Abstract: The present invention relates to a compound of formula (1) or a pharmaceutically acceptable salt or solvate thereof, wherein Y3 is O or S, wherein s, t, u and w are, independently of each other, 0 or 1, wherein i is an integer of from 1 to 3, wherein j is an integer of from 3 to 5, and wherein Z1, Z2 and Z3 are independently of each other, selected from the group consisting of CO2H, —SO2H, —SO3H, —OSO3H, and —OPO3H2, R1 is —CH3 or H, preferably H, X is selected from the group consisting of alkylaryl, aryl, alkylheteroaryl and heteroaryl, Y1 and Y2 are independently, of each other, selected from the group consisting of aryl, alkylaryl, cycloalkyl, heterocycloalkyl, heteroaryl and alkylheteroaryl, and wherein A is a chelator residue having a structure selected from the group consisting of (Ia), (Ib) and (Ic) wherein R2, R3, R4 and R5 are, independently of each other, selected from the group consisting of H, —CH2—COOH and —CH2—C(?O)—NH2 or wherein R2 and R4 form a —(CH2)n— bridge with n being an integer

Abstract: A rotary pressure filter, comprising a filter drum and a housing. A sensor is attached to the housing and emits light through a light-permeable section of the housing in the direction of a filter cake. The sensor receives light reflected from the filter cake through the light-permeable section of the housing. A processing unit compares properties of the emitted light with those of the received light and determines an absolute thickness of the filter cake and/or a change in the thickness of the filter cake over a pre-determined time. The invention further relates to a corresponding method.

Abstract: A nickel-base alloy for high-temperature applications, preferably for gas turbines, and a process. A selective choice of alloy elements permits the provision of an alloy which can be used to produce components devoid of cracking.

Abstract: The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of prostate cancer. Thus, the present invention concerns compounds that are represented by the general Formulae (Ia) or (Ib).

Abstract: The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of prostate cancer. Thus, the present invention concerns compounds that are represented by the general Formulae (Ia) or (Ib).

Abstract: The present disclosure relates to a vehicle steering wheel, including: a steering wheel body with a hub region for attachment to a steering shaft, with a steering wheel rim and with at least one spoke for attaching the steering wheel rim to the hub region; an airbag initiation device; wherein an electromechanical triggering device has at least one force transducer, which is disposed between a projection and the steering wheel body and via which the impact absorber cover is supported on the steering wheel body, for measuring a force value that can be associated with an actuating force acting on the actuating surface of the impact absorber cover; wherein the electromechanical triggering device has at least one electronic evaluation unit connected in an electrically conductive manner to the force transducer to determine an actuating force value by a force value measured by the at least one force transducer.

Abstract: The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of prostate cancer. Thus, the present invention concerns compounds that are represented by the general Formulae (Ia) or (Ib).

Abstract: The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of prostate cancer. Thus, the present invention concerns compounds that are represented by the general Formulae (Ia) or (Ib).

Abstract: A vehicle steering wheel system is provided. The system includes a steering wheel body with a hub region for attachment to a steering shaft of a vehicle steering system, a steering wheel rim and at least one spoke for attaching the steering wheel rim to the hub region; an electromechanical triggering device for triggering an acoustic output by means of an acoustic warning device of the vehicle, wherein the triggering device has an impact absorber cover and at least one force transducer wherein a force value threshold is predefined for each force transducer, and a wake-up signal is transmitted via the data connection to the evaluation unit if the force value threshold is exceeded by at least one force value, so that the latter changes from the energy-saving mode into the operating mode in which an actuating force value is determined by force value measured by the at least one force transducer.

Abstract: A computer-implemented method provides a time-dependent simulation model of a drive device. The drive device comprises an electric machine and a supply unit associated with the electric machine. A functional scope of the time-dependent simulation model is defined. A virtual image of the drive device is provided. The virtual image is modularly constructed, each module of the virtual image being configurable. In order to establish the time-dependent simulation model of the drive device with the defined functional scope, in accordance with the functional scope at least one module of the virtual image is selected and the at least one module is configured with respect to its level of detail.

Abstract: A production method for a component having integrated channels for internal fluid guidance, having a first region, which is connected to a second region, and wherein the channels extend both through the first region and through the second region. The geometry of the component is modified to the technological characteristics of both production methods. The first region is produced by a method for casting using lost models without undercuts, and proceeding from the first region, the second region is built up using an additive manufacturing method.

