Abstract: Provided herein are opioid receptor modulators and pharmaceutical compositions comprising said compounds.

Abstract: The present invention relates to an injector for injecting gas, in particular hydrogen, preferably for directly injecting hydrogen, comprising an injector housing for holding injector components, a valve needle movably arranged along its longitudinal axis in the injector housing and configured to selectively close or release an injection opening for the flow of hydrogen therethrough, and a valve, preferably a solenoid valve, which is adapted to transfer the valve needle into a closing or releasing state by a movement along its longitudinal axis. The injector is characterized in that the valve needle is a hollow needle adapted to pass a gas, in particular hydrogen, flowing through the injection port through the interior of the hollow needle.

Abstract: A MEMS pump includes a basis structure, a membrane structure opposing the basis structure and being deflectable parallel to a surface normal of the basis structure and includes a pump chamber between the basis structure and the membrane structure wherein a volume of the pump chamber is based on a position of the membrane structure with respect to the basis structure. The MEMS pump includes a passage for letting a fluid pass into the pump chamber or exit the pump chamber, wherein the passage is arranged in-plane with respect to the pump chamber. The MEMS pump includes a valve structure coupled to the passage for connecting, in a first state, the passage to a first outer volume and for connecting, in a second state, the passage to a second outer volume.

Abstract: A thermoresistive micro sensor device includes a semiconductor chip; a through hole, which runs through the semiconductor chip from an upper side to a lower side; electrically conductive structures, wherein the middle section of each of the electrically conductive structures spans over the through hole at the upper side of the semiconductor chip; an electrically insulating arrangement for electrically insulating the electrically conductive structures and the semiconductor chip from each other, wherein the through hole runs through the electrically insulating arrangement; and a contact arrangement including contacts, wherein each of the contacts is electrically connected to one of the first end sections or one of the second end sections, so that electrical energy is fed to at least one of the electrically conductive structures to heat the respective electrically conductive structure, and so that an electrical resistance of one of the electrically conductive structures is measured at the contact arrangement.

Abstract: Playback devices such as headphone devices can include an earpiece configured to be positioned adjacent a user's ear. The earpiece can include a transducer having a diaphragm configured to face toward the user's ear when the earpiece is positioned adjacent the user's ear, as well as an outlet vent in fluid communication with the transducer and a microphone. A support member within the earpiece includes a first opening aligned with the microphone and a second opening aligned with the outlet vent. An acoustic mesh extends over the first opening and the second opening, wherein the mesh has a substantially uniform acoustic impedance.

Abstract: The injector unit according to the disclosure comprises a seat plate with a through opening extending through the seat plate, an armature element which can be placed onto the seat plate, in order to close the through opening, a spring element pushing the armature element in the direction of the seat plate, in order to close the through opening, an electromagnet designed to load the armature element with a force, in order to lift the armature element from the seat plate, and a stop for limiting a stroke of the armature element in a state in which it is lifted from the seat plate. The injector unit is characterized by a control unit designed to reduce an actuating signal of the electromagnet for lifting the armature element from the seat plate before the armature element contacts the stop for the first time after being lifted from the seat plate.

Abstract: A brake caliper is fastened to a stationary brake carrier by two fastening elements such that the caliper can slide axially relative to the brake disc. The fastening elements each have a guide bar fixedly connected to the brake carrier, of which guide bars, one guide bar is guided as a fixed bearing and the other guide bar is guided in a plain bearing, which is designed as a floating bearing having a floating bearing axis. The floating bearing has a guide bush, which reaches around the guide bar and is retained in a caliper bore such that sliding is prevented. A first tubular, variable-length seal is arranged on the end region of the guide bar far from the brake disc, which seals the guide bar from the environment and is fastened on the guide bar and in the guide bush. The first tubular, variable-length seal is clamped on the guide bar by a cap pressed into the guide bar.

Abstract: Playback devices such as headphone devices can include an earpiece configured to be positioned adjacent a user's ear. The earpiece can include a transducer having a diaphragm configured to face toward the user's ear when the earpiece is positioned adjacent the user's ear, as well as an outlet vent in fluid communication with the transducer and a microphone. A support member within the earpiece includes a first opening aligned with the microphone and a second opening aligned with the outlet vent. An acoustic mesh extends over the first opening and the second opening, wherein the mesh has a substantially uniform acoustic impedance.

Abstract: The present invention relates to a valve of a fuel injector for selectively disconnecting a high pressure region from a low pressure region of a fuel, comprising an opening in a seat plate, an armature which is designed to close the opening of the seat plate, a spring element which prestresses the armature in the direction of a position which closes the opening, and an electromagnet for lifting the armature out of the position which closes the opening into a position which releases the opening, characterized by an elastically compressible damping element for limiting an armature stroke in the case of the armature being lifted from the seat plate into the releasing position.

Abstract: A MEMS pump includes a basis structure, a membrane structure opposing the basis structure and being deflectable parallel to a surface normal of the basis structure and includes a pump chamber between the basis structure and the membrane structure wherein a volume of the pump chamber is based on a position of the membrane structure with respect to the basis structure. The MEMS pump includes a passage for letting a fluid pass into the pump chamber or exit the pump chamber, wherein the passage is arranged in-plane with respect to the pump chamber. The MEMS pump includes a valve structure coupled to the passage for connecting, in a first state, the passage to a first outer volume and for connecting, in a second state, the passage to a second outer volume.

Abstract: A thermoresistive micro sensor device includes a semiconductor chip; a through hole, which runs through the semiconductor chip from an upper side to a lower side; electrically conductive structures, wherein the middle section of each of the electrically conductive structures spans over the through hole at the upper side of the semiconductor chip; an electrically insulating arrangement for electrically insulating the electrically conductive structures and the semiconductor chip from each other, wherein the through hole runs through the electrically insulating arrangement; and a contact arrangement including contacts, wherein each of the contacts is electrically connected to one of the first end sections or one of the second end sections, so that electrical energy is fed to at least one of the electrically conductive structures to heat the respective electrically conductive structure, and so that an electrical resistance of one of the electrically conductive structures is measured at the contact arrangement.

Abstract: A brake caliper is fastened to a stationary brake carrier by two fastening elements such that the caliper can slide axially relative to the brake disc. The fastening elements each have a guide bar fixedly connected to the brake carrier, of which guide bars, one guide bar is guided as a fixed bearing and the other guide bar is guided in a plain bearing, which is designed as a floating bearing having a floating bearing axis. The floating bearing has a guide bush, which reaches around the guide bar and is retained in a caliper bore such that sliding is prevented. A first tubular, variable-length seal is arranged on the end region of the guide bar far from the brake disc, which seals the guide bar from the environment and is fastened on the guide bar and in the guide bush. The first tubular, variable-length seal is clamped on the guide bar by a cap pressed into the guide bar.

Abstract: The protective breathing mask with collective inhalation and exhalation hole is equipped with at least one hole, which serves at the same time to exhale and inhale and filter capability is achieved by using the removable filter consisting of nanofibre filter fabric.