Abstract: The present invention relates to a progressive addition lens and to a method for manufacturing the same. A lens comprises a rear surface intended to face an eye of the user and a front surface opposite to the rear surface. The present invention is particularly related to defining the rear surface of the lens. The present invention shows that it is possible to enhance image quality by using rotational symmetry in combination with a predefined progression curve to thereby avoid astigmatic imaging and also substantially reducing the effects of spherical aberration, coma, curvature of field and distortion.

Abstract: A pressure vessel for storing gaseous fuel has a vessel wall which surrounds an interior, wherein one or more ribs are formed on the vessel wall. A pressure vessel system, particularly for a motor vehicle, includes at least two such pressure vessels. A method is disclosed to form the ribs on the vessel wall of the pressure vessel.

Abstract: The present invention relates to a method of producing low viscous and highly concentrated biopharmaceutical drug products comprising a biomolecule of interest, the method comprising: (a) a first phase of preparing a drug substance of the biomolecule of interest, said first phase comprising at least one processing step selected from (a1) harvesting, (a2) purification, (a3) re-buffering, and (a4) enrichment, wherein said at least one processing step in this first phase is carried out in the presence of a composition comprising at least three amino acids, wherein the combination of said at least three amino acids provides at least one positively charged functional group, at least one anti-oxidative functional group, at least one osmolytic function, and at least one buffering function, and (b) a second phase of further processing the drug substance prepared in (a) to obtain a low viscous and highly concentrated biopharmaceutical drug product, said second phase comprising at least one processing step selected fro

Abstract: A method may include generating a first user interface for providing, to a client, a first selection of inputs for attributes of a rule scenario for defining a rule. The rule may be applied to modify a data processing functionality of the application. Parameters of the rule may be determined based on the rule scenario and a first input from the first selection of inputs being selected via the first user interface. The parameters of the rule may correspond to data objects affected by the application of the rule. A second user interface for providing, to the client, a second selection of inputs for defining a condition of the rule may be generated. The condition of the rule may evaluate the parameters of the rule. The rule may be generated based on a second input from the second selection of inputs being selected via the second user interface.

Abstract: The present invention relates to a method of producing low viscous and highly concentrated biopharmaceutical drug products comprising a biomolecule of interest, the method comprising: (a) a first phase of preparing a drug substance of the biomolecule of interest, said first phase comprising at least one processing step selected from (a1) harvesting, (a2) purification, (a3) re-buffering, and (a4) enrichment, wherein said at least one processing step in this first phase is carried out in the presence of a composition comprising at least three amino acids, wherein the combination of said at least three amino acids provides at least one positively charged functional group, at least one anti-oxidative functional group, at least one osmolytic function, and at least one buffering function, and (b) a second phase of further processing the drug substance prepared in (a) to obtain a low viscous and highly concentrated biopharmaceutical drug product, said second phase comprising at least one processing step selected fro

Abstract: The present invention relates to a progressive addition lens and to a method for manufacturing the same. A lens comprises a rear surface intended to face an eye of the user and a front surface opposite to the rear surface. The present invention is particularly related to defining the rear surface of the lens. The present invention shows that it is possible to enhance image quality by using rotational symmetry in combination with a predefined progression curve to thereby avoid astigmatic imaging and also substantially reducing the effects of spherical aberration, coma, curvature of field and distortion.

Abstract: The present invention relates to a method for preparing viral vector-based compositions wherein the viral vector-based particles present in the composition have a particle size distribution with a polydispersity index (PDI) of less than 0.5, the method comprising the steps: (a) providing replication-deficient viral vectors; (b) providing a solution comprising at least one sugar and at least three different excipients selected from hydrophilic and amphiphilic excipients, wherein the excipients are characterized by polar, aliphatic, aromatic, negatively charged, and/or positively charged functional groups, and wherein the solution is further characterized by an excipient-sugar ratio of at least 1:2 (w/w); and (c) mixing the replication deficient viral vectors of step (a) with the solution of step (b).

Abstract: The present invention relates to a method for preparing viral vector-based compositions wherein the viral vector-based particles present in the composition have a particle size distribution with a polydispersity index (PDI) of less than 0.5, the method comprising the steps: (a) providing replication-deficient viral vectors; (b) providing a solution comprising at least one sugar and at least three different excipients selected from hydrophilic and amphiphilic excipients, wherein the excipients are characterized by polar, aliphatic, aromatic, negatively charged, and/or positively charged functional groups, and wherein the solution is further characterized by an excipient-sugar ratio of at least 1:2 (w/w); and (c) mixing the replication deficient viral vectors of step (a) with the solution of step (b).

Abstract: The present invention relates to a method for stabilising viruses or bacteria, the method comprising embedding the viruses or bacteria in an aqueous solution, wherein the solution comprises: (i) at least three different amino acids; or (ii) at least one dipeptide or tripeptide and wherein the solution is free or substantially free of sugar(s), silanes and protein(s).

Abstract: Proposed is a decorative element containing (a) a transparent gemstone with a faceted surface comprising convex curved regions, (b) a transparent electrically conductive layer applied to said faceted surface comprising convex curved regions, (c) a wavelength-selective layer applied (c1) to the planar side opposite to the faceted curved surface, or (c2) to the photovoltaic cell (d); (d) a photovoltaic cell; and (e) a touch-sensitive electronic circuitry.

