Abstract: The present invention provides multi-armed high MW polymers containing hydrophilic groups conjugated to Factor VIII, and methods of preparing such polymers.

Abstract: The disclosed exemplary embodiments include computer-implemented systems, apparatuses, and processes that dynamically manage consent, permissioning, and trust between computing systems and unrelated, third-party applications operating within a computing environment. By way of example, the apparatus may receive a request for an element of data that includes an access token and first credential data associated with an application program. When the first credential data corresponds to second credential data associated with the application program, may determine that the requested data element is accessible to the application program and perform operations that validate the access token. Further, and based on the validation of the access token, that apparatus may obtain and encrypt the requested data element, and may transmit the encrypted data element to a device via the communications interface.

Abstract: A retrofittable remote control system is provided for enabling remote controlling of an on-board component of machine that is inherently incapable of being remote controlled. An interface control module is retrofitted on machine and is configured to communicate with off-board remote control over wireless communication channel. The interface control module detects presence of an on-board control module that communicates with the on-board component over a digital communication channel. The interface control module is configured to then establish either a digital communication link with the on-board control module or a direct Input/Output (I/O) communication link with the on-board component of the machine based on the detection. The interface control module is configured to send a control signal over either the direct I/O communication link or the digital communication channel via the detected on-board control module, for controlling the on-board component.

Abstract: A biopsy device includes a cutting cannula mechanism having a cutting cannula and an inner stylet mechanism having an inner stylet coaxial with the cutting cannula. A cocking mechanism is configured to cock the cutting cannula mechanism and the inner stylet mechanism by retracting each of the cutting cannula and the inner stylet in a proximal direction to a cocked position. A trigger device is configured to fire at least one of the inner stylet mechanism and the cutting cannula mechanism to advance a respective at least one of the inner stylet and the cutting cannula from the cocked position in a distal direction. A selector assembly includes a selector switch having an exterior tab accessible by a user. The selector assembly is configured to select between at least two user selectable operating modes and at least two user selectable firing distances.

Abstract: A retrofittable remote control system is provided for enabling remote controlling of an on-board component of machine that is inherently incapable of being remote controlled. An interface control module is retrofitted on machine and is configured to communicate with off-board remote control over wireless communication channel. The interface control module detects presence of an on-board control module that communicates with the on-board component over a digital communication channel. The interface control module is configured to then establish either a digital communication link with the on-board control module or a direct Input/Output (I/O) communication link with the on-board component of the machine based on the detection. The interface control module is configured to send a control signal over either the direct I/O communication link or the digital communication channel via the detected on-board control module, for controlling the on-board component.

Abstract: A biopsy device includes a cutting cannula mechanism having a cutting cannula and an inner stylet mechanism having an inner stylet coaxial with the cutting cannula. A cocking mechanism is configured to cock the cutting cannula mechanism and the inner stylet mechanism by retracting each of the cutting cannula and the inner stylet in a proximal direction to a cocked position. A trigger device is configured to fire at least one of the inner stylet mechanism and the cutting cannula mechanism to advance a respective at least one of the inner stylet and the cutting cannula from the cocked position in a distal direction. A selector assembly includes a selector switch having an exterior tab accessible by a user. The selector assembly is configured to select between at least two user selectable operating modes and at least two user selectable firing distances.

Abstract: A biopsy device includes a cutting cannula mechanism having a cutting cannula and an inner stylet mechanism having an inner stylet coaxial with the cutting cannula. A cocking mechanism is configured to cock the cutting cannula mechanism and the inner stylet mechanism by retracting each of the cutting cannula and the inner stylet in a proximal direction to a cocked position. A trigger device is configured to fire at least one of the inner stylet mechanism and the cutting cannula mechanism to advance a respective at least one of the inner stylet and the cutting cannula from the cocked position in a distal direction. A selector assembly includes a selector switch having an exterior tab accessible by a user. The selector assembly is configured to select between at least two user selectable operating modes and at least two user selectable firing distances.

Abstract: A biopsy device includes a cutting cannula mechanism having a cutting cannula and an inner stylet mechanism having an inner stylet coaxial with the cutting cannula. A cocking mechanism is configured to cock the cutting cannula mechanism and the inner stylet mechanism by retracting each of the cutting cannula and the inner stylet in a proximal direction to a cocked position. A trigger device is configured to fire at least one of the inner stylet mechanism and the cutting cannula mechanism to advance a respective at least one of the inner stylet and the cutting cannula from the cocked position in a distal direction. A selector assembly includes a selector switch having an exterior tab accessible by a user. The selector assembly is configured to select between at least two user selectable operating modes and at least two user selectable firing distances.

