Patents by Inventor Martin Stigter

Martin Stigter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Controlled release system
    Patent number: 10632131
    Abstract: The present invention relates to controlled release systems that may be administered other than intravenously. The controlled release system is directed to active ingredients, entrapped in or otherwise incorporated in or coupled to polymer carriers or polymeric devices, such as micelles, nanoparticles, microspheres and other types of polymer devices for controlled release; the active ingredients are covalently bonded to the polymer carriers or polymeric devices. The controlled release systems may suitably be used to treat diseases.
    Type: Grant
    Filed: June 26, 2012
    Date of Patent: April 28, 2020
    Assignee: CRISTAL DELIVERY B.V.
    Inventors: Cristianne Johanna Ferdinand Rijcken, Martin Stigter, Josephus Johannes Maria Holthuis
  • CONTROLLED RELEASE SYSTEM
    Publication number: 20140199244
    Abstract: The present invention relates to controlled release systems that may be administered other than intravenously. The controlled release system is directed to active ingredients, entrapped in or otherwise incorporated in or coupled to polymer carriers or polymeric devices, such as micelles, nanoparticles, microspheres and other types of polymer devices for controlled release; the active ingredients are covalently bonded to the polymer carriers or polymeric devices. The controlled release systems may suitably be used to treat diseases.
    Type: Application
    Filed: June 26, 2012
    Publication date: July 17, 2014
    Applicant: CRISTAL DELIVERY B.V.
    Inventors: Cristianne Johanna Ferdinand Rijcken, Martin Stigter, Josephus Johannes Maria Holthuis
  • Controlled release compositions for interferon based PEGT/PBT block copolymers and method for preparation thereof
    Patent number: 8163307
    Abstract: The invention discloses a pharmaceutical composition for the controlled release of relatively toxic active compounds, in particular for bioactive proteins from the class of interferons. The composition comprises a biodegradable block copolymer constructed from poly(ethylene glycol) terephthalate (PEGT) and poly(butylene terephthalate) (PBT). The composition is provided in the form of injectable microparticles, of an injectable liquid which may have self-gelling properties, or of a solid implant. The invention further provides a pharmaceutical kit comprising the composition, methods for preparing the composition, and the pharmaceutical uses relating thereto.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: April 24, 2012
    Assignee: Biolex Therapeutics, Inc.
    Inventors: Anne Chantal Bechet, Riemke Van Dijkhuizen-Radersma, Martin Stigter, Jeroen Mattijs Bezemer
  • Controlled release compositions for interferon based on PEGT/PBT block copolymers and method for preparation thereof
    Patent number: 7867518
    Abstract: The invention discloses a pharmaceutical composition for the controlled release of relatively toxic active compounds, in particular for bioactive proteins from the class of interferons. The composition comprises a biodegradable block copolymer constructed from poly(ethylene glycol) terephthalate (PEGT) and poly(butylene terephthalate) (PBT). The composition is provided in the form of injectable microparticles, of an injectable liquid which may have self-gelling properties, or of a solid implant. The invention further provides a pharmaceutical kit comprising the composition, methods for preparing the composition, and the pharmaceutical uses relating thereto.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: January 11, 2011
    Assignee: Biolex Therapeutics, Inc.
    Inventors: Anne Chantal Bechet, Riemke Van Dijkhuizen-Radersma, Martin Stigter, Jeroen Mattijs Bezemer
  • Controlled release compositions for interferon based on PEGT/PBT block copolymers
    Patent number: 7736674
    Abstract: The invention discloses a pharmaceutical composition for the controlled release of relatively toxic active compounds, in particular for bioactive proteins from the class of interferons. The composition comprises a biodegradable block copolymer constructed from poly(ethylene glycol) terephthalate (PEGT) and poly(butylene terephthalate) (PBT). The composition is provided in the form of injectable microparticles, of an injectable liquid which may have self-gelling properties, or of a solid implant. The invention further provides a pharmaceutical kit comprising the composition, methods for preparing the composition, and the pharmaceutical uses relating thereto.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: June 15, 2010
    Assignee: Biolex Therapeutics, Inc.
