Patents by Inventor Martin Stanton
Martin Stanton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11613748Abstract: The present invention provides a method for producing a nucleic acid molecule that can obtain a nucleic acid molecule that binds to a target and does not inhibit a function of the target. The production method for a nucleic acid molecule of the present invention is a method for producing a nucleic acid molecule that binds to a first biological molecule and does not inhibit a function of the first biological molecule, the method including the steps of: (A) bringing a candidate nucleic acid molecule into contact with the first biological molecule to select a nucleic acid molecule that has bound to the first biological molecule as a first selected nucleic acid molecule; and (B) selecting the first selected nucleic acid molecule as an intended nucleic acid molecule.Type: GrantFiled: October 30, 2019Date of Patent: March 28, 2023Assignees: NEC Solution Innovators, Ltd., MOSAIC BIOSCIENCES, INC.Inventors: Tomoko Fujita, Iwao Waga, Katsunori Horii, Martin Stanton, Andrew Dalby
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Publication number: 20220396792Abstract: The present invention provides a method for producing a nucleic acid molecule that can obtain a nucleic acid molecule that binds to a target and does not inhibit a function of the target. The production method for a nucleic acid molecule of the present invention is a method for producing a nucleic acid molecule that binds to a first biological molecule and does not inhibit a function of the first biological molecule, the method including the steps of: (A) bringing a candidate nucleic acid molecule into contact with the first biological molecule to select a nucleic acid molecule that has bound to the first biological molecule as a first selected nucleic acid molecule; and (B) selecting the first selected nucleic acid molecule as an intended nucleic acid molecule.Type: ApplicationFiled: October 29, 2020Publication date: December 15, 2022Applicants: NEC Solution Innovators, Ltd., MOSAIC BIOSCIENCES, INC.Inventors: Tomoko FUJITA, Iwao WAGA, Katsunori HORII, Shintaro KATO, Martin STANTON, Andrew B. DALBY
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Patent number: 11439711Abstract: Provided are methods for linking polypeptides (including peptides and proteins) to other moieties using radical imitated thiol-ene chemistries, for example, modifying a polypeptide by introducing reactive thiol groups and reacting the thiol groups with olefin-containing reagents or alkyne-containing reagents under conditions that support radical thiol-ene or thiol-yne reactions. The reactive thiol groups have greater activity for radical thiol-ene reactions that a cysteine thiol group, including thiol groups that are separated from the peptide backbone by at least two carbon atoms, for example, the thiol group of a homocysteine residue. Also provided are compositions and biomaterials containing the linked polypeptides, for example, peptide and protein conjugates, and thiol-ene based biocompatible hydrogel polymers, and their uses in the medical field.Type: GrantFiled: October 30, 2020Date of Patent: September 13, 2022Assignee: Mosaic Biosciences, Inc.Inventors: Alexei V. Kazantsev, Peter D. Mariner, Martin Stanton
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Publication number: 20220241466Abstract: The present disclosure relates generally to degradable polymeric scaffolds, methods of making them, and their use in the biomedical field.Type: ApplicationFiled: May 14, 2020Publication date: August 4, 2022Inventors: Peter D. MARINER, Alexei KAZANTSEV, Martin STANTON, Zheng ZHANG, Chrysa LATRICK
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Publication number: 20220227838Abstract: The present disclosure provides a method of covalently modifying a biological macromolecule, the method comprising subjecting a reaction mixture comprising: (a) a biological macromolecule comprising one or more thiol groups; and (b) a molecule comprising one or more olefin or alkyne moieties to a radical reaction under conditions sufficient to produce the covalently modified biological macromolecule. The present disclosure also provides a method of covalently modifying a biological macromolecule, the method comprising subjecting a reaction mixture comprising: (a) a molecule comprising one or more thiol groups; and (b) biological macromolecule comprising one or more olefin or alkyne moieties to a radical reaction under conditions sufficient to produce the covalently modified biological macromolecule. The present disclosure further provides a covalently modified biological macromolecule prepared by any of disclosed methods.Type: ApplicationFiled: August 26, 2021Publication date: July 21, 2022Inventors: Alexei KAZANTSEV, Peter D. MARINER, Martin STANTON
