Patents by Inventor Martin Stengelin
Martin Stengelin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240027456Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.Type: ApplicationFiled: October 4, 2023Publication date: January 25, 2024Applicant: Meso Scale Technologies, LLC.Inventors: Anahit Aghvanyan, Eli N. Glezer, John Kenten, Sudeep Kumar, Galina Nikolenko, Martin Stengelin, Srikant Vaithilingam
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Patent number: 11802877Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.Type: GrantFiled: May 26, 2020Date of Patent: October 31, 2023Assignee: MESO SCALE TECHNOLOGIES, LLC.Inventors: Anahit Aghvanyan, Eli N. Glezer, John Kenten, Sudeep Kumar, Galina Nikolenko, Martin Stengelin, Srikant Vaithilingam
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Publication number: 20230021837Abstract: The invention relates to assay methods and kits for assessing autoimmune diseases in a human subject. In embodiments, the present disclosure provides assay methods and kits for diagnosing a subject with or predicting that a subject will develop Type 1 diabetes. In embodiments, the present disclosure provides assay methods and kits for assessing responsiveness of a subject having Type 1 diabetes to treatment with alefacept. In embodiments, the present disclosure provides assay methods and kits for diagnosing a subject with systemic lupus erythematosus. In embodiments, the present disclosure provides assay methods and kits for determining if a subject is at risk of a systemic lupus erythematosus flare. In embodiments, the present disclosure provides assay methods and kits for diagnosing a subject with celiac disease.Type: ApplicationFiled: November 25, 2020Publication date: January 26, 2023Inventors: Anu MATHEW, Mingyue WANG, Christopher CAMPBELL, Katarzyna HAYNESWORTH, Nikhil PADMANABHAN, Martin STENGELIN, Paridhi GUPTA, Rashmi SRIRAM
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Publication number: 20220397579Abstract: The invention relates to methods and kits for quantitating radiation exposure in a subject exposed to radiation, at risk of exposure to radiation or suspected of having been exposed to radiation. In embodiments, the present disclosure provides multiplexed immunoassays for quantifying amounts of biomarkers for assessing radiation exposure in a sample. Also provided herein are kits for performing the multiplexed assays.Type: ApplicationFiled: November 4, 2020Publication date: December 15, 2022Inventors: Sunsanee Kanjananimmanont, Sudeep Kumar, Navaratnam Manjula, Simone Barbero, Martin Stengelin, George Sigal
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Patent number: 11525825Abstract: The present invention is directed to kits for improving assay specificity and performance in binding assays.Type: GrantFiled: September 9, 2019Date of Patent: December 13, 2022Assignee: MESO SCALE TECHNOLOGIES, LLC.Inventors: Anahit Aghvanyan, Eli N. Glezer, John Kenten, George Sigal, Martin Stengelin, David Routenberg
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Publication number: 20220357318Abstract: The present invention is directed to methods for improving assay specificity and performance in binding assays.Type: ApplicationFiled: July 21, 2022Publication date: November 10, 2022Inventors: Anahit AGHVANYAN, Eli N. GLEZER, John KENTEN, George SIGAL, Martin STENGELIN, David ROUTENBERG
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Publication number: 20220003766Abstract: The invention relates to methods and kits for detecting a virus, e.g., a respiratory virus such as a coronavirus, in a biological sample. The invention also relates to methods and kits for detecting and/or quantifying biomarkers, e.g., antibody biomarkers against a viral antigen; inflammatory and/or tissue damage response biomarkers; and/or extracellular vesicles in response to a viral infection.Type: ApplicationFiled: April 30, 2021Publication date: January 6, 2022Inventors: Jacob N. WOHLSTADTER, George SIGAL, Anu MATHEW, Anastasia AKSYUK, David ROUTENBERG, Martin STENGELIN, John KENTEN, Timothy J. BREAK, Seth B. HARKINS, Michael TSIONSKY
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Publication number: 20210190778Abstract: The present invention is directed to methods for improving assay specificity and performance in binding assays.Type: ApplicationFiled: December 23, 2020Publication date: June 24, 2021Inventors: Anahit AGHVANYAN, Eli N. GLEZER, John KENTEN, George SIGAL, Martin STENGELIN
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Publication number: 20210116452Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.Type: ApplicationFiled: May 26, 2020Publication date: April 22, 2021Applicant: Meso Scale Technologies, LLC.Inventors: Anahit Aghvanyan, Eli N. Glezer, John Kenten, Sudeep Kumar, Galina Nikolenko, Martin Stengelin, Srikant Vaithilingam
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Patent number: 10908157Abstract: The present disclosure is directed to a kit for the detection of an analyte of interest in a sample comprising, in one or more vials, containers, or compartments, a. a surface comprising (i) a capture reagent for the analyte, said capture reagent bound to the surface, and (ii) an anchoring reagent bound to an anchoring oligonucleotide sequence, said anchoring reagent bound to the surface, b. a first detection reagent for the analyte that is linked to a first nucleic acid probe, wherein the first nucleic acid probe comprises an extended sequence that is complementary to the anchoring oligonucleotide sequence and c. a second detection reagent for the analyte that is linked to a second nucleic acid probe.Type: GrantFiled: February 23, 2017Date of Patent: February 2, 2021Assignee: Meso Scale Technologies, LLC.Inventors: Anahit Aghvanyan, Eli N. Glezer, John Kenten, George Sigal, Martin Stengelin
