Abstract: Disclosed are implant compositions and methods for treatment of neurological diseases of the central nervous system of a mammal.

Abstract: The present invention is directed to the use of choroid plexus cells and/or choroid plexus conditioned media for enhancing the growth, survival and/or maintenance of function of non-choroid plexus cells grown in long term or short term culture.

Abstract: Disclosed are implant compositions and methods for treatment of neurological diseases of the central nervous system of a mammal.

Abstract: The present invention is directed to a composition comprising high mannuronic acid-containing alginate and a polycation having a polydispersity index of less than 1.5. The composition is particularly useful for making biocompatible microcapsules containing living cells for allo- or xeno-transplantation. Such microcapsules have enhanced durability and can maintain their structural and functional integrity over long periods of time compared to prior art alginate microcapsules.

Abstract: A “supplementary choroid plexus” comprising preferably a xenotransplant of choroid plexus cells from a neonatal mammal provides a steady supply of trophic factors for administration to a central nervous system in need of treatment for a neurological disease. Choroid plexus cells manufacture a range of trophic factors, particularly during fetal development. This neurotrophic factor therapy may be useful in treating clinical and subclinical neurodegenerative diseases particularly those in which the choroid plexus has often become atrophic. The xenotransplant is cloaked in a protective layer (such as of alginate) capable of concealing the foreign nature of the transplant. Lateral ventricles are the preferred implantation site, from where the trophic factors are carried through the neuropil by the circulation of cerebrospinal fluid.

Abstract: The present invention is directed to the prevention or treatment of autoimmune diseases, and in particular, of type I diabetes, by administering a therapeutically effective amount of an implantable composition comprising living choroid plexus cells.

Abstract: The present invention is directed to the use of choroids plexus cells and/or choroids plexus conditioned media for enhancing the growth, survival and/or maintenance of function of non-choroid plexus cells grown in long term or short term culture.

Abstract: Disclosed are compositions and methods for the xenotransplantation treatment of neurological diseases of the central nervous system of a mammal.

Abstract: The invention relates to a novel method of administration, and device employed in the method, for administering a treatment species to the lungs of a recipient patient. The method involves introducing the device of the invention to the venous system of the patient, the size of the treatment species being such that, upon introduction to the venous system of the patient, the device will impact in a region of a lung capillary of the patient. The treatment species gains access to the lung and/or lung epithelia due to proteases associated with the treatments species. The application of the method to the treatment of cystic fibrosis is also claimed.

Abstract: The present invention is directed to the use of choroid plexus cells and/or choroid plexus conditioned media for enhancing the growth, survival and/or maintenance of function of non-choroid plexus cells grown in long term or short term culture.

Abstract: Aggregates and their method of preparation suitable for implantation into a recipient in order to produce insulin in vivo. The methods involve culturing islet cells isolated from the pancreas of donor piglets with isolated Sertoli cells from the testes of donor piglets. A preferred period of culturing is 5 days and may be followed by a purification procedure.

Abstract: The present invention is directed to the prevention or treatment of sensorineural hearing loss by administering a therapeutically effective amount of an implantable composition comprising encapsulated living choroid plexus cells.

Abstract: An accessory is provided to include, in combination, a permanently coiled helical hose and a hose caddy therefore. Such helical hoses are formed from a plurality of equal convolutions forming the helix, with these convolutions defining a central volume. The hose caddy has a base member designed to normally rest on the ground or other supporting surface. A staff member extends substantially perpendicular to the base member, this staff being adapted to be loosley inserted into the volume formed by the convolutions. As a combination of hose and caddy, the accessory can be moved to any location where needed. In addition, the combination is easy to store without having additional apparatus.

Abstract: A method of molding a high density composite article which, when completed, has opposed outer skins of fiber-reinforced plastics material and polymer mortar core between the skins. The method is performed by (a) providing an openable mold defining a mold cavity and an injection port through which polymer mortar may be introduced into the cavity; (b) opening the mold and placing within the cavity respective layers of fiber reinforcement to form the opposed outer skins; (c) closing the mold and injecting polymer mortar consisting of a resinous material loaded with high density particulate aggregate through the injection port into the cavity, between the layers of fiber reinforcement placed therein; and (d) applying sufficient pressure to the injected polymer mortar to ensure resin is separated from the polymer mortar and penetrates the said layers.

Abstract: A gardening accessory is provided in the form of a portable watering system including, in combination, a permanently coiled helical water hose and a hose caddy therefore. Such helical water hoses are formed from a plurality of equal convolutions forming the helix, with these convolutions defining a central volume. The hose caddy has a base member designed to normally rest on the ground or other supporting surface. A staff member extends substantially perpendicular to the base member, this staff being adapted to be inserted into the volume formed by the convolutions. As a combination of hose and caddy, the garden accessory can be moved to any location where watering is to be carried out. In addition, the combination is easy to store without having additional apparatus.

Abstract: Method of preparing and administering a treatment species to a mammalian recipient, the treatment species including one or more of:

Abstract: A method of moulding a high density composite article which, when completed, has opposed outer skins of fibre-reinforced plastics material and polymer mortar core between the skins. The method is performed by (a) providing an openable mould defining a mould cavity and an injection port through which polymer mortar may be introduced into the cavity; (b) opening the mould and placing within the cavity respective layers of fibre reinforcement to form the opposed outer skins; (c) closing the mould and injecting polymer mortar consisting of a resinous material loaded with high density particulate aggregate through the injection port into the cavity, between the layers of fibre reinforcement placed therein; and (d) applying sufficient pressure to the injected polymer mortar to ensure resin is separated from the polymer mortar and penetrates the said layers.

Abstract: A pipe construction system which utilises a multiplicity of arcuate pipe segments 11, 12 to form a pipe section 10 and which sections are assembled together to form a length of pipe. Each segment 11, 12 has two longitudinal edges 13 of increased radial thickness and having a groove 14 formed in the circumferential direction whereby an interlocking and sealing member 15 may be located in the aligned grooves 14 of two adjacent segments 11, 12. One end of a pipe section 10 assembled from the segments defines a socket 22 for receiving a spigot 23 defined at the other end of a like section. The spigot end of each segment has a pocket 25 formed along said edge 13 but within the thickness of the major area of the segment, which pocket 25 mates with a corresponding pocket 25 of an adjacent segment whereby sealant may be disposed in the mating pockets.