Patents by Inventor Martin TOLAR

Martin TOLAR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sulfopropanoic acid derivatives for treating neurodegenerative disorders
    Patent number: 12285400
    Abstract: Provided herein is the use of a compound of Formula (I): or a pharmaceutically acceptable salt thereof, for treating a disease characterized by amyloid and amyloid-like aggregates, e.g., Alzheimer's disease.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: April 29, 2025
    Assignee: Alzheon, Inc.
    Inventors: Petr Kocis, John Hey, Martin Tolar
  • ALZ-801 FOR USE IN TREATING A COVID-19 ASSOCIATED NEUROLOGICAL SYMPTOM
    Publication number: 20250127734
    Abstract: Provided herein are methods for reducing p-tau, Abeta40, Abeta42, and/or the p-tau/Abeta+2 ratio in subjects using ALZ-801. Also provided are methods of treating conditions associated with elevated levels of p-tau, elevated levels of Abeta40, elevated levels of Abeta42, and/or an elevated p-tau/Abeta42 ratio.
    Type: Application
    Filed: February 7, 2023
    Publication date: April 24, 2025
    Inventors: Susan Abushakra, John Hey, Martin Tolar
  • ALZ-801 FOR USE IN TREATING ALZHEIMER'S DISEASE
    Publication number: 20250041248
    Abstract: Provided herein are methods for treating Alzheimer's disease using increased dosages amounts of ALZ-801.
    Type: Application
    Filed: December 9, 2022
    Publication date: February 6, 2025
    Inventors: Susan Abushakra, Neil William Flanzraich, John Hey, Martin Tolar
  • Compositions and methods for treating and preventing neurodegenerative disorders
    Patent number: 12187668
    Abstract: Compounds, pharmaceutical compositions, methods and kits are described for treating or preventing neurodegenerative diseases such as Alzheimer's disease.
    Type: Grant
    Filed: February 16, 2022
    Date of Patent: January 7, 2025
    Assignee: Alzheon, Inc.
    Inventors: Petr Kocis, Martin Tolar, John Hey
  • METHODS FOR TREATING NEURODEGENERATIVE DISORDERS
    Publication number: 20240325354
    Abstract: Methods of treating a disease characterized by amyloid aggregates are provided herein.
    Type: Application
    Filed: June 6, 2024
    Publication date: October 3, 2024
    Inventors: Petr Kocis, Martin Tolar, John Hey
  • Methods for treating neurodegenerative disorders
    Patent number: 12083082
    Abstract: Tramiprosate and derivatives thereof are provided herein for treating neurodegenerative disorders such as Alzheimer's disease (AD).
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: September 10, 2024
    Assignee: Alzheon, Inc.
    Inventors: John Hey, Petr Kocis, Martin Tolar, Neil William Flanzraich
  • Methods for treating neurodegenerative disorders
    Patent number: 12036208
    Abstract: Methods of treating a disease characterized by amyloid aggregates are provided herein.
    Type: Grant
    Filed: June 25, 2021
    Date of Patent: July 16, 2024
    Assignee: Alzheon, Inc.
    Inventors: Petr Kocis, Martin Tolar, John Hey
  • METHODS OF TREATING NEURODEGENERATIVE DISORDERS IN A PARTICULAR POPULATION
    Publication number: 20230414541
    Abstract: Disclosed herein are methods for treating, ameliorating, and/or preventing Alzheimer's Disease in a specific patient population using tramiprosate, valyl-3-amino-1-propanesulfonic acid, or a pharmaceutically acceptable salt thereof, based upon a combination of APOE4 status and disease severity.
    Type: Application
    Filed: September 6, 2023
    Publication date: December 28, 2023
    Inventors: Susan ABUSHAKRA, Aidan POWER, Martin TOLAR, John HEY, Jeremy YU, Petr KOCIS
  • COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING NEURODEGENERATIVE DISORDERS
    Publication number: 20230133465
    Abstract: Compounds, pharmaceutical compositions, methods and kits are described for treating or preventing neurodegenerative diseases such as Alzheimer's disease.
    Type: Application
    Filed: February 16, 2022
    Publication date: May 4, 2023
    Inventors: Petr Kocis, Martin Tolar, John Hey
  • METHODS FOR TREATING NEUROLOGICAL DISORDERS
    Publication number: 20230087041
    Abstract: Disclosed herein are methods and compositions for treating, ameliorating, and/or preventing Alzheimer's disease in ApoE4-postitive patients using particular compounds and compositions thereof.
