Abstract: A rotary pressure filter suitable for use in treatment of one or more of medical products or foodstuffs, the rotary pressure filter. The rotary pressure filter comprises a filter drum that can be rotated about an axis of rotation. The rotary pressure filter comprises a plurality of filter cells arranged along an outer circumference of the filter drum, with a housing surrounding the filter drum. A process space is formed between the filter drum and the housing. The rotary pressure filter comprises at least one separating element dividing the process space into a plurality of treatment zones. At least one treatment zone is associated with a housing connector via which one or more of fluid or suspension can be introduced into the respective treatment zone.

Abstract: Herein is reported a method for determining the concentration of a therapeutic antibody in a tissue of an experimental animal to whom the therapeutic antibody had been administered, wherein the interference from residual blood in a tissue sample of the experimental animal, which is used for determining the concentration of the therapeutic antibody in said tissue, is reduced, wherein the concentration of the therapeutic antibody in the tissue of the experimental animal is calculated with the following formula: C tmAb , tissue = C t ? m ? A ? b , tissue , det . C t ? i ? s ? sue , sample - C r ? e ? f ? m ? A ? b , tissue , det . C t ? i ? s ? sue , sample C r ? e ? f ? m ? A ? b , plasma . det . * C t ? m ? A ? b , plasma , det . wherein CtmAb,tissue,det.=obtained by determining the concentration of the therapeutic antibody in the tissue sample of the experimental animal, CtmAb,plasma,det.

Abstract: This disclosure relates to a compressor having at least two compression stages. In particular, an exemplary compressor includes a first radial compression stage arranged along an axis, a second radial compression stage arranged along the axis, and a connector fluidly connecting an outlet of the first radial compression stage to an inlet of the second radial compression stage. The connector has a plurality of sections arranged about the axis. The compressor may be a refrigerant compressor used in a heating, ventilation, and air conditioning (HVAC) chiller system.

Abstract: In particular, the present invention relates to a PSMA binding ligand comprising an oligosaccharide building block which comprises a bond being cleavable by alpha-amylase. Typically, this PSMA binding ligand further comprises a PSMA binding motif Q and a chelator residue A, wherein the PSMA binding motif Q and the chelator residue A are preferably linked via at least one linker LAQ comprising the oligosaccharide building block, the PSMA binding ligand thus preferably having the structure (I) A-LAQ-Q or a pharmaceutically acceptable salt or solvate thereof.

Abstract: The present invention relates to a compound or a pharmaceutically acceptable salt thereof having a chemical structure comprising: A compound or a pharmaceutically acceptable salt thereof of formula (I): (A)-x1-(B)-x2-(C), wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; x1 is a spacer covalently connecting (A) and (B); x2 is a spacer or a chemical single bond connecting (B) and (C); wherein (C) has the formula wherein R1 to R4, R9, a, b, Y and X1 to X4 have the meaning as indicated in the claims and description. The invention further relates to compositions comprising said compounds as well as a method for detecting neoplastic cells in a sample in vitro with the aid of the compounds or composition.

Abstract: A system includes a core drill and an automatic feed device. The core drill has a human machine interface (HMI) for controlling the core drill and the automatic feed device. A menu navigation of the HMI is automatically controllable in dependence on an operating state of the core drill or the automatic feed device. The menu navigation includes menu pages where the menu pages are displayable in dependence on the operating state of the core drill or the automatic feed device such that the menu navigation is controllable automatically depending on the operating state of the core drill or the automatic feed device.

Abstract: The disclosure relates to a powder and a method for generating a component by a powder-bed-based additive manufacturing method, such as laser melting. The powder includes particles having a core and a shell. The particles have an alloy composition of the component. The concentration of higher-melting alloy elements is greater in the shell and the concentration of lower-melting alloy elements is greater in the core, wherein the surface of the particles is higher in comparison with particles with a constant alloy composition. This advantageously prevents the particles from caking together in the powder bed during the production of the component, and so the powder bed may also be subjected to high preheating temperatures of up to 1000° C.

Abstract: A device includes a first supply unit, which is connectable via a first switch element to a first consumer, a second supply unit, which is connectable via a second switch element and via one or more electric delimitation elements to the first consumer, and a third switch element, which is configured to bridge the one or more electric delimitation elements. A control unit is configured to cause the first switch element to close, and the second and third switch elements to open, in normal operation. The control unit is further configured to detect that a first supply voltage at the first supply unit has reached or fallen below a voltage threshold value, and in response causes first the second switch element to close, then the first switch element to open, and then the third switch element to close, such that the first consumer is coupled to the second supply unit.

Abstract: The present disclosure relates to a vehicle steering wheel, including: a steering wheel body with a hub region for attachment to a steering shaft, with a steering wheel rim and with at least one spoke for attaching the steering wheel rim to the hub region; an airbag initiation device; wherein an electromechanical triggering device has at least one force transducer, which is disposed between a projection and the steering wheel body and via which the impact absorber cover is supported on the steering wheel body, for measuring a force value that can be associated with an actuating force acting on the actuating surface of the impact absorber cover; wherein the electromechanical triggering device has at least one electronic evaluation unit connected in an electrically conductive manner to the force transducer to determine an actuating force value by a force value measured by the at least one force transducer.