    Inventors: Anne Chantal Bechet, Riemke Van Dijkhuizen-Radersma, Martin Stigter, Jeroen Mattijs Bezemer
  • Controlled Release Compositions for Interferon Based on PEGT/PBT Block Copolymers
    Publication number: 20100074868
    Abstract: The invention discloses a pharmaceutical composition for the controlled release of relatively toxic active compounds, in particular for bioactive proteins from the class of interferons. The composition comprises a biodegradable block copolymer constructed from poly(ethylene glycol) terephthalate (PEGT) and poly(butylene terephthalate) (PBT). The composition is provided in the form of injectable microparticles, of an injectable liquid which may have self-gelling properties, or of a solid implant. The invention further provides a pharmaceutical kit comprising the composition, methods for preparing the composition, and the pharmaceutical uses relating thereto.
    Type: Application
    Filed: November 25, 2009
    Publication date: March 25, 2010
    Applicant: BIOLEX THERAPEUTICS, INC.
    Inventors: Anne Chantal BECHET, Riemke VAN DIJKHUIZEN-RADERSMA, Martin STIGTER, Jeroen Mattijs BEZEMER
  • Controlled Release Compositions for Interferon Based on PEGT/PBT Block Copolymers
    Publication number: 20090226532
    Abstract: The invention discloses a pharmaceutical composition for the controlled release of relatively toxic active compounds, in particular for bioactive proteins from the class of interferons. The composition comprises a biodegradable block copolymer constructed from poly(ethylene glycol) terephthalate (PEGT) and poly(butylene terephthalate) (PBT). The composition is provided in the form of injectable microparticles, of an injectable liquid which may have self-gelling properties, or of a solid implant. The invention further provides a pharmaceutical kit comprising the composition, methods for preparing the composition, and the pharmaceutical uses relating thereto.
    Type: Application
    Filed: May 15, 2009
    Publication date: September 10, 2009
    Applicant: BIOLEX THERAPEUTICS, INC.
    Inventors: Anne Chantal BECHET, Riemke VAN DIJKHUIZEN-RADERSMA, Martin STIGTER, Jeroen Mattijs BEZEMER
  • CONTROLLED RELEASE COMPOSITIONS FOR INTERFERON BASED ON PEGT/PBT BLOCK COPOLYMERS
    Publication number: 20080008733
    Abstract: The invention discloses a pharmaceutical composition for the controlled release of relatively toxic active compounds, in particular for bioactive proteins from the class of interferons. The composition comprises a biodegradable block copolymer constructed from poly(ethylene glycol) terephthalate (PEGT) and poly(butylene terephthalate) (PBT). The composition is provided in the form of injectable microparticles, of an injectable liquid which may have self-gelling properties, or of a solid implant. The invention further provides a pharmaceutical kit comprising the composition, methods for preparing the composition, and the pharmaceutical uses relating thereto.
    Type: Application
    Filed: July 6, 2007
    Publication date: January 10, 2008
    Applicant: OctoPlus Sciences B.V.
    Inventors: Anne Bechet, Riemke van Dijkhuizen-Radersma, Martin Stigter, Jeroen Bezemer
  • Method for applying a bioactive coating on a medical device
    Patent number: 6994883
    Abstract: The invention relates to the field of medical devices. More in particular, the invention relates to a method for coating by depositing inorganic ions and a bioactive agent to provide sterile medical devices, wherein said coating improves the biocompatibility and/or bioactivity of a medical device, such as an orthopedic or dental prosthesis. Furthermore, the invention relates to a medical device coated with a method according to the invention and to a reactor for use in a method according to the invention.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: February 7, 2006
    Assignee: IsoTis S.A.
    Inventors: Pierre Jean F. Layrolle, Martin Stigter, Klaas De Groot, Yuelian Liu
  • METHOD FOR APPLYING A BIOACTIVE COATING ON A MEDICAL DEVICE
    Publication number: 20050170070
    Abstract: The invention relates to the field of medical devices. More in particular, the invention relates to a method for coating by depositing inorganic ions and a bioactive agent to provide sterile medical devices, wherein said coating improves the biocompatibility and/or bioactivity of a medical device, such as an orthopedic or dental prosthesis. Furthermore, the invention relates to a medical device coated with a method according to the invention and to a reactor for use in a method according to the invention.
    Type: Application
    Filed: July 30, 2003
    Publication date: August 4, 2005
    Applicant: IsoTis S.A.
    Inventors: Pierre Layrolle, Martin Stigter, Klaas de Groot, Yuelian Liu