Patents by Inventor Martin Schuler

Martin Schuler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200253194
    Abstract: The present invention relates to a perfusion loop assembly for an ex vivo liver perfusion including: a pump for providing a fluid flow of a perfusion fluid through a first branch line and a second branch line; the first branch line being configured to provide a first portion of the perfusion fluid to the hepatic artery of the liver; the first branch line being coupled with a first gas exchanger, the second branch line being configured to provide a second portion of the perfusion fluid to the portal vein of the liver; the second branch line further including a first valve for controlling the flow of the perfusion fluid into the portal vein of the liver, a liver chamber assembly configured to hold the liver ex vivo, a liver outlet line attached to the vena cava of the ex vivo liver, at least one reservoir connected to the liver outlet and upstream from the pump.
    Type: Application
    Filed: July 21, 2017
    Publication date: August 13, 2020
    Inventors: Pierre-Alain Clavien, Philipp Rudolf von Rohr, Philipp Dutkowski, Rolf Graf, Martin Schuler, Dilmurodjon Eshmuminov, Brian Burg
  • Patent number: 9115392
    Abstract: A method of detecting at least one gene modification such as a mutation in a gene includes carrying out an asymmetric polymerase chain reaction (PCR) with a combined use of at least one detectable mutation-specific hybridization probe (sensor probe) and at least one wild-type specific blocking agent which inhibits a binding of the at least one detectable mutation-specific hybridization probe (sensor probe) to a wild-type gene so as to provide at least one of a selective intensification and an amplification of a detection of a gene segment of a mutation gene having a gene modification.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: August 25, 2015
    Assignee: UNIVERSITAET DUISBURG-ESSEN
    Inventors: Martin Schuler, Frank Breitenbuecher, Sandra Hoffarth, Sarah-Luise Stergar
  • Patent number: 8967293
    Abstract: A method and a device to thermally fragment rock for excavation of vertical and directional boreholes in rock formations, preferentially hard rock, using highly exothermic reactions. Exothermic reactions are initiated directly in the pressurized, aqueous environment of a water-based drilling fluid preferably above the critical pressure of water (221 bar). After reaction onset temperatures within the reaction zone exceed the critical temperature for water (374° C.) providing supercritical conditions, which favor the stabilization of the reaction, e.g. a supercritical hydrothermal flame. Since reactions can be run directly in a water-based drilling fluid, the method proposed here allows high density drilling action as in conventional rotary drilling. A part from the hot reaction zone of the proposed reaction can be brought directly to the rock surface in case of hard polycrystalline rock, where high temperatures are required.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: March 3, 2015
    Assignee: ETH Zurich
    Inventors: Philipp Rudolf Von Rohr, Tobias Rothenfluh, Martin Schuler
  • Publication number: 20130302798
    Abstract: A method for detecting at least one gene modification, such as a mutation in a gene, such as a gene that codes for a protein associated with at least one of a tumor and a cancer. The method includes providing a detectable hybridization probe (sensor probe) which interacts with/binds to a gene not having a gene modification (wild type gene) and with a gene having a gene modification (mutation gene). The detectable hybridization probe (sensor probe) has at least one of a higher specificity, a higher binding affinity and a higher selectivity for the gene not having a gene modification (wild type gene) compared to the gene having a gene modification (mutation gene). At least one gene modification is detected with the detectable hybridization probe (sensor probe).
    Type: Application
    Filed: July 4, 2011
    Publication date: November 14, 2013
    Applicant: UNIVERSITAET DUISBURG-ESSEN
    Inventors: Martin Schuler, Frank Breitenbuecher, Sandra Hoffarth, Sarah-Luise Boeck
  • Publication number: 20120244538
    Abstract: A method of detecting at least one gene modification such as a mutation in a gene includes carrying out an asymmetric polymerase chain reaction (PCR) with a combined use of at least one detectable mutation-specific hybridization probe (sensor probe) and at least one wild-type specific blocking agent which inhibits a binding of the at least one detectable mutation-specific hybridization probe (sensor probe) to a wild-type gene so as to provide at least one of a selective intensification and an amplification of a detection of a gene segment of a mutation gene having a gene modification.
    Type: Application
    Filed: September 9, 2010
    Publication date: September 27, 2012
    Inventors: Martin Schuler, Frank Breitenbuecher, Sandra Hoffarth, Sarah-Luise Stergar
  • Publication number: 20110303460
    Abstract: A method and a device to thermally fragment rock for excavation of vertical and directional boreholes in rock formations, preferentially hard rock, using highly exothermic reactions. Exothermic reactions are initiated directly in the pressurized, aqueous environment of a water-based drilling fluid preferably above the critical pressure of water (221 bar). After reaction onset temperatures within the reaction zone exceed the critical temperature for water (374° C.) providing supercritical conditions, which favor the stabilization of the reaction, e.g. a supercritical hydrothermal flame. Since reactions can be run directly in a water-based drilling fluid, the method proposed here allows high density drilling action as in conventional rotary drilling. A part from the hot reaction zone of the proposed reaction can be brought directly to the rock surface in case of hard polycrystalline rock, where high temperatures are required.
    Type: Application
    Filed: December 22, 2009
    Publication date: December 15, 2011
    Applicant: ETH ZURICH
    Inventors: Philipp Rudolf Von Rohr, Tobias Rothenfluh, Martin Schuler
  • Publication number: 20080214521
    Abstract: The present invention relates to a method of treating non-small cell lung cancer with FLT-3 kinase inhibitor such as PKC412. The invention also relates to a pharmaceutical combination of a FLT-3 kinase inhibitor and an activator of permeabilization of the mitochondrial outer membrane, such as an activator of BAK. It also relates to the use of a pharmaceutical combination of an activator of permeabilization of the mitochondrial outer membrane and a FLT-3 kinase inhibitor for the treatment of non-small cell lung cancer and the use of such a pharmaceutical composition for the manufacture of a medicament for the treatment of same.
    Type: Application
    Filed: August 7, 2006
    Publication date: September 4, 2008
    Inventor: Martin Schuler
  • Publication number: 20070190107
    Abstract: The present invention relates to an implant (1) with at least partially a roughened surface (2), which is at least partially covered by an organic or polymeric intermediate layer (3) and attached thereto a top layer (4). The top layer (4) provides for a controlled release of at least one bioactive agent. A kit for preparing such an implant is also described.
    Type: Application
    Filed: January 11, 2007
    Publication date: August 16, 2007
    Applicant: Straumann Holding AG
    Inventors: Samuele Tosatti, Diana Trentin, Martin Schuler, Michael De Wild
  • Patent number: 4271837
    Abstract: The present invention relates to an electrosurgical cutting device for the cutting and/or coagulation of tissue with RF current. A cutting electrode and a patient plate are connectable to the terminals of a RF generator. A control system, using a condition change arising at the cutting area during cutting as a controlled value, serves to control the RF current produced by the RF generator as a manipulated variable. The invention is characterized in that, for control of the RF-voltage of the RF generator, the control system responds to d-c voltage that arises at the cutting area during cutting with the RF current.
    Type: Grant
    Filed: January 16, 1979
    Date of Patent: June 9, 1981
    Assignee: Aesculap-Werke Aktiengesellschaft vormals Jetter & Scheerer
    Inventor: Martin Schuler