Abstract: The invention provides B7-H3 targeting fusion proteins and methods of use thereof. The targeting fusion proteins include B7-H3 targeting tri-specific killer engager molecules comprising a B7-H3 targeting binding protein, a CD16 targeting binding protein, and an interleukin-15 protein. The methods of use thereof include methods of treating cancer, methods of inducing natural killer (NK) cell activity against a cancer cell, methods of inhibiting tumor growth, methods of increasing survival of a subject having cancer, and methods of inducing NK-mediated antibody-dependent cellular cytotoxicity against a cancer cell in a subject.

Abstract: A head coil arrangement is for a magnetic resonance tomograph. In an embodiment, the head coil arrangement includes a send coil unit and a receive coil unit. The send coil unit, in the position in which the head coil arrangement is normally used on a patient, is automatically positionable in the longitudinal direction of the patient relative to the head coil arrangement. A further embodiment relates to a magnetic resonance facility comprising the head coil arrangement and a guide element, embodied to transmit a force to a dog. The send coil unit is positionable via the force on the dog.

Abstract: The invention provides PD-L1 targeting fusion proteins and methods of use thereof. The targeting fusion proteins include tri-specific killer engager molecules including a camelid or a human CD16 natural killer (NK) cell engager domain, a wild type or a mutant IL-15 cytokine NK activating domain and a light chain and a heavy chain of a PD-L1 targeting peptide. The methods of use include methods of treating cancer.

Abstract: An immunotherapy compound includes an NK cell engaging domain, an NK activating domain and a targeting domain. The targeting domain selectively binds to HER2, HERS, or the HER2/HER3 heterodimer complex and is operably linked to the NK activating domain and the NK cell engaging domain. The compound may be administered to a subject to induce NK-mediated killing of a cancer cell, to stimulate expansion of NK cells in the subject, and/or for treating cancer.

Abstract: A head coil arrangement is for a magnetic resonance tomograph. In an embodiment, the head coil arrangement includes a send coil unit and a receive coil unit. The send coil unit, in the position in which the head coil arrangement is normally used on a patient, is automatically positionable in the longitudinal direction of the patient relative to the head coil arrangement. A further embodiment relates to a magnetic resonance facility comprising the head coil arrangement and a guide element, embodied to transmit a force to a dog. The send coil unit is positionable via the force on the dog.

Abstract: A method for operating a traffic monitoring device. A sensor signal is provided by a sensor device of the traffic monitoring device is first of all read in. An item of information is then generated using the sensor signal. Finally, the information is output to an interface to at least one vehicle.

Abstract: The disclosure relates to a method for authenticating a user to a machine: generating a challenge by the machine, generating a first pattern, in which the challenge is coded, by the machine, displaying the first pattern on a display device of the machine, optically recording the first pattern by a user device, decoding the first pattern to receive the challenge by the user device, generating a response to the challenge by the user device, generating a second pattern, in which the response is coded, by the user device, displaying the second pattern on a display device of the user device, optically recording the second pattern by the machine, decoding the second pattern to receive the response by the machine, checking the correctness of the response by the machine, and, on the condition that the response is correct, fulfilling a function by the machine.

Abstract: A method for operating a traffic monitoring device. A sensor signal is provided by a sensor device of the traffic monitoring device is first of all read in. An item of information is then generated using the sensor signal. Finally, the information is output to an interface to at least one vehicle.

Abstract: A pharmaceutical composition for shifting a Th2 immune response to a Th1 response by natural killer T cells (NKT cells) including a therapeutically effective amount of a glycolipid of one or more of Formulas II-V or a pharmaceutically acceptable salt thereof, and a pharmaceutical carrier is provided.

Abstract: A device is provide for operating a machine tool. The machine tool includes a rotation unit designed to rotate a workpiece about an axis of rotation with an adjustable rotational speed progression, and an ultra-short pulse laser for generating laser pulses, the laser being arranged such that material of the workpiece is removed by means of the laser pulses. The device is configured to adjust the rotational speed progression based on geometry data of a specified geometry and/or a specified surface quality characteristic value representative of a corresponding surface quality.

Abstract: A system and method of synchronizing recipes and bills of materials (BOM). An approved recipe is parameterized in a planning interface. A BOM is synchronized with the parameterized recipe. The BOM is then displayed in a graphical user interface to allow a user to modify by a resolve conflict present during synchronization.

