Abstract: A device for providing an output fluid at a regulated output pressure includes a pressure control unit controlled via a pilot control pressure and a pilot control unit that provides the pilot control pressure. The pressure control unit includes an inlet chamber for an input fluid having an input pressure, an outlet chamber for the output fluid having the regulated output pressure and a first valve unit that acts between the inlet chamber and the outlet chamber. A first diaphragm of the pressure control unit is acted upon by the pilot control pressure. A second diaphragm, which is mechanically coupled to the first diaphragm is acted upon by the output fluid having the output pressure acts. At least the second diaphragm mechanically acts on the first valve unit.

Abstract: The present invention relates to a capsule-weighing device (1) comprising a capsule holder (2) for receiving at least one capsule lower part (4), preferably for medical preparations, a weighing unit (5) that can be positioned independently of the capsule holder (2) and that has at least one first electrode (8) for weighing the capsule lower part (4) in the capsule holder (2), a transport device (3) for moving the capsule holder (2), independently of the weighing unit (5), to different stations (S1-S12), and at least one second electrode (9), wherein an outer wall (7) of the at least one capsule lower part (4) is exposed in the capsule holder (2), or is only thinly enclosed by the capsule holder (2), such that, by means of an electric field between the first and second electrodes (8, 9), the capsule lower part (4) can be weighed without moving the capsule lower part (4) in the capsule holder (2).

Abstract: The invention relates to a device (10; 10a;10b; 10c; 50) for checking pharmaceutical products (1), in particular hard gelatin capsules, by means of at least one radiation source (30; 60) preferably embodied as an X-ray source, and a conveying device which conveys the products (1) in a clocked manner in a radiation area (31) of the radiation source (30; 60). The radiation emitted by the radiation source (30; 60) penetrating the products (1) preferably perpendicular to the longitudinal axes thereof (2), and the radiation is captured on the side of the products (1) opposite the radiation source (30) by means of at least one sensor element (35) which is coupled to an evaluation device (36). The invention is characterized in that the conveyor device is embodied as a conveyor wheel (15; 15a; 51) which can rotate in a stepped manner about an axis (12; 52), and the products (1) are arranged, while being conveyed in the radiation area (31), in receiving areas (28; 37; 56) of the conveyor wheel (15; 5a; 51).

Abstract: A device for regulating the flow of a fluid is provided with a valve housing having at least two valve connections, which are fluidically connected to one another via a valve chamber, at least one valve seat, which has a fluid connection to the valve chamber and one of the valve connections, a valve element, which has an actuating section located outside of the valve chamber and a closing body located within the valve chamber for the at least one valve seat. An electromagnet having a solenoid armature acts upon the actuating section. The solenoid armature is supported via two flat springs.

Abstract: A device for controlling the flow of a liquid or gaseous medium, has at least one flow opening for the medium, and a movable valve element for controlling the flow opening. At least one damping body, which is preferably viscoelastic and acts on the valve element, is provided for obtaining a large dynamic range of the device in order to control flow in a fine, precise, and oscillation-free manner across a broad range of flow volume.

Abstract: A facet mirror device includes a facet element, a support device and a clamping device. The facet element includes a first support section, while the support device comprises a second support section contacting the first support section to support the facet element. The clamping device includes a tensioning element, a first end of the tensioning element being connected to the facet element a second end of the tensioning element being connected to a counter unit. The counter unit includes a third support section, the support device including a fourth support section contacting the third support section to support the counter unit.

Abstract: An electrical sleeve heater for heating an elongated part has a metallic and tubular casing extending coaxially along an axis with the part and surrounding the part. The casing has a front end is with a radially inwardly open cutout. A electrical heating element set in the casing is energizeable to heat the casing and the part surrounded by the casing. A thermocouple has a sensing tip in the cutout. A retaining body of at most low thermal conductivity is fitted in the cutout, holds the tip out of contact with the metallic casing, and urges the tip radially inward into direct engagement with an outer surface of the part. The retaining body is a molded part, a plate, or a spring of a material with low or negligible thermal conductivity.

