Patents by Inventor Martin Titz

Martin Titz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Real-time PCR elbow calling by equation-less algorithm
    Patent number: 8219324
    Abstract: Systems and methods for determining a transition value in a sigmoid or growth curve, such as the end of the baseline region or the elbow value or Ct value of a PCR amplification curve. Numerical determinations of the second derivatives and curvature values of a PCR data set are made. A Gaussian Mixture Model (GMM) function with parameters determined using a Levenberg-Marquardt (LM), or other, regression process is used to find an approximation to the second derivative values and to the curvature values, where the maximum values of the numerically determined second derivative values and/or curvature values are used as initial conditions for parameters of the GMM function. The determined parameters provide fractional Ct values. The Ct value(s) are then returned and may be displayed or otherwise used for further processing.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: July 10, 2012
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Ronald T. Kurnik, Martin Titz
  • Determination of elbow values for PCR for parabolic shaped curves
    Patent number: 8219366
    Abstract: Systems and methods for processing PCR curves, and for identifying the presence of a parabolic-shaped PCR curve. Use of a piecewise linear approximation of a PCR curve enables a more realistic elbow value to be determined in the case of parabolic shaped PCR curves.
    Type: Grant
    Filed: August 26, 2009
    Date of Patent: July 10, 2012
    Assignee: Roche Molecular Sytems, Inc.
    Inventors: Martin Titz, Ronald T. Kurnik
  • DETERMINATION OF ELBOW VALUES FOR PCR FOR PARABOLIC SHAPED CURVES
    Publication number: 20110054852
    Abstract: Systems and methods for processing PCR curves, and for identifying the presence of a parabolic-shaped PCR curve. Use of a piecewise linear approximation of a PCR curve enables a more realistic elbow value to be determined in the case of parabolic shaped PCR curves.
    Type: Application
    Filed: August 26, 2009
    Publication date: March 3, 2011
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Martin Titz, Ronald T. Kurnik
  • REAL-TIME PCR ELBOW CALLING BY EQUATION-LESS ALGORITHM
    Publication number: 20100070185
    Abstract: Systems and methods for determining a transition value in a sigmoid or growth curve, such as the end of the baseline region or the elbow value or Ct value of a PCR amplification curve. Numerical determinations of the second derivatives and curvature values of a PCR data set are made. A Gaussian Mixture Model (GMM) function with parameters determined using a Levenberg-Marquardt (LM), or other, regression process is used to find an approximation to the second derivative values and to the curvature values, where the maximum values of the numerically determined second derivative values and/or curvature values are used as initial conditions for parameters of the GMM function. The determined parameters provide fractional Ct values. The Ct value(s) are then returned and may be displayed or otherwise used for further processing.
    Type: Application
    Filed: September 12, 2008
    Publication date: March 18, 2010
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Ronald T. Kurnik, Martin Titz