Abstract: A heater and/or cooler chamber includes a heat storage block or chunk. In the block a multitude of parallel, stacked slit pockets each dimensioned to accommodate a single plate shaped workpiece. Workpiece handling openings of the slit pockets are freed and respectively covered by a door arrangement. The slit pockets are tailored to snuggly surround the plate shaped workpieces therein so as to establish an efficient heat transfer between the heat storage block or chunk and the workpieces to be cooled or heated.

Abstract: A heater and/or cooler chamber includes a heat storage block or chunk. In the block a multitude of parallel, stacked slit pockets are each dimensioned to accommodate a single plate shaped workpiece. Workpiece handling openings of the slit pockets are freed and respectively covered by a door arrangement. The slit pockets are tailored to snugly surround the plate shaped workpieces therein so as to establish an efficient heat transfer between the heat storage block or chunk and the workpieces to be cooled or heated.

Abstract: A rotary pressure filter suitable for use in treatment of one or more of medical products or foodstuffs, the rotary pressure filter. The rotary pressure filter comprises a filter drum that can be rotated about an axis of rotation. The rotary pressure filter comprises a plurality of filter cells arranged along an outer circumference of the filter drum, with a housing surrounding the filter drum. A process space is formed between the filter drum and the housing. The rotary pressure filter comprises at least one separating element dividing the process space into a plurality of treatment zones. At least one treatment zone is associated with a housing connector via which one or more of fluid or suspension can be introduced into the respective treatment zone.

Abstract: In particular, the present invention relates to a PSMA binding ligand comprising an oligosaccharide building block which comprises a bond being cleavable by alpha-amylase. Typically, this PSMA binding ligand further comprises a PSMA binding motif Q and a chelator residue A, wherein the PSMA binding motif Q and the chelator residue A are preferably linked via at least one linker LAQ comprising the oligosaccharide building block, the PSMA binding ligand thus preferably having the structure (I) A-LAQ-Q or a pharmaceutically acceptable salt or solvate thereof.

Abstract: The disclosure relates to a powder and a method for generating a component by a powder-bed-based additive manufacturing method, such as laser melting. The powder includes particles having a core and a shell. The particles have an alloy composition of the component. The concentration of higher-melting alloy elements is greater in the shell and the concentration of lower-melting alloy elements is greater in the core, wherein the surface of the particles is higher in comparison with particles with a constant alloy composition. This advantageously prevents the particles from caking together in the powder bed during the production of the component, and so the powder bed may also be subjected to high preheating temperatures of up to 1000° C.

Abstract: A vehicle steering wheel system is provided. The system includes a steering wheel body with a hub region for attachment to a steering shaft of a vehicle steering system, a steering wheel rim and at least one spoke for attaching the steering wheel rim to the hub region; an electromechanical triggering device for triggering an acoustic output by means of an acoustic warning device of the vehicle, wherein the triggering device has an impact absorber cover and at least one force transducer wherein a force value threshold is predefined for each force transducer, and a wake-up signal is transmitted via the data connection to the evaluation unit if the force value threshold is exceeded by at least one force value, so that the latter changes from the energy-saving mode into the operating mode in which an actuating force value is determined by force value measured by the at least one force transducer.

Abstract: The present disclosure relates to a vehicle steering wheel, including: a steering wheel body with a hub region for attachment to a steering shaft, with a steering wheel rim and with at least one spoke for attaching the steering wheel rim to the hub region; an airbag initiation device; wherein an electromechanical triggering device has at least one force transducer, which is disposed between a projection and the steering wheel body and via which the impact absorber cover is supported on the steering wheel body, for measuring a force value that can be associated with an actuating force acting on the actuating surface of the impact absorber cover; wherein the electromechanical triggering device has at least one electronic evaluation unit connected in an electrically conductive manner to the force transducer to determine an actuating force value by a force value measured by the at least one force transducer.

Abstract: A nickel-base alloy for high-temperature applications, preferably for gas turbines, and a process. A selective choice of alloy elements permits the provision of an alloy which can be used to produce components devoid of cracking.

Abstract: A production method for a component having integrated channels for internal fluid guidance, having a first region, which is connected to a second region, and wherein the channels extend both through the first region and through the second region. The geometry of the component is modified to the technological characteristics of both production methods. The first region is produced by a method for casting using lost models without undercuts, and proceeding from the first region, the second region is built up using an additive manufacturing method.