Abstract: The present invention relates to binding molecules that comprise T cell receptor (TCR) variable domains and which can bind to a PRAME peptide-HLA complex. In particular, the present invention relates to binding molecules that bind to PYLGQMINL (SEQ ID NO: 1) in complex with HLA-A24. The invention also relates to the use of such molecules for the treatment of malignant diseases.

Abstract: An extreme ultraviolet (EUV) light source includes a providing device for providing a target material, a pulsed laser source for emitting a pulsed laser beam, and a beam guidance device for supplying the pulsed laser beam from the pulsed laser source into a radiation generation chamber and for focused irradiation of the target material with the pulsed laser beam. The target material is configured to emit EUV radiation on account of the irradiation. The beam guidance device includes a beam positioning device comprising four mirrors as two mirror pairs for positioning the pulsed laser beam. Each of the four mirrors is rotatable about exactly one axis of rotation. The axes of rotation of the two mirrors of a first mirror pair are aligned along a first spatial direction. The axes of rotation of the two mirrors of a second mirror pair are aligned along a second spatial direction.

Abstract: A vibratory cavity density meter (100-300) is provided. The vibratory cavity density meter (100-300) includes a pipe (110-310) extending from a first end (110a-310a) to a second end (110b-310b). The first end (110a-310a) includes an aperture (114-314) configured to receive a material from a container (10) and the second end (110b-310b) is self-enclosed so as to contain the material in the pipe (110-310). The vibratory cavity density meter (100-300) also includes at least one transducer (118, 218) coupled to the pipe (110-310), the at least one transducer (118, 218) configured to one of induce and sense a vibration in the pipe (110-310) to measure a property of the material.

Abstract: Method and apparatus (121) for providing temperature flow rate compensation for a Coriolis flow meter. The described compensation compensates both flow calibration factor and the nominal time delay, commonly called “zero” in the art. After a Coriolis flow meter is installed into a process, whether for calibration or for actual process use, it need only be zeroed once over its lifetime following its installation. This is a significant improvement over prior Coriolis flow meters that may need to be re-zeroed after minor changes in pressure, temperature, or installation.

Abstract: A method of manufacturing a Coriolis flowmeter for the measurement of a process material requiring an ultra high level of purity. This is achieved by forming the entire flow path of the Coriolis flow meter from a PFA plastic material that does not transfer ions from the Coriolis flowmeter to the process material flowing through the flowmeter.

Abstract: A flow meter pickoff assembly for nulling a flow meter zero offset is provided. The flow meter pickoff assembly includes a mounting device affixed to a first flow meter portion of a flow meter and a first pickoff sensor half adjustably affixed to the mounting device and configured to interact with a second pickoff sensor half affixed to a second flow meter portion. At least one relative angle of the first pickoff sensor half in relation to the second pickoff sensor half can be adjusted by adjusting the first pickoff sensor half to the mounting device according to at least one adjustment axis. The flow meter pickoff assembly further includes an adjustment means for enabling the first pickoff sensor half to adjust with respect to the mounting device along the at least one adjustment axis in order to adjust the at least one relative angle.

Abstract: A Coriolis flowmeter for the measurement of a process material requiring an ultra high level of purity. This is achieved by forming the entire Coriolis flowmeter of a PFA plastic material that does not transfer ions from the Coriolis flowmeter to the process material flowing through the flowmeter.