Abstract: A biopsy device includes a cutting cannula mechanism having a cutting cannula and an inner stylet mechanism having an inner stylet coaxial with the cutting cannula. A cocking mechanism is configured to cock the cutting cannula mechanism and the inner stylet mechanism by retracting each of the cutting cannula and the inner stylet in a proximal direction to a cocked position. A trigger device is configured to fire at least one of the inner stylet mechanism and the cutting cannula mechanism to advance a respective at least one of the inner stylet and the cutting cannula from the cocked position in a distal direction. A selector assembly includes a selector switch having an exterior tab accessible by a user. The selector assembly is configured to select between at least two user selectable operating modes and at least two user selectable firing distances.

Abstract: A toner adder roll according to one example embodiment includes an electrically conductive shaft defining an axis of rotation of the toner adder roll. A foam member is cylindrically disposed about the shaft and forms an outer circumferential surface of the toner adder roll. The foam member is composed of a polymeric open-cell foam material. An abrasive agent is dispersed on the outer circumferential surface of the toner adder roll.

Abstract: A biopsy device includes a cutting cannula mechanism having a cutting cannula and an inner stylet mechanism having an inner stylet coaxial with the cutting cannula. A cocking mechanism is configured to cock the cutting cannula mechanism and the inner stylet mechanism by retracting each of the cutting cannula and the inner stylet in a proximal direction to a cocked position. A trigger device is configured to fire at least one of the inner stylet mechanism and the cutting cannula mechanism to advance a respective at least one of the inner stylet and the cutting cannula from the cocked position in a distal direction. A selector assembly includes a selector switch having an exterior tab accessible by a user. The selector assembly is configured to select between at least two user selectable operating modes and at least two user selectable firing distances.

Abstract: A toner release coating may be applied to a toner regulating member such as a doctor blade. The toner release coating may reduce toner adhesion at a doctoring pre-nip location of the doctor blade. The toner release coating may be formed from a mixture of lubricating particulate and polymeric binder resin in a liquid carrier.

Abstract: The present disclosure relates to a surface energy reduction material in the form of a topcoat or additive to a coating that may be applied to a toner regulating member such as a doctor blade which may reduce toner build-up about a nip region, pre-nip region, and/or post-nip region. The surface energy reduction material may be include any material having a surface energy of less than or equal to 35 dynes/cm, for example, between 15-30 dynes/cm, including all values and ranges therein. The surface energy reducing materials may include any material that provides a 25% or more reduction of the surface energy of the doctor blade compared to an untreated doctor blade, for example, greater than or equal to 50% reduction or greater than or equal to 75% reduction, including all values and ranges therein.

Abstract: The present invention provides an attachment or extension for pipettes and pipette tips. The attachment comprises separation materials which are preferably suitable for isolating nucleic acids from liquids. The separation materials are present in the form of a filter disc in a holder which only slightly increases the pipette volume and thus generates little dead volume.

Abstract: The present disclosure relates to a toner release coating that may be applied to a toner regulating member such as a doctor blade which may reduce toner adhesion at a doctoring pre-nip location. The toner release coating may be formed from lubricating particulate and a polymeric binder resin.

Abstract: The present disclosure relates to a surface energy reduction material in the form of a topcoat or additive to a coating that may be applied to a toner regulating member such as a doctor blade which may reduce toner build-up about a nip region, pre-nip region, and/or post-nip region. The surface energy reduction material may be include any material having a surface energy of less than or equal to 35 dynes/cm, for example, between 15-30 dynes/cm, including all values and ranges therein. The surface energy reducing materials may include any material that provides a 25% or more reduction of the surface energy of the doctor blade compared to an untreated doctor blade, for example, greater than or equal to 50% reduction or greater than or equal to 75% reduction, including all values and ranges therein.

Abstract: A doctor blade for use with an imaging apparatus includes an elongated member, and a metering surface formed on a portion of the elongated member. The metering surface has surface features, which are modified by buffing the metering surface.

Abstract: Methods and apparatus for increasing the bias force between a developer half and a cleaner half of a process cartridge are disclosed. One or more springs are interposed between the cleaner half and the developer half of the process cartridge. These springs are of sufficient strength to maintain a constant separation between the developer and the photosensitive member of the process cartridge. Sources of force other than springs, such as weights or elastic members may also be employed to provide and increase the bias force urging the developer and photosensitive member together.

Abstract: A pharmaceutical compound of the formula in which R1 and R2 are each hydrogen, halo, cyano or methyl, the dotted line represents an optional double bond, where R4 and R5 are each hydrogen, C1-6 alkyl, cyclopropyl or cyclopropyl-C1-6 alkyl, n is 0 or 1, and R3 is —SR6, —SOR6, —SO2R6, —COR6, —CH2OH or —CONHR7, where R6 is C1-6 alkyl and R7 is hydrogen or C1-6 alkyl; provided that when one of R1 and R2 is hydrogen and the other is fluoro, R4 and R5 are each hydrogen or C1-6 alkyl, and n is 0, then R3 is not —COR6 or —CONHR7; and salts thereof.