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Publication number: 20200158731Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.Type: ApplicationFiled: January 21, 2020Publication date: May 21, 2020Applicant: Meso Scale Technologies, LLC.Inventors: Anahit Aghvanyan, Eli N. Glezer, John Kenten, Sudeep Kumar, Galina Nikolenko, Martin Stengelin
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Publication number: 20200057070Abstract: The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a chemotherapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.Type: ApplicationFiled: October 15, 2019Publication date: February 20, 2020Applicant: Meso Scale Technologies, LLC.Inventors: Eli N. Glezer, Anu Mathew, Martin Stengelin, Mingyue Wang
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Publication number: 20190391140Abstract: The present invention is directed to methods for improving assay specificity and performance in binding assays.Type: ApplicationFiled: September 9, 2019Publication date: December 26, 2019Applicant: MESO SCALE TECHNOLOGIES, LLC.Inventors: Anahit Aghvanyan, Eli N. Glezer, John Kenten, George Sigal, Martin Stengelin, David Routenberg
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Patent number: 10495643Abstract: The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a chemotherapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.Type: GrantFiled: October 19, 2016Date of Patent: December 3, 2019Assignee: MESO SCALE TECHNOLOGIES, LLC.Inventors: Eli N. Glezer, Anu Mathew, Martin Stengelin, Mingyue Wang
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Patent number: 10408823Abstract: The present invention is directed to methods for improving assay specificity and performance in binding assays.Type: GrantFiled: May 15, 2015Date of Patent: September 10, 2019Assignee: Meso Scale Technologies, LLC.Inventors: Anahit Aghvanyan, Eli N. Glezer, John Kenten, George Sigal, Martin Stengelin, David Routenberg
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Publication number: 20180074061Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.Type: ApplicationFiled: November 15, 2017Publication date: March 15, 2018Inventors: Anahit Aghvanyan, Eli N. Glezer, John Kenten, Sudeep Kumar, Galina Nikolenko, Martin Stengelin, Srikant Vaithilingam
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Publication number: 20170168047Abstract: The present disclosure is directed to a kit for the detection of an analyte of interest in a sample comprising, in one or more vials, containers, or compartments, a. a surface comprising (i) a capture reagent for the analyte, said capture reagent bound to the surface, and (ii) an anchoring reagent bound to an anchoring oligonucleotide sequence, said anchoring reagent bound to the surface, b. a first detection reagent for the analyte that is linked to a first nucleic acid probe, wherein the first nucleic acid probe comprises an extended sequence that is complementary to the anchoring oligonucleotide sequence and c. a second detection reagent for the analyte that is linked to a second nucleic acid probe.Type: ApplicationFiled: February 23, 2017Publication date: June 15, 2017Applicant: Meso Scale Technologies, LLC.Inventors: Anahit Aghvanyan, Eli N. Glezer, John Kenten, George Sigal, Martin Stengelin
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Publication number: 20170160281Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.Type: ApplicationFiled: February 23, 2017Publication date: June 8, 2017Applicant: Meso Scale Technologies, LLC.Inventors: Anahit Aghvanyan, Eli N. Glezer, John Kenten, Sudeep Kumar, Galina Nikolenko, Martin Stengelin
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Patent number: 9618510Abstract: The present disclosure is directed to a kit for the detection of an analyte of interest in a sample comprising, in one or more vials, containers, or compartments, a. a surface comprising (i) a capture reagent for the analyte, said capture reagent bound to the surface, and (ii) an anchoring reagent bound to an anchoring oligonucleotide sequence, said anchoring reagent bound to the surface, b. a first detection reagent for the analyte that is linked to a first nucleic acid probe, wherein the first nucleic acid probe comprises an extended sequence that is complementary to the anchoring oligonucleotide sequence and c. a second detection reagent for the analyte that is linked to a second nucleic acid probe.Type: GrantFiled: March 12, 2014Date of Patent: April 11, 2017Assignee: MESO SCALE TECHNOLOGIES, LLC.Inventors: Anahit Aghvanyan, Eli N. Glezer, John Kenten, George Sigal, Martin Stengelin
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Publication number: 20170089892Abstract: The present invention is directed to methods for improving assay specificity and performance in binding assays.Type: ApplicationFiled: May 15, 2015Publication date: March 30, 2017Applicant: MESO SCALE TECHNOLOGIES, LLC.Inventors: Anahit AGHVANYAN, Eli N. GLEZER, John KENTEN, George SIGAL, Martin STENGELIN, David ROUTENBERG