Abstract: A vehicle steering wheel system is provided. The system includes a steering wheel body with a hub region for attachment to a steering shaft of a vehicle steering system, a steering wheel rim and at least one spoke for attaching the steering wheel rim to the hub region; an electromechanical triggering device for triggering an acoustic output by means of an acoustic warning device of the vehicle, wherein the triggering device has an impact absorber cover and at least one force transducer wherein a force value threshold is predefined for each force transducer, and a wake-up signal is transmitted via the data connection to the evaluation unit if the force value threshold is exceeded by at least one force value, so that the latter changes from the energy-saving mode into the operating mode in which an actuating force value is determined by force value measured by the at least one force transducer.

Abstract: A nickel-base alloy for high-temperature applications, preferably for gas turbines, and a process. A selective choice of alloy elements permits the provision of an alloy which can be used to produce components devoid of cracking.

Abstract: A production method for a component having integrated channels for internal fluid guidance, having a first region, which is connected to a second region, and wherein the channels extend both through the first region and through the second region. The geometry of the component is modified to the technological characteristics of both production methods. The first region is produced by a method for casting using lost models without undercuts, and proceeding from the first region, the second region is built up using an additive manufacturing method.

Abstract: The present invention relates to a rotary pressure filter, comprising a filter housing, and a filter drum, wherein a plurality of treatment zones comprises at least a suspension insertion zone and a discharge zone, wherein the rotary pressure filter is configured such that a pressure being present in the suspension insertion zone is higher than a pressure being present in the discharge zone, and that, each time a filter cell, coming from the discharge zone and containing gas having the discharge zone's pressure, enters the suspension insertion zone, the pressure of the suspension insertion zone drops, characterized in that the rotary pressure filter further comprises equipment that is configured to reduce and/or to slow the pressure drop of the pressure in the suspension insertion zone each time a filter cell coming from the discharge zone enters the suspension insertion zone.

Abstract: A method for operating a system that includes a main machine tool, an auxiliary device, and a transmission device with a first sending and receiving device assigned to the main machine tool and a second sending and receiving device assigned to the auxiliary device includes sending a first signal that represents a connection inquiry from the first sending and receiving device to the second sending and receiving device after an actuation of an input device of the main machine tool by a user. A second signal that represents a connection response from the second sending and receiving device is sent to the first sending and receiving device after an actuation of an actuating device of the auxiliary device by the user. The method further includes activating and/or testing an emergency cutout functionality of the actuating device by the actuation of the actuating device of the auxiliary device by the user.

Abstract: The present invention relates to a compound of formula (1) (I), wherein Y3 is O or S, wherein s, t, u and w are 0 or 1, wherein i is an integer of from 1 to 3, wherein j is an integer of from 3 to 5, and wherein Z1, Z2 and Z3 are selected from the group consisting of CO2H, —SO2H, —SO3H, —OSO3H, and -0P03H2, R1 is —CH3 or H, X is selected from the group consisting of alkylaryl, aryl, alkylheteroaryl and heteroaryl, Y1 and Y2 are selected from the group consisting of aryl, alkylaryl, cycloalkyl, heterocycloalkyl, heteroaryl and alkylheteroaryl, and wherein A is a chelator residue having a structure selected from the group consisting of (la), (lb) and (lc), wherein R2, R3, R4 and R5 are selected from the group consisting of H, —CH2—COOH and —CH2—C(=0)-NH2 or wherein R2 and R4 form a —(CH2)n— bridge with n being an integer of from 1 to 3, wherein n is preferably 2, and wherein r, v and q are 0 or 1, with the proviso that in case u and w are 0, q and v are 0, and (A) wherein u and w are 1, or (B) wherein u is 0 an

Abstract: Herein is reported a method for determining the concentration of a therapeutic antibody in a tissue of an experimental animal to whom the therapeutic antibody had been administered, wherein the interference from residual blood in a tissue sample of the experimental animal, which is used for determining the concentration of the therapeutic antibody in said tissue, is reduced, wherein the concentration of the therapeutic antibody in the tissue of the experimental animal is calculated with the following formula: C tmAb , tissue = C tmAb , tissue , det . C tissue , sample - C refmAb , tissue , det . C tissue , sample C refmAb , plasma . det . * C tmAb , plasma , det . wherein CtmAb,tissue,det.=obtained by determining the concentration of the therapeutic antibody in the tissue sample of the experimental animal, CtmAb,plasma,det.

Abstract: A refrigerant compressor according to an exemplary aspect of the present disclosure includes, among other things, an impeller arranged in a main flow path and including a plurality of vanes. The impeller is configured to rotate about an axis. A channel is outside the main flow path. A first orifice fluidly couples the channel to the main flow path upstream of the vanes, and a second orifice fluidly couples the channel to the main flow path downstream of leading edges of the vanes.

Abstract: The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of prostate cancer. Thus, the present invention concerns compounds that are represented by the general Formulae (Ia) or (Ib).

Abstract: The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of prostate cancer. Thus, the present invention concerns compounds that are represented by the general Formulae (Ia) or (Ib).

Abstract: The present invention relates to bispecific anti-CCL2 antibodies binding to two different epitopes on human CCL2, pharmaceutical compositions thereof, their manufacture, and use as medicaments for the treatment of cancers, inflammatory, autoimmune and ophthalmologic diseases.