Abstract: A topical ophthalmic anesthetic composition includes a formulation with an amount of articaine to provide anesthetic properties when applied topically to the eye, and a pH, viscosity, osmolality, dissociation constant, and additives such as antioxidants, buffers, methylcellulose, to achieve efficacy and safety. The composition can contain articaine in amounts of about 4.0% w/v to about 12.0% w/v and have a pH of about pH 3.5 to pH 7.0. The buffer can be borate/mannitol complex obtained from boric acid or salt thereof and D-mannitol. The articaine formulations can achieve adequate anesthesia of the internal aspect of the eye wall by topical application, without the use of an injectable anesthetic. Exemplary implementations of the disclosure include formulations include articaine in an amount of at least 7.0% w/v, where the formulation is an aqueous solution, a gel, an ointment, or in an encapsulated form.

Abstract: A topical ophthalmic anesthetic composition includes a formulation with an amount of articaine to provide anesthetic properties when applied topically to the eye, and a pH, viscosity, osmolality, dissociation constant, and additives such as antioxidants, buffers, methylcellulose, to achieve efficacy and safety. The composition can contain articaine in amounts of about 4.0% w/v to about 12.0% w/v and have a pH of about pH 3.5 to pH 7.0. The buffer can be borate/mannitol complex obtained from boric acid or salt thereof and D-mannitol. The articaine formulations can achieve adequate anesthesia of the internal aspect of the eye wall by topical application, without the use of an injectable anesthetic. Exemplary implementations of the disclosure include formulations include articaine in an amount of at least 7.0% w/v, where the formulation is an aqueous solution, a gel, an ointment, or in an encapsulated form.

Abstract: Systems and methods for intelligently delivering fluid to a targeted tissue are described. The systems and methods may include directing a pump to distribute fluid to a targeted tissue and receiving one or more signals from an intracorporeal sensing system, where the one or more signals correspond to one or more sensed feedback parameters at the targeted tissue. The systems and methods may also include determining whether the one or more sensed feedback parameters are within an acceptable range.

Abstract: Systems and methods for intelligently delivering fluid to a targeted tissue are described. The systems and methods may include directing a pump to distribute fluid to a targeted tissue and receiving one or more signals from an intracorporeal sensing system, where the one or more signals correspond to one or more sensed feedback parameters at the targeted tissue. The systems and methods may also include determining whether the one or more sensed feedback parameters are within an acceptable range. If the one or more sensed feedback parameters are not within the acceptable range, the systems and methods may include determining an adjusted velocity for the plunger necessary to adjust the pressure of the fluid in the pump so that the one or more sensed feedback parameters move within the acceptable range and directing the pump to distribute the fluid at the adjusted velocity.

Abstract: Laser video endoscope has laser guide, illumination guide and image guide which extend through optical probe and through hand piece that supports the probe. Hand piece is connected by optical fiber cable to laser energy source and illumination source. Image is transmitted from hand piece to image processing interface by camera assembly optically coupled and mounted directly to hand piece and via electrical cable extending from camera assembly. Camera and its electrical cable can be uncoupled from hand piece and reused. The rest of the product, including probe and hand piece, can be disposed of after each medical routine. Probe can have proximal portion and distal portion such that proximal portion extends from distal end of hand piece, and outside diameter of proximal portion as measured at least near the distal end of hand piece is greater than the outside diameter of the distal portion.

Abstract: A topical ophthalmic anesthetic composition includes a formulation with an amount of articaine to provide anesthetic properties when applied topically to the eye, and a pH, viscosity, osmolality, dissociation constant, and additives such as antioxidants, buffers, methylcellulose, to achieve efficacy and safety. The composition can contain articaine in amounts of about 4.0% w/v to about 12.0% w/v and have a pH of about pH 3.5 to pH 7.0. The buffer can be borate/mannitol complex obtained from boric acid or salt thereof and D-mannitol. The articaine formulations can achieve adequate anesthesia of the internal aspect of the eye wall by topical application, without the use of an injectable anesthetic. Exemplary implementations of the disclosure include formulations include articaine in an amount of at least 7.0% w/v, where the formulation is an aqueous solution, a gel, an ointment, or in an encapsulated form.

