Abstract: A computer-implemented method and apparatus for assessing treatment adherence by patients, the method comprising: receiving a model providing statistical significance of patients' response to treatment, the model based on treatment assigned to the patients, wherein the patients are diagnosed with a disease; computing by the computerized device a p-value for a result received for a patient diagnosed with the disease and being treated by the treatment, by applying the model to at least one patient; and issuing an alert responsive to the p-value being indicative of the result being unexpected beyond a threshold.