Abstract: The present application discloses neutralizing anti-SARS-COV-2 antibodies or antigen-binding fragments thereof that are effective against several SARS-COV-2 variants. Pharmaceutical compositions comprising the antibodies or antigen-binding fragments thereof are also disclosed. The antibodies, antigen-binding fragments thereof, or pharmaceutical compositions described herein may be used for the prevention and/or treatment of coronavirus infection and/or associated diseases and symptoms, such as SARS-COV-2 infection and/or COVID-19.

Abstract: A method for generating and using multi-view masters involves selecting a master in a design environment. A widget is added to the master. A first view is selected for the master. A first widget characterization of the widget is received. The first widget characterization is associated with the first view of the master. A second view of the master is selected. A second widget characterization of the widget is received. The second widget characterization is associated with the second view of the master. An instance of the master is placed in a containing context. A first instance view selection is received, the first instance view selecting the first view of the master for the first instance of the master. The first instance of the master is displayed within the containing context, the widget being displayed in accordance with the first widget characterization associated with the first view of the master.

Abstract: Computer-implemented methods for allowing users to specify interactive graphical designs are provided. The graphical designs can comprise multiple dimension versions—such as a tablet dimension version or a phone dimension version. Some of the methods involve an inheritance structure that defines a first dimension version of the design as a child of a second dimension version of the design. Specifications for properties of widgets in the graphical design are applied to the design in accordance with the inheritance specification. Some of the methods involve an inheritance characterization that determines how properties of a widget are affected by the inheritance structure across different dimension versions. Some of the methods involve an existence property for the widgets.

Abstract: An integrated monitoring panel for an elevator hoistway fire detection system is provided. The system includes a power supply, fault indicators for power and smoke detection, and alarm indicators for smoke and linear heat detection. The panel is configured to receive a terminus of a linear heat detection cable and a terminus of a smoke alarm detection piping. The panel includes a smoke detection test port that may receive simulated smoke and is connected to another terminus of the smoke alarm detection piping. A linear heat detection test switch triggers a test mode and interacts with the linear heat detection cable. During the test mode, the system circulates simulated smoke, analyzes air quality and electrical conditions, and activates corresponding alarm indicators. The performance of these functionalities helps determine whether the system meets operational criteria.

Abstract: A system for analyzing the concentration of a first component in a sample fluid is described. The system provides a mixture of sample fluid and control fluid to a fluid concentration measuring apparatus in a controlled ratio. The system stores flow change model, representing the variation in time of the flow of the sample fluid through the system between a valving and the fluid concentration measuring apparatus in response to a variation of the controlled rate by the valving. The system estimates the concentration of the first component in the sample fluid based at least in part on the controlled ratio, and the flow change model.

Abstract: Disclosed is a device for determining a concentration of cells of a given size in a sample of fluid, the sample comprising a plurality of cells, comprising: a light source arranged to emit light along a central axis to illuminate the plurality of cells in the fluid sample; a detector arranged to receive light at a plurality of displacements from the central axis, the light having passed through the plurality of cells in the fluid sample, and to produce a plurality of signals, each associated with, and indicative of an intensity of the received light at, a respective one of the plurality of displacements; and a processor arranged to determine a concentration of cells of a given size, based on the plurality of signals from the detector, wherein the processor is arranged to compare the plurality of signals from the detector with one or more pre-stored thresholds or profiles, indicative of a particular concentration.

Abstract: A sectional radiator seal arrangement including a sectional radiator having a core and a bonnet, a nozzle defined by a cylindrical sidewall extending from and in fluid communication with the bonnet and the core, the nozzle configured for creating a seal with a radiator tank and a sleeve formed from a corrosion resistant material fitted about a portion of the cylindrical sidewall of the nozzle. A retaining compound can be provided between the sleeve and the radiator tank for preventing an ingress of coolant at the seal and into contact with either the nozzle or the bonnet. A method of reducing corrosion of the radiator seal also is provided.

Abstract: A method involves identifying state views of a stateful widget container in a design tool having a canvas design context and an all-states view design context, each state view of the stateful widget container being associated with a unique state of the stateful widget container. A first state view of the stateful widget container is displayed in the canvas design context, no other state view of the stateful widget container being displayed concurrently in the canvas design context. The state views of the stateful widget container are displayed concurrently in the all-states view design context, an internal widget layout of each state view corresponding to that displayed in the canvas design context. A first user input is received at a first interactive widget within the stateful widget container in the all-states view design context, the first interactive widget being associated with the first state view of the stateful widget container.

Abstract: A focused specification for an interactive graphical design is generated by receiving a first user input from a user, the first user input identifying a first design element of the interactive graphical design. A set of selectable data elements associated with the first design element is identified and a specification template that includes the set of selectable data elements is generated. A second user input is received from the user, the second user input identifying a set of selected data elements using the generated specification template. The set of selected data elements includes one or more of the selectable data elements. The focused specification is generated using the set of selected data elements, the focused specification including the set of selected data elements and excluding selectable data elements that were not selected.

Abstract: A method for generating and using multi-view masters involves selecting a master in a design environment. A widget is added to the master. A first view is selected for the master. A first widget characterization of the widget is received. The first widget characterization is associated with the first view of the master. A second view of the master is selected. A second widget characterization of the widget is received. The second widget characterization is associated with the second view of the master. An instance of the master is placed in a containing context. A first instance view selection is received, the first instance view selecting the first view of the master for the first instance of the master. The first instance of the master is displayed within the containing context, the widget being displayed in accordance with the first widget characterization associated with the first view of the master.

