Abstract: Bicycle trainer comprising a seat, handlebars and rotatable pedals, and an electronically variable brake acting directly or indirectly on the rotatable pedals with a braking resistance that depends on a predetermined setting of a computer-controller, which predetermined setting is variable and depends on selected parameters to reflect simulated cycling conditions comprising at least one of a road, wind conditions and a cyclist, wherein the bicycle trainer excludes a flywheel and includes a variable-ratio transmission system and that the predetermined setting of the braking resistance also depends on a setting or change of setting of the variable-ratio transmission system so as to simulate a level of inertia or change of inertia as experienced by an outdoor cyclist when changing the variable-ratio transmission system.

Abstract: A direct-drive bicycle training system and methods of using the same are provided. The system includes a bicycle trainer that rests on a support surface and supports a bicycle frame in an upright manner with respect to the support surface. The bicycle trainer includes a stator, a rotor that rotates with respect to the stator, a cassette affixed to the rotor, a support frame supporting the stator, rotor, and cassette, and a resistance applying mechanism that operatively couples to a portion of a drivetrain of the bicycle frame and applies varying levels of resistance to the portion of the drivetrain. The support frame moves with respect to the support surface in response to a force applied to the drivetrain of the bicycle frame during use of the bicycle training system, generating a more natural movement of the bicycle and simulating on-road use.

Abstract: A direct-drive bicycle training system and methods of using the same are provided. The system includes a bicycle trainer that rests on a support surface and supports a bicycle frame in an upright manner with respect to the support surface. The bicycle trainer includes a stator, a rotor that rotates with respect to the stator, a cassette affixed to the rotor, a support frame supporting the stator, rotor, and cassette, and a resistance applying mechanism that operatively couples to a portion of a drivetrain of the bicycle frame and applies varying levels of resistance to the portion of the drivetrain. The support frame moves with respect to the support surface in response to a force applied to the drivetrain of the bicycle frame during use of the bicycle training system, generating a more natural movement of the bicycle and simulating on-road use.

Abstract: A direct-drive bicycle training system and methods of using the same are provided. The system includes a bicycle trainer that rests on a support surface and supports a bicycle frame in an upright manner with respect to the support surface. The bicycle trainer includes a stator, a rotor that rotates with respect to the stator, a cassette affixed to the rotor, a support frame supporting the stator, rotor, and cassette, and a resistance applying mechanism that operatively couples to a portion of a drivetrain of the bicycle frame and applies varying levels of resistance to the portion of the drivetrain. The support frame moves with respect to the support surface in response to a force applied to the drivetrain of the bicycle frame during use of the bicycle training system, generating a more natural movement of the bicycle and simulating on-road use.

Abstract: Power measurement device for a bicycle trainer, which device is built as a unitary relocatable device comprising an acceleration or velocity sensor, a microcontroller and a memory, wherein the device is equipped with or connectable to a power source, preferably a battery, and wherein the device is equipped with a communication facility to enable the device to wirelessly or through wires communicate with an external application device.

Abstract: A bicycle training system and methods of using the same. The system includes a movement platform that rests on a support surface and supports a bicycle in an upright manner with respect to the support surface. The movement platform includes a support frame having a base and at least one upstanding arm that supportably engages a portion of a frame of the bicycle, a resistance assembly operatively coupled to a portion of a drivetrain of the bicycle that applies varying levels of resistance to the portion of the drivetrain, and a plurality of bushings isolating the base from the support surface. The plurality of bushings are spherical thereby permitting the movement platform to move with respect to the support surface in response to forces applied to the bicycle frame during use of the bicycle training system.

Abstract: A bicycle training system and methods of using the same. The system includes a movement platform that rests on a support surface and supports a bicycle in an upright manner with respect to the support surface. The movement platform includes a support frame having a base and at least one upstanding arm that supportably engages a portion of a frame of the bicycle, a resistance assembly operatively coupled to a portion of a drivetrain of the bicycle that applies varying levels of resistance to the portion of the drivetrain, and a plurality of bushings isolating the base from the support surface. The plurality of bushings are spherical thereby permitting the movement platform to move with respect to the support surface in response to forces applied to the bicycle frame during use of the bicycle training system.

Abstract: Method for operating a bicycle trainer, and such a bicycle trainer comprising a stand with a seat, handlebars and rotatable pedals, or such a bicycle trainer comprising a stand for mounting a bicycle frame with a seat, handlebars and rotatable pedals, wherein the stand incorporates an electronically variable brake acting directly or indirectly on the rotatable pedals with a braking resistance that depends on a computer-controlled predetermined setting, wherein the pre-determined setting is variable and wherein said setting depends on selected parameters to reflect a simulated surface condition of a road.

Abstract: A direct-drive bicycle training system and methods of using the same are provided. The system includes a bicycle trainer that rests on a support surface and supports a bicycle frame in an upright manner with respect to the support surface. The bicycle trainer includes a stator, a rotor that rotates with respect to the stator, a cassette affixed to the rotor, a support frame supporting the stator, rotor, and cassette, and a resistance applying mechanism that operatively couples to a portion of a drivetrain of the bicycle frame and applies varying levels of resistance to the portion of the drivetrain. The support frame moves with respect to the support surface in response to a force applied to the drivetrain of the bicycle frame during use of the bicycle training system, generating a more natural movement of the bicycle and simulating on-road use.