Abstract: A topical ophthalmic anesthetic composition includes a formulation with an amount of articaine to provide anesthetic properties when applied topically to the eye, and a pH, viscosity, osmolality, dissociation constant, and additives such as antioxidants, buffers, methylcellulose, to achieve efficacy and safety. The composition can contain articaine in amounts of about 4.0% w/v to about 12.0% w/v and have a pH of about pH 3.5 to pH 7.0. The buffer can be borate/mannitol complex obtained from boric acid or salt thereof and D-mannitol. The articaine formulations can achieve adequate anesthesia of the internal aspect of the eye wall by topical application, without the use of an injectable anesthetic. Exemplary implementations of the disclosure include formulations include articaine in an amount of at least 7.0% w/v, where the formulation is an aqueous solution, a gel, an ointment, or in an encapsulated form.

Abstract: Electronic laser video endoscope comprising laser output, illumination output and imaging component disposed at a distal end of a probe, or a cannula, of the endoscope to facilitate precise illumination, targeted laser energy delivery, and accurate imaging at the site of a procedure, where the imaging component comprises an electronic image detection module. The electronic image detection module comprises an image sensor, such as CMOS (complementary metal-oxide semiconductor) and/or CCD (charge-coupled device) image sensor, disposed at a distal end of the probe.

Abstract: A topical ophthalmic anesthetic composition includes a formulation with an amount of articaine to provide anesthetic properties when applied topically to the eye, and a pH, viscosity, osmolality, dissociation constant, and additives such as antioxidants, buffers, methylcellulose, to achieve efficacy and safety. The composition can contain articaine in amounts of about 4.0% w/v to about 12.0% w/v and have a pH of about pH 3.5 to pH 7.0. The buffer can be borate/mannitol complex obtained from boric acid or salt thereof and D-mannitol. The articaine formulations can achieve adequate anesthesia of the internal aspect of the eye wall by topical application, without the use of an injectable anesthetic. Exemplary implementations of the disclosure include formulations include articaine in an amount of at least 7.0% w/v, where the formulation is an aqueous solution, a gel, an ointment, or in an encapsulated form.

Abstract: Systems and methods for intelligently delivering fluid to a targeted tissue are described. The systems and methods may include directing a pump to distribute fluid to a targeted tissue and receiving one or more signals from an intracorporeal sensing system, where the one or more signals correspond to one or more sensed feedback parameters at the targeted tissue. The systems and methods may also include determining whether the one or more sensed feedback parameters are within an acceptable range.

Abstract: Laser video endoscope has laser guide, illumination guide and image guide which extend through optical probe and through hand piece that supports the probe. Hand piece is connected by optical fiber cable to laser energy source and illumination source. Image is transmitted from hand piece to image processing interface by camera assembly optically coupled and mounted directly to hand piece and via electrical cable extending from camera assembly. Camera and its electrical cable can be uncoupled from hand piece and reused. The rest of the product, including probe and hand piece, can be disposed of after each medical routine. Probe can have proximal portion and distal portion such that proximal portion extends from distal end of hand piece, and outside diameter of proximal portion as measured at least near the distal end of hand piece is greater than the outside diameter of the distal portion.

Abstract: A laser video endoscope has a laser guide, an illumination guide and an image guide. These are fiber optical guides which extend through the optical probe and through a hand piece that supports the probe. The hand piece is connected by a first relatively long flexible optical fiber cable to a laser energy source and a source of illumination. By contrast, the image is transmitted from the hand piece to an image presentation site by a camera assembly that is mounted to the hand piece and a relatively long electrical cable. The camera and its electrical cable can be uncoupled from the hand piece and used in a plurality of endoscopic routines. The rest of the product, including the probe and the hand piece, can be disposed of after each medical routine thereby providing assurance of an antiseptic procedure.

Abstract: Laser video endoscope has laser guide, illumination guide and image guide which extend through optical probe and through hand piece that supports the probe. Hand piece is connected by optical fiber cable to laser energy source and illumination source. Image is transmitted from hand piece to image processing interface by camera assembly optically coupled and mounted directly to hand piece and via electrical cable extending from camera assembly. Camera and its electrical cable can be uncoupled from hand piece and reused. The rest of the product, including probe and hand piece, can be disposed of after each medical routine. Probe can have proximal portion and distal portion such that proximal portion extends from distal end of hand piece, and outside diameter of proximal portion as measured at least near the distal end of hand piece is greater than the outside diameter of the distal portion.

