second radial compression stage arranged along the axis, and a connector fluidly connecting an outlet of the first radial compression stage to an inlet of the second radial compression stage. The connector has a plurality of sections arranged about the axis. The compressor may be a refrigerant compressor used in a heating, ventilation, and air conditioning (HVAC) chiller system.

Abstract: The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers and imaging agents for various disease states of prostate cancer.

Abstract: The present invention relates to a compound or a pharmaceutically acceptable salt thereof having a chemical structure comprising: A compound or a pharmaceutically acceptable salt thereof of formula (I): (A)-x1-(B)-x2-(C), wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; x1 is a spacer covalently connecting (A) and (B); x2 is a spacer or a chemical single bond connecting (B) and (C); wherein (C) has the formula wherein R1 to R4, R9, a, b, Y and X1 to X4 have the meaning as indicated in the claims and description.

Abstract: The present invention relates to a compound of a pharmaceutically acceptable salt thereof of formula (I) wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; x1 is a spacer or a chemical single bond covalently connecting (A) to the rest of the molecule; x2 is a spacer or a chemical single bond covalently connecting (C) to the rest of the molecule. The invention further relates to compositions comprising said compounds as well as a method for detecting neoplastic cells in a sample in vitro with the aid of the compounds or composition.

Abstract: The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers and imaging agents for various disease states of prostate cancer.

Abstract: A method for operating an internal combustion engine. The method includes: operating the internal combustion engine including a lambda regulation, which sets a fuel quantity to be supplied in accordance with a predefined setpoint lambda value, at preset times, carrying out a filter cleaning operation for a fuel tank ventilation, as a function of the presence of a release condition of the internal combustion engine, carrying out an adaptation of the lambda regulation by adapting at least one adaptation parameter as a function of operating variables of the internal combustion engine, at active filter cleaning operation and upon the presence of the release condition, operating variables which are required to carry out the adaptation of the lambda regulation being recorded, at deactivated filter cleaning operation and presence of the release condition, the adaptation of the lambda regulation being carried out as a function of the recorded operating variables.