Abstract: Proposed is a decorative element containing (a) a gemstone, (b) an electrically conductive layer on at least a partial area of the gemstone; and (c) an electronic sensor.

Abstract: Methods and apparatus are disclosed for efficient combinatorial testing of multi-level datatypes and data objects. A multi-level datatype associated with a software library has a plurality of linked levels with corresponding metadata attributes. A sparse set of metadata combinations is generated, providing full coverage of identified tuples of the metadata. Multi-level test datatypes are defined, with metadata attributes following the generated metadata combinations, and used to execute a test suite and validate the software library. A user interface of the software library can be tested and validated directly using the defined test datatypes. Alternatively, functions of the software library can be tested with test objects that are instances of the test datatypes. In variations, the software library can be tested for combinations of data values, or a mix of data and metadata. The software library can be a rules framework providing configuration and implementation of if-then rules for client applications.

Abstract: Methods and apparatus are disclosed for efficient combinatorial testing of multi-level datatypes and data objects. A multi-level datatype associated with a software library has a plurality of linked levels with corresponding metadata attributes. A sparse set of metadata combinations is generated, providing full coverage of identified tuples of the metadata. Multi-level test datatypes are defined, with metadata attributes following the generated metadata combinations, and used to execute a test suite and validate the software library. A user interface of the software library can be tested and validated directly using the defined test datatypes. Alternatively, functions of the software library can be tested with test objects that are instances of the test datatypes. In variations, the software library can be tested for combinations of data values, or a mix of data and metadata. The software library can be a rules framework providing configuration and implementation of if-then rules for client applications.

Abstract: The present invention relates to a method for producing stabilised vaccines, the method comprising: (a) mixing antigens with a solution comprising: (i) chitosan; (ii) at least three different amino acids and/or at least one dipeptide or tripeptide; and (iii) a sugar; and (b) drying the mixture obtained in (a).

Abstract: A method may include generating a first user interface for providing, to a client, a first selection of inputs for attributes of a rule scenario for defining a rule. The rule may be applied to modify a data processing functionality of the application. Parameters of the rule may be determined based on the rule scenario and a first input from the first selection of inputs being selected via the first user interface. The parameters of the rule may correspond to data objects affected by the application of the rule. A second user interface for providing, to the client, a second selection of inputs for defining a condition of the rule may be generated. The condition of the rule may evaluate the parameters of the rule. The rule may be generated based on a second input from the second selection of inputs being selected via the second user interface.

Abstract: The present invention relates to a method for preventing the unfolding of a (poly)peptide during drying and/or inducing the (re-)folding of a (poly)peptide after drying, comprising the step of embedding the (poly)peptide in an aqueous solution, wherein the solution comprises (i) at least three different amino acids; or (ii) at least one dipeptide or tripeptide; and wherein the solution is free or substantially free of (a) sugar; and (b-i) protein; and/or (b-ii) denaturing compounds; and (c) silanes.

Abstract: The present invention relates to a method for filtering blood to produce plasma or serum and to a blood filter for the production of plasma or serum from a blood sample. The invention further relates to a kit comprising a blood filter for the production of plasma or serum from a blood sample and a syringe.

Abstract: The present invention relates to a method for preparing viral vector-based compositions wherein the viral vector-based particles present in the composition have a particle size distribution with a polydispersity index (PDI) of less than 0.5, the method comprising the steps: (a) providing replication-deficient viral vectors; (b) providing a solution comprising at least one sugar and at least three different excipients selected from hydrophilic and amphiphilic excipients, wherein the excipients are characterized by polar, aliphatic, aromatic, negatively charged, and/or positively charged functional groups, and wherein the solution is further characterized by an excipient-sugar ratio of at least 1:2 (w/w); and (c) mixing the replication deficient viral vectors of step (a) with the solution of step (b).

Abstract: The present invention relates to a method of producing a liquid biopharmaceutical drug product, comprising a biomolecule of interest, the method comprising: (a) a first phase of preparing a drug substance of the biomolecule of interest, said first phase comprising at least one processing step selected from (a1) harvesting, (a2) purification, (a3) re-buffering, and (a4) enrichment, wherein said at least one processing step in this first phase is carried out in the presence of a composition comprising at least three amino acids, wherein the combination of said at least three amino acids provides at least one positively charged functional group, at least one anti-oxidative functional group, at least one osmolytic function, and at least one buffering function, and (b) a second phase of further processing the drug substance prepared in (a) to obtain a liquid biopharmaceutical drug product, said second phase comprising at least one processing step selected from (b1) re-buffering, (b2) freezing, (b3) thawing, and (b

Abstract: The present invention relates to a method of producing low viscous and highly concentrated biopharmaceutical drug products comprising a biomolecule of interest, the method comprising: (a) a first phase of preparing a drug substance of the biomolecule of interest, said first phase comprising at least one processing step selected from (a1) harvesting, (a2) purification, (a3) re-buffering, and (a4) enrichment, wherein said at least one processing step in this first phase is carried out in the presence of a composition comprising at least three amino acids, wherein the combination of said at least three amino acids provides at least one positively charged functional group, at least one anti-oxidative functional group, at least one osmolytic function, and at least one buffering function, and (b) a second phase of further processing the drug substance prepared in (a) to obtain a low viscous and highly concentrated biopharmaceutical drug product, said second phase comprising at least one processing step selected fro