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Patent number: 11160866Abstract: The disclosure provides biomaterials including scaffolds that include blood products including blood fractions and products including platelets for administration to subjects in need thereof. More specifically, the scaffolds based on step growth polymers are enriched with blood extracts that contain platelet rich plasma (PRP) and/or extracts of platelets. Compositions comprising a biomaterial or precursor thereof and a blood extract are provided, as are methods of making and using the biopolymers or precursors thereof. Kits and articles of manufacture comprising the biopolymers or precursors thereof are also described.Type: GrantFiled: May 7, 2018Date of Patent: November 2, 2021Assignee: Mosaic Biosciences, Inc.Inventors: Peter D. Mariner, Martin Stanton, Alexei Kazantsev, Jeanne Callan
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Patent number: 11130797Abstract: The present disclosure provides a method of covalently modifying a biological macromolecule, the method comprising subjecting a reaction mixture comprising: (a) a biological macromolecule comprising one or more thiol groups; and (b) a molecule comprising one or more olefin or alkyne moieties to a radical reaction under conditions sufficient to produce the covalently modified biological macromolecule. The present disclosure also provides a method of covalently modifying a biological macromolecule, the method comprising subjecting a reaction mixture comprising: (a) a molecule comprising one or more thiol groups; and (b) a biological macromolecule comprising one or more olefin or alkyne moieties to a radical reaction under conditions sufficient to produce the covalently modified biological macromolecule. The present disclosure further provides a covalently modified biological macromolecule prepared by any of the disclosed methods.Type: GrantFiled: May 4, 2018Date of Patent: September 28, 2021Assignee: MOSAIC BIOSCIENCES, INC.Inventors: Alexei Kazantsev, Peter D. Mariner, Martin Stanton
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Publication number: 20210154306Abstract: Provided are methods for linking polypeptides (including peptides and proteins) to other moieties using radical imitated thiol-ene chemistries, for example, modifying a polypeptide by introducing reactive thiol groups and reacting the thiol groups with olefin-containing reagents or alkyne-containing reagents under conditions that support radical thiol-ene or thiol-yne reactions. The reactive thiol groups have greater activity for radical thiol-ene reactions that a cysteine thiol group, including thiol groups that are separated from the peptide backbone by at least two carbon atoms, for example, the thiol group of a homocysteine residue. Also provided are compositions and biomaterials containing the linked polypeptides, for example, peptide and protein conjugates, and thiol-ene based biocompatible hydrogel polymers, and their uses in the medical field.Type: ApplicationFiled: October 30, 2020Publication date: May 27, 2021Inventors: Alexei V. KAZANTSEV, Peter D. MARINER, Martin STANTON
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Publication number: 20210130820Abstract: The present invention provides a method for producing a nucleic acid molecule that can obtain a nucleic acid molecule that binds to a target and does not inhibit a function of the target. The production method for a nucleic acid molecule of the present invention is a method for producing a nucleic acid molecule that binds to a first biological molecule and does not inhibit a function of the first biological molecule, the method including the steps of: (A) bringing a candidate nucleic acid molecule into contact with the first biological molecule to select a nucleic acid molecule that has bound to the first biological molecule as a first selected nucleic acid molecule; and (B) selecting the first selected nucleic acid molecule as an intended nucleic acid molecule.Type: ApplicationFiled: October 30, 2019Publication date: May 6, 2021Applicants: NEC Solution Innovators, Ltd., MOSAIC BIOSCIENCES, INC.Inventors: Tomoko FUJITA, Iwao WAGA, Katsunori HORII, Martin STANTON, Andrew DALBY