Abstract: The invention relates to a device (10; 10a;10b; 10c; 50) for checking pharmaceutical products (1), in particular hard gelatin capsules, by means of at least one radiation source (30; 60) preferably embodied as an X-ray source, and a conveying device which conveys the products (1) in a clocked manner in a radiation area (31) of the radiation source (30; 60). The radiation emitted by the radiation source (30; 60) penetrating the products (1) preferably perpendicular to the longitudinal axes thereof (2), and the radiation is captured on the side of the products (1) opposite the radiation source (30) by means of at least one sensor element (35) which is coupled to an evaluation device (36). The invention is characterised in that the conveyor device is embodied as a conveyor wheel (15; 15a; 51) which can rotate in a stepped manner about an axis (12; 52), and the products (1) are arranged, whilst being conveyed in the radiation area (31), in receiving areas (28; 37; 56) of the conveyor wheel (15; 5a; 51).

Abstract: The invention relates to a control device (10) comprising a radiation source (17) which is embodied, in particular, as an X-ray source for irradiating a pharmaceutical product (1) embodied, in particular as a capsule, a detector (18) for detecting radiation after irradiating the pharmaceutical product (1), a tube or shaft-shaped supply device (15) which is preferably arranged vertically at least in the region of the beam path (16) of the radiation source (17) for feeding the pharmaceutical product (1) into the beam path (16) of the radiation source (17), and means (25) for positioning and releasing the pharmaceutical product (1) in the region of the radiation beam (16) of the radiation source (17).

Abstract: The invention relates to a device (10; 10a) for controlling pharmaceutical products (1) in particular, hard gelatin capsules, by means of a radiation source (11) preferably designed as an X-ray source, comprising a storage device (13) which receives the products (1) in an uncontrolled manner, and from which the products (1) are transferred to a transport element (15) in which the products (1) are arranged such that they form at least one row. The products (1) are transported in a clocked manner in the radiation area (25) of the radiation source (11) which exposes the products (1) to radiation, preferably perpendicular to the longitudinal direction thereof. A first stopping device (20) for separating the products (1) in the row is arranged upstream of the radiation source (11) in the direction of transportation (18) of the products (1), and at least one sensor element (28, 28a) coupled to an evaluation device (30) captures the radiation which passed through the products (1).

Abstract: Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic benzophenone derivative of formula (1), selected from the crystal modifications (B) and (C), wherein the crystal modification (B) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.70; and wherein the crystal modification (C) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.06; and (b) a dispersing agent selected from anionic, non-ionic and amphoteric surfactants; for protecting the human skin from browning and skin aging. The new crystal modification (C) represents a thermodynamically stable compound of formula (1) at 25° C. This modification is therefore suitable in dispersions comprising micro-fine particles.

Abstract: The invention relates to a device (10; 10a) for determining the weight of pharmaceutical products (1), in particular of hard gelatin capsules (3; 3a) filled with a pharmaceutical (2), by means of an X-ray source (28), wherein the X-ray source (28) generates a radiation cone (27; 36, 37) which passes through at least one pharmaceutical product (1), and wherein a sensor element (30; 30a) detects the radiation of the irradiated pharmaceutical product (1) and supplies an evaluation device (32).

Abstract: The invention relates to a sensor device (30; 30a; 30b; 30c) for a packaging machine (100) designed as a capsule filling and sealing machine or for a capsule control device (100a), said device having a positioning element (35; 35a) for positioning a container (c) having a longitudinal axis (15) and filled with a filling material in the region of the sensor device (30; 30a; 30b; 30c) and at least one radiation source (31; 31 a; 3 b) and at least one detector (40; 40a; 40b) for detecting the radiation after said radiation radiates through the container (c). According to the invention, the at least one radiation source (31; 31a; 31b) radiates through the container (c) perpendicular to the longitudinal axis (15) thereof and the positioning element is designed as a tubular or shaft-shaped conveying element (35; 35a) which can be penetrated by the radiation in a radiation cone (38) of the radiation source (31; 31a; 31b).

Abstract: An electrical sleeve heater for heating an elongated part has a metallic and tubular casing extending coaxially along an axis with the part and surrounding the part. The casing has a front end is with a radially inwardly open cutout. A electrical heating element set in the casing is energizeable to heat the casing and the part surrounded by the casing. A thermocouple has a sensing tip in the cutout. A