Abstract: Bicycle trainer comprising a seat, handlebars and rotatable pedals, and an electronically variable brake acting directly or indirectly on the rotatable pedals with a braking resistance that depends on a predetermined setting of a computer-controller, which predetermined setting is variable and depends on selected parameters to reflect simulated cycling conditions comprising at least one of a road, wind conditions and a cyclist, wherein the bicycle trainer excludes a flywheel and includes a variable-ratio transmission system and that the predetermined setting of the braking resistance also depends on a setting or change of setting of the variable-ratio transmission system so as to simulate a level of inertia or change of inertia as experienced by an outdoor cyclist when changing the variable-ratio transmission system.

Abstract: Power measurement device for a bicycle trainer, which device is built as a unitary relocatable device comprising an acceleration or velocity sensor, a microcontroller and a memory, wherein the device is equipped with or connectable to a power source, preferably a battery, and wherein the device is equipped with a communication facility to enable the device to wirelessly or through wires communicate with an external application device.

Abstract: Method for operating a bicycle trainer, and such a bicycle trainer comprising a stand with a seat, handlebars and rotatable pedals, or such a bicycle trainer comprising a stand for mounting a bicycle frame with a seat, handlebars and rotatable pedals, wherein the stand incorporates an electronically variable brake acting directly or indirectly on the rotatable pedals with a braking resistance that depends on a computer-controlled predetermined setting, wherein the pre-determined setting is variable and wherein said setting depends on selected parameters to reflect a simulated surface condition of a road.

Abstract: Method for operating a bicycle trainer, and such a bicycle trainer comprising a stand with a seat, handlebars and rotatable pedals, or such a bicycle trainer comprising a stand for mounting a bicycle frame with a seat, handlebars and rotatable pedals, wherein the stand incorporates an electronically variable brake acting directly or indirectly on the rotatable pedals with a braking resistance that depends on a computer-controlled predetermined setting, wherein the pre-determined setting is variable and wherein said setting depends on selected parameters to reflect a simulated surface condition of a road.

Abstract: The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting CXCR7 mediated tumour growth.

Abstract: A bicycle trainer for removably loading a bicycle with at least a back wheel, where the bicycle trainer comprises a floorstanding frame with a wheel supporting roller at a rear end and a fork supporting unit at a front end, wherein the fork supporting unit is pivotally supported by the floorstanding frame enabling the fork supporting unit to move, where the fork supporting unit and the floorstanding frame connect to each other with a hinge enabling movement of the fork supporting unit in a longitudinal direction of the floorstanding frame, wherein the fork supporting unit is spring-loaded with a spring at or near the hinge to provide the fork supporting unit with a preferential upright position at right angles with the floorstanding frame such that whenever the bicycle is moved, said bicycle returns to an average position on the bicycle trainer with the fork support unit perpendicular to the floorstanding frame.

Abstract: The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting CXCR7 mediated tumor growth.

Abstract: The present invention relates to amino acid sequences that are directed against (as defined herein) human cellular receptors for viruses and/or bacteria such as e.g. Nanobodies specifically recognizing hCD4, hCXCR4, hCCR5, hTLR4, human alphaV integrin, human beta3 integrin, human beta1 integrin, human alpha2 integrin, hCD81, hSR-BI, hClaudin-1, hClaudin-6 and hClaudin-9, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. Amino acid sequences of the present invention may be used to prevent human cell entry of HIV, HCV, adenoviruses, hantavirus, herpesvirus, echo-virus 1 and others.

Abstract: The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes.

Abstract: Method for operating a bicycle trainer, and such a bicycle trainer comprising a stand with a seat, handlebars and rotatable pedals, or such a bicycle trainer comprising a stand for mounting a bicycle frame with a seat, handlebars and rotatable pedals, wherein the stand incorporates an electronically variable brake acting directly or indirectly on the rotatable pedals with a braking resistance that depends on a computer-controlled predetermined setting, wherein the pre-determined setting is variable and wherein said setting depends on selected parameters to reflect a simulated surface condition of a road.

Abstract: A bicycle trainer for removably loading with a bicycle that is at least provided with a back wheel, which bicycle trainer comprises a floorstanding frame with a wheel supporting roller at its rear end and a fork supporting unit at its forward end, wherein the fork supporting unit is pivotally supported by the frame enabling it to move back-and-forth. The fork supporting unit and the frame connect to each other with a hinge enabling back-and-forth movement of the fork supporting unit in a longitudinal direction of the frame, wherein the fork supporting unit is spring-loaded with a spring at or near the hinge to provide the fork supporting unit with a preferential upright position at square angles with the frame so as to arrange that in use whenever the bicycle is moved forward or backward, said bicycle is inclined to return to an average position on the bicycle trainer wherein the fork support unit is perpendicular to the horizon.