Abstract: A process of preparing cyclic ethers is described. The process involves the reaction of at least one organic compound such as a dioi or a polyol which it has at least one pair of hydroxyl groups separated by 4 or 5 carbon atoms, and which is capable of being converted into an ether linkage, with an organic carbonate in the presence of a base. The base is an alkoxy, a carbonate or a hydroxide base or is a mixture of such bases. At least one of the hydroxyl groups of the organic compound is not a tertiary hydroxyl group.

Abstract: The invention relates, in particular to a tetrahydropyran(on) compound which is substituted in position beta with respect to a cycle oxygen of formula (I), wherein a substituent R is a linear alkyl radical in C2:C10 including, (CH3)2CH— or C6H5—(CH2)m—, with m=0 or 1, or formula (II), wherein A is —CH2— or —CO—, in the form of an odorant and to a method for the synthesis thereof by reducing oxo-ester. The use of the inventive compound in composition such as perfumery compositions in the ordinary sense of the term i.e. topic, in particular cosmetic compositions and care products.

Abstract: An installation device for a gradient coil module in a magnetic resonance tomography apparatus has a loading cart that moves the gradient coil module away from and to the magnetic resonance tomography apparatus. A bearing girder having a track is fastened to the loading cart. Track rollers can be installed on the gradient coil module such that the gradient coil module can be moved relative to the loading cart by means of the track rollers resting on the track.

Abstract: A system and method of synchronizing recipes and bills of materials (BOM). An approved recipe is parameterized in a planning interface. A BOM is synchronized with the parameterized recipe. The BOM is then displayed in a graphical user interface to allow a user to modify by a resolve conflict present during synchronization.

Abstract: A process of preparing cyclic ethers is described. The process involves the reaction of at least one organic compound such as a dioi or a polyol which it has at least one pair of hydroxyl groups separated by 4 or 5 carbon atoms, and which is capable of being converted into an ether linkage, with an organic carbonate in the presence of a base. The base is an alkoxy, a carbonate or a hydroxide base or is a mixture of such bases. At least one of the hydroxyl groups of the organic compound is not a tertiary hydroxyl group.

Abstract: A compound of formula (I); its structure represented with dotted lines being either cis- or trans-double bonds wherein: A) R1 represents a hydrogen atom and R2 represents an OH, OCH3 or OC2H5 group while either a) R4, R5, and R7 each represent hydrogen atoms with R3, R6, and R8 each representing methyl radicals; b) R4, R6, and R7 each represent hydrogen atoms with R3, R5, and R8 each representing methyl radicals; or c) R3, R6 and R7 each represent hydrogen atoms with R4, R5, and R8, each representing methyl radicals; or B) R7 represents a hydrogen atom; R1, R4, and R6 each represent hydrogen atoms with R2, R3, and R5 each representing a methyl radical while R8 represents OH, OCH3 or OC2H5 groups when dotted lines are present; when dotted lines are absent, R8 represents either OCH3 or OC2H5 groups. At least one compound is applied as an odorant agent.

Abstract: Disclosed is a method for pictorially representing and determining tissue densities of a body region, especially in the mouth/jaw/face region (1), of a patient. According to said method, a set of three-dimensional image data representing the body region as well as calibration data that is provided as three-dimensional image data and represents a calibration phantom (5, 8, 15) having a previously known density are photographed by generating an image while the tissue densities are derived from a comparison of the calibration data with the image data. The image data and the calibration data are photographed in the framework of the same shot and in an upright position of the patient, particularly during sitting or standing. The calibration phantom (5, 8, 15) is held in the immediate vicinity of the body region (1) that is to be photographed during the shot by means of a fixture (4, 10, 14) which is fixed independently of the patient's body and in a defined relation to the imaging device.

Abstract: An installation device for a gradient coil module in a magnetic resonance tomography apparatus has a loading cart that moves the gradient coil module away from and to the magnetic resonance tomography apparatus. A bearing girder having a track is fastened to the loading cart. Track rollers can be installed on the gradient coil module such that the gradient coil module can be moved relative to the loading cart by means of the track rollers resting on the track.

Abstract: A compound of general formula (I) with or without the double bond illustrated by the dotted line. In formula (I), X is a CHO, CH2OH, CH2OC(O)R or CH(OR)2 group, and R represents a linear or branched C1-C5 alkyl or alkenyl chain. The synthesis method for the compound, and especially the 6,8-dimethyl-non-7-enal (1) prepared by the hydroformylation of the 5,7-dimethyl-octa-1,6-diene is also disclosed, as well as compositions containing the compounds of formula (I). Due to the odorant properties thereof, the compounds are highly useful in perfumery, especially for cosmetic products and household products.