Abstract: This disclosure relates to methods and systems for processing of sequencing data streams. The system receives sequences from a sequencer and stores them as data records on a database. The sequences are associated with a counter indicative of a number of times the associated sequence has been sequenced. The system progressively receives a further sequence as streaming data from the sequence. While receiving the further sequence, the system matches the streaming data against the stored sequences to determine a matching score. Upon the matching score exceeding a matching threshold for one of the multiple sequences in the database, the system selects the one of the sequences in the database based on the matching score and stores the further sequence on non-volatile memory where the counter value associated with the selected sequence is below a saturation threshold. The system also terminates the receiving where the counter value is above the saturation threshold.

Abstract: A method for generating and using multi-view masters involves selecting a master in a design environment. A widget is added to the master. A first view is selected for the master. A first widget characterization of the widget is received. The first widget characterization is associated with the first view of the master. A second view of the master is selected. A second widget characterization of the widget is received. The second widget characterization is associated with the second view of the master. An instance of the master is placed in a containing context. A first instance view selection is received, the first instance view selecting the first view of the master for the first instance of the master. The first instance of the master is displayed within the containing context, the widget being displayed in accordance with the first widget characterization associated with the first view of the master.

Abstract: Computer-implemented methods for allowing users to specify interactive graphical designs are provided. The graphical designs can comprise multiple dimension versions—such as a tablet dimension version or a phone dimension version. Some of the methods involve an inheritance structure that defines a first dimension version of the design as a child of a second dimension version of the design. Specifications for properties of widgets in the graphical design are applied to the design in accordance with the inheritance specification. Some of the methods involve an inheritance characterization that determines how properties of a widget are affected by the inheritance structure across different dimension versions. Some of the methods involve an existence property for the widgets.

Abstract: Computer-implemented methods for allowing users to specify interactive graphical designs are provided. The graphical designs can comprise multiple dimension versions—such as a tablet dimension version or a phone dimension version. Some of the methods involve an inheritance structure that defines a first dimension version of the design as a child of a second dimension version of the design. Specifications for properties of widgets in the graphical design are applied to the design in accordance with the inheritance specification. Some of the methods involve an inheritance characterization that determines how properties of a widget are affected by the inheritance structure across different dimension versions. Some of the methods involve an existence property for the widgets.

Abstract: A method involves identifying state views of a stateful widget container in a design tool having a canvas design context and an all-states view design context, each state view of the stateful widget container being associated with a unique state of the stateful widget container. A first state view of the stateful widget container is displayed in the canvas design context, no other state view of the stateful widget container being displayed concurrently in the canvas design context. The state views of the stateful widget container are displayed concurrently in the all-states view design context, an internal widget layout of each state view corresponding to that displayed in the canvas design context. A first user input is received at a first interactive widget within the stateful widget container in the all-states view design context, the first interactive widget being associated with the first state view of the stateful widget container.

Abstract: A method for generating and using multi-view masters involves selecting a master in a design environment. A widget is added to the master. A first view is selected for the master. A first widget characterization of the widget is received. The first widget characterization is associated with the first view of the master. A second view of the master is selected. A second widget characterization of the widget is received. The second widget characterization is associated with the second view of the master. An instance of the master is placed in a containing context. A first instance view selection is received, the first instance view selecting the first view of the master for the first instance of the master. The first instance of the master is displayed within the containing context, the widget being displayed in accordance with the first widget characterization associated with the first view of the master.

Abstract: The present disclosure relates to an improved methodology for phenotyping and molecular characterisation of single cells using high-throughput and multiplexed targeted long-read single cell sequencing. In one particular example, the present disclosure relates to a methodology which combines targeted long-read sequencing with short-read based transcriptome profiling of barcoded single cell libraries generated by droplet-based partitioning for high throughput deep single cell profiling.

Abstract: A system comprises a first workstation that locally instantiates a design tool configured to allow a designer to specify a design for a web page. A data store is locally available to the first workstation, and receives and stores the design as a saved design. A second workstation provides access to a code editor to allow a programmer to specify a modification to an encoding of the design. A server means instantiates the code editor for the second workstation, saves the modification as a saved modification, and serves the encoding of the design in accordance with the modification by combining the saved modification with the saved design. The server means seamlessly combines the saved design and the saved modification such that the saved modification and the saved design can each be independently altered and recombined to produce a modified encoding of the design.

Abstract: A method for generating and using multi-view masters involves selecting a master in a design environment. A widget is added to the master. A first view is selected for the master. A first widget characterization of the widget is received. The first widget characterization is associated with the first view of the master. A second view of the master is selected. A second widget characterization of the widget is received. The second widget characterization is associated with the second view of the master. An instance of the master is placed in a containing context. A first instance view selection is received, the first instance view selecting the first view of the master for the first instance of the master. The first instance of the master is displayed within the containing context, the widget being displayed in accordance with the first widget characterization associated with the first view of the master.

Abstract: Various methods and systems for documenting interactive graphical design include an exemplary graphical design environment stored on a non-transitory computer-readable medium that comprises a documentation element in an interactive graphical design. The design environment also comprises a design element that displays a plurality of states in a rendering of the interactive graphical design in an external player. The documentation element: (i) is enabled to receive a selection from the user of a state in the plurality of states; and (ii) displays a representation of the design element in the state in response to receiving the selection from the user. The documentation element and design element are both instantiated by a processor operating in combination with the non-transitory computer-readable medium.