Abstract: A laser video endoscope provides a small diameter (25 mils) probe. This size probe requires a minimum access lesion. The tradeoff that produces such a probe includes reducing the laser guide fiber to 100 microns in diameter, employing an image bundle having approximately 6,000 optical fibers and an illumination bundle having only about 210 optical fibers. The probe where it extends into the handle has a 45 mil outer diameter and a 5 mil thick sidewall to provide resistance to breaking at the juncture with the handle. The probe is rigid, preferably metal. The probe has a larger diameter proximal portion and a smaller diameter distal portion. The distal portion of the probe has a length limited to about 710 mils. A green laser of 532 nanometers wavelength provides a collimated laser beam that causes minimal loss in the 100 micron laser optical fiber.

Abstract: A laser video endoscope has a laser guide, an illumination guide and an image guide. These are fiber optical guides which extend through the optical probe and through a hand piece that supports the probe. The hand piece is connected by a first relatively long flexible optical fiber cable to a laser energy source and a source of illumination. By contrast, the image is transmitted from the hand piece to an image presentation site by a camera assembly that is mounted to the hand piece and a relatively long electrical cable. The camera and its electrical cable can be uncoupled from the hand piece and used in a plurality of endoscopic routines. The rest of the product, including the probe and the hand piece, can be disposed of after each medical routine thereby providing assurance of an antiseptic procedure.

Abstract: A laser video endoscope has a laser guide, an illumination guide and an image guide. These are fiber optical guides which extend through the optical probe and through a hand piece that supports the probe. The hand piece is connected by a first relatively long flexible optical fiber cable to a laser energy source and a source of illumination. By contrast, the image is transmitted from the hand piece to an image presentation site by a camera assembly that is mounted to a hand piece and a relatively long electrical cable. The camera and its electrical cable can be uncoupled from the hand piece and used in a plurality of endoscopic routines. The rest of the product, including the probe and the hand piece, can be disposed of after each medical routine thereby providing assurance of an antiseptic procedure.

Abstract: An injector system for use in injecting a fluid into a patient includes a communication system adapted to receive data from at least a first sensor that measures a value first variable. The communication system is also adapted to receive data from a calibrated sensor that measures a value the first variable. The injector system further includes a calibration system adapted to calibrate output from the first sensor in response to output from the calibrated sensor. An injector for use in injecting a fluid into a patient, includes a first sensor that measures a value first variable, a communication port adapted to receive data from a calibrated sensor that measures the value the first variable, and a controller adapted to compare data from the calibrated sensor with data from the first sensor and to calibrate output from the first sensor. The devices, systems and methods of the present invention are applicable to systems other than injection systems.

Abstract: An injector system for use in injecting a fluid into a patient includes a communication system adapted to receive data from at least a first sensor that measures a value first variable. The communication system is also adapted to receive data from a calibrated sensor that measures a value the first variable. The injector system further includes a calibration system adapted to calibrate output from the first sensor in response to output from the calibrated sensor. An injector for use in injecting a fluid into a patient, includes a first sensor that measures a value first variable, a communication port adapted to receive data from a calibrated sensor that measures the value the first variable, and a controller adapted to compare data from the calibrated sensor with data from the first sensor and to calibrate output from the first sensor. The devices, systems and methods of the present invention are applicable to systems other than injection systems.

Abstract: An autoclavable endoscope, such as the type used in ophthalmological operations, has a probe that contains optical fiber guides such as an image guide, a laser guide and an illumination guide. The distal end of these guides are sealed to the distal end of the probe with a high temperature medical grade epoxy. The epoxy is selected to retain its structural and optical properties at autoclaving conditions. A preshrunk flexible plastic jacket extends proximal of the handle around the three guides. Because it is preshrunk at autoclavable temperatures, it is not further damaged during autoclaving. The epoxies used proximal to the probe have to be high temperature epoxies but are generally preferably a more flexible urethane type epoxy. Proximal connectors and ferule for the guides are selected metals to retain size and/or conduct heat.

Abstract: An autoclavable endoscope, such as the type used in ophthalmological operations, has a probe that contains optical fiber guides such as an image guide, a laser guide and an illumination guide. The distal end of these guides are sealed to the distal end of the probe with a high temperature medical grade epoxy. The epoxy is selected to retain its structural and optical properties at autoclaving conditions. A preshrunk flexible plastic jacket extends proximal of the handle around the three guides. Because it is preshrunk at autoclavable temperatures, it is not further damaged during autoclaving. The epoxies used proximal to the probe have to be high temperature epoxies but are generally preferably a more flexible urethane type epoxy. Proximal connectors and ferule for the guides are selected metals to retain size and/or conduct heat.