    Type: Application
    Filed: July 29, 2022
    Publication date: March 23, 2023
    Inventors: Martin TOLAR, John A. HEY, Petr KOCIS, Jeremy YU
  • METHODS FOR TREATING NEURODEGENERATIVE DISORDERS
    Publication number: 20230024950
    Abstract: Provided herein are methods for using hippocampal volume and/or cortical thickness in human subjects as a predictor of Alzheimer's disease (AD) and treating subjects who are determined to be at risk for AD or a decline in cognitive impairment.
    Type: Application
    Filed: June 16, 2020
    Publication date: January 26, 2023
    Inventors: Susan Abushakra, John Hey, Aidan Power, Martin Tolar
  • METHODS OF TREATING NEURODEGENERATIVE DISORDERS IN A PARTICULAR POPULATION
    Publication number: 20220096406
    Abstract: Disclosed herein are methods for treating, ameliorating, and/or preventing Alzheimer's Disease in a specific patient population using tramiprosate, valyl-3-amino-1-propanesulfonic acid, or a pharmaceutically acceptable salt thereof based upon a combination of APOE4 status and disease severity.
    Type: Application
    Filed: September 17, 2021
    Publication date: March 31, 2022
    Inventors: Susan ABUSHAKRA, Aidan POWER, Martin TOLAR, John HEY, Jeremy YU, Petr KOCIS
  • SULFOPROPANOIC ACID DERIVATIVES FOR TREATING NEURODEGENERATIVE DISORDERS
    Publication number: 20220087967
    Abstract: Provided herein is the use of a compound of Formula (I) or a pharmaceutically acceptable salt thereof, for treating a disease characterized by amyloid and amyloid-like aggregates, e.g., Alzheimer's disease.
    Type: Application
    Filed: July 30, 2019
    Publication date: March 24, 2022
    Inventors: Petr Kocis, John Hey, Martin Tolar
  • METHODS FOR TREATING NEURODEGENERATIVE DISORDERS
    Publication number: 20220062241
    Abstract: Methods of treating a disease characterized by amyloid aggregates are provided herein.
    Type: Application
    Filed: June 25, 2021
    Publication date: March 3, 2022
    Inventors: Petr Kocis, Martin Tolar, John Hey
  • Methods of treating neurodegenerative disorders in a particular population
    Patent number: 11191742
    Abstract: Disclosed herein are methods for treating, ameliorating, and/or preventing Alzheimer's Disease in a specific patient population using tramiprosate, valyl-3-amino-1-propanesulfonic acid, or a pharmaceutically acceptable salt thereof based upon a combination of APOE4 status and disease severity.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: December 7, 2021
    Assignee: Alzheon, Inc.
    Inventors: Susan Abushakra, Aidan Power, Martin Tolar, John Hey, Jeremy Yu, Petr Kocis
  • METHODS FOR TREATING NEURODEGENERATIVE DISORDERS
    Publication number: 20210315847
    Abstract: Tramiprosate and derivatives thereof are provided herein for treating neurodegenerative disorders such as Alzheimer's disease (AD).
    Type: Application
    Filed: July 30, 2019
    Publication date: October 14, 2021
    Inventors: John Hey, Petr Kocis, Martin Tolar, Neil William Flanzraich
  • Methods for treating neurodegenerative disorders
    Patent number: 11077095
    Abstract: Methods of treating a disease characterized by amyloid aggregates are provided herein.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: August 3, 2021
    Assignee: Alzheon, Inc.
    Inventors: Petr Kocis, Martin Tolar, John Hey
  • Compositions and methods for treating and preventing neurodegenerative disorders
    Patent number: 11053192
    Abstract: Compounds, pharmaceutical compositions, methods and kits are described for treating or preventing neurodegenerative diseases such as Alzheimer's disease.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: July 6, 2021
    Assignee: Alzheon, Inc.
    Inventors: Petr Kocis, Martin Tolar, John Hey
  • COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING NEURODEGENERATIVE DISORDERS
    Publication number: 20200347012
    Abstract: Compounds, pharmaceutical compositions, methods and kits are described for treating or preventing neurodegenerative diseases such as Alzheimer's disease.
    Type: Application
    Filed: March 3, 2020
    Publication date: November 5, 2020
    Inventors: Petr Kocis, Martin Tolar, John Hey
  • METHODS FOR TREATING NEUROLOGICAL DISORDERS
    Publication number: 20200101031
    Abstract: Disclosed herein are methods and compositions for treating, ameliorating, and/or preventing Alzheimer's disease in ApoE4-postitive patients using particular compounds and compositions thereof.
    Type: Application
    Filed: September 13, 2019
    Publication date: April 2, 2020
    Inventors: Martin TOLAR, John A. HEY, Petr KOCIS, Jeremy YU