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Patent number: 10912837Abstract: Provided are methods for linking polypeptides (including peptides and proteins) to other moieties using radical imitated thiol-ene chemistries, for example, modifying a polypeptide by introducing reactive thiol groups and reacting the thiol groups with olefin-containing reagents or alkyne-containing reagents under conditions that support radical thiol-ene or thiol-yne reactions. The reactive thiol groups have greater activity for radical thiol-ene reactions that a cysteine thiol group, including thiol groups that are separated from the peptide backbone by at least two carbon atoms, for example, the thiol group of a homocysteine residue. Also provided are compositions and biomaterials containing the linked polypeptides, for example, peptide and protein conjugates, and thiol-ene based biocompatible hydrogel polymers, and their uses in the medical field.Type: GrantFiled: February 9, 2016Date of Patent: February 9, 2021Assignee: MOSAIC BIOSCIENCES, INC.Inventors: Alexei V. Kazantsev, Peter D. Mariner, Martin Stanton
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Publication number: 20180360970Abstract: The disclosure provides biomaterials including scaffolds that include blood products including blood fractions and products including platelets for administration to subjects in need thereof. More specifically, the scaffolds based on step growth polymers are enriched with blood extracts that contain platelet rich plasma (PRP) and/or extracts of platelets. Compositions comprising a biomaterial or precursor thereof and a blood extract are provided, as are methods of making and using the biopolymers or precursors thereof. Kits and articles of manufacture comprising the biopolymers or precursors thereof are also described.Type: ApplicationFiled: May 7, 2018Publication date: December 20, 2018Applicant: Mosaic Biosciences, Inc.Inventors: Peter D. MARINER, Martin STANTON, Alexei KAZANTSEV, Jeanne CALLAN
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Publication number: 20180355019Abstract: The present disclosure provides a method of covalently modifying a biological macromolecule, the method comprising subjecting a reaction mixture comprising: (a) a biological macromolecule comprising one or more thiol groups; and (b) a molecule comprising one or more olefin or alkyne moieties to a radical reaction under conditions sufficient to produce the covalently modified biological macromolecule. The present disclosure also provides a method of covalently modifying a biological macromolecule, the method comprising subjecting a reaction mixture comprising: (a) a molecule comprising one or more thiol groups; and (b) a biological macromolecule comprising one or more olefin or alkyne moieties to a radical reaction under conditions sufficient to produce the covalently modified biological macromolecule. The present disclosure further provides a covalently modified biological macromolecule prepared by any of the disclosed methods.Type: ApplicationFiled: May 4, 2018Publication date: December 13, 2018Inventors: Alexei KAZANTSEV, Peter D. MARINER, Martin STANTON
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Patent number: 10100316Abstract: Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.Type: GrantFiled: April 21, 2004Date of Patent: October 16, 2018Assignee: Archemix LLCInventors: David Epstein, Dilara Grate, Martin Stanton, John L. Diener, Charles Wilson, Thomas Greene McCauley, Errol Desouza
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Patent number: 10016505Abstract: The disclosure provides biomaterials including scaffolds that include blood products including blood fractions and products including platelets for administration to subjects in need thereof. More specifically, the scaffolds based on step growth polymers are enriched with blood extracts that contain platelet rich plasma (PRP) and/or extracts of platelets. Compositions comprising a biomaterial or precursor thereof and a blood extract are provided, as are methods of making and using the biopolymers or precursors thereof. Kits and articles of manufacture comprising the biopolymers or precursors thereof are also described.Type: GrantFiled: February 4, 2013Date of Patent: July 10, 2018Assignee: MOSAIC BIOSCIENCES, INC.Inventors: Peter D. Mariner, Martin Stanton, Alexei Kazantsev, Jeanne Callan
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Patent number: 9988433Abstract: The present disclosure provides a method of covalently modifying a biological macromolecule, the method comprising subjecting a reaction mixture comprising: (a) a biological macromolecule comprising one or more thiol groups; and (b) a molecule comprising one or more olefin or alkyne moieties to a radical reaction under conditions sufficient to produce the covalently modified biological macromolecule. The present disclosure also provides a method of covalently modifying a biological macromolecule, the method comprising subjecting a reaction mixture comprising: (a) a molecule comprising one or more thiol groups; and (b) a biological macromolecule comprising one or more olefin or alkyne moieties to a radical reaction under conditions sufficient to produce the covalently modified biological macromolecule. The present disclosure further provides a covalently modified biological macromolecule prepared by any of the disclosed methods.Type: GrantFiled: March 13, 2014Date of Patent: June 5, 2018Assignee: Mosaic Biosciences, Inc.Inventors: Alexei Kazantsev, Peter D. Mariner, Martin Stanton
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Publication number: 20180043030Abstract: Provided are methods for linking polypeptides (including peptides and proteins) to other moieties using radical imitated thiol-ene chemistries, for example, modifying a polypeptide by introducing reactive thiol groups and reacting the thiol groups with olefin-containing reagents or alkyne-containing reagents under conditions that support radical thiol-ene or thiol-yne reactions. The reactive thiol groups have greater activity for radical thiol-ene reactions that a cysteine thiol group, including thiol groups that are separated from the peptide backbone by at least two carbon atoms, for example, the thiol group of a homocysteine residue. Also provided are compositions and biomaterials containing the linked polypeptides, for example, peptide and protein conjugates, and thiol-ene based biocompatible hydrogel polymers, and their uses in the medical field.Type: ApplicationFiled: February 9, 2016Publication date: February 15, 2018Inventors: Alexei V. KAZANTSEV, Peter D. MARINER, Martin STANTON
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Patent number: 9404919Abstract: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non-nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.Type: GrantFiled: February 10, 2014Date of Patent: August 2, 2016Assignee: SOMALOGIC, INC.Inventors: Daniel J. Schneider, Dan Nieuwlandt, Bruce Eaton, Martin Stanton, Shashi Gupta, Stephan Kraemer, Dominic Zichi, Larry Gold
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Publication number: 20140273153Abstract: The present disclosure provides a method of covalently modifying a biological macromolecule, the method comprising subjecting a reaction mixture comprising: (a) a biological macromolecule comprising one or more thiol groups; and (b) a molecule comprising one or more olefin or alkyne moieties to a radical reaction under conditions sufficient to produce the covalently modified biological macromolecule. The present disclosure also provides a method of covalently modifying a biological macromolecule, the method comprising subjecting a reaction mixture comprising: (a) a molecule comprising one or more thiol groups; and (b) a biological macromolecule comprising one or more olefin or alkyne moieties to a radical reaction under conditions sufficient to produce the covalently modified biological macromolecule. The present disclosure further provides a covalently modified biological macromolecule prepared by any of the disclosed methods.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: Mosaic Biosciences, Inc.Inventors: Alexei KAZANTSEV, Peter D. MARINER, Martin STANTON
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Publication number: 20140249043Abstract: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non-nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.Type: ApplicationFiled: February 10, 2014Publication date: September 4, 2014Applicant: SOMALOGIC, INC.Inventors: Daniel J. Schneider, Dan Nieuwlandt, Bruce Eaton, Martin Stanton, Shashi Gupta, Stephan Kraemer, Dominic Zichi, Larry Gold
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Patent number: 8644595Abstract: In one aspect, a method of displaying data is provided. The method comprises obtaining projection data of an object by exposing an object to radiation at a plurality of view angles and detecting at least some of the radiation exiting the object to form the projection data, operating a computer to reconstruct the projection data at a reconstruction resolution to form image data comprising a plurality of voxels representing locations within the object, each of the plurality of voxels being assigned an associated intensity indicative of a density of the subject matter at the respective location, determining a maximum resolution for display, above which variation in intensity between adjacent voxels is not supported by information in the projection data, the maximum resolution being less than the reconstruction resolution, and displaying the image data at or below the maximum resolution.Type: GrantFiled: May 7, 2012Date of Patent: February 4, 2014Assignee: Dexela LimitedInventors: Martin Stanton, Alexander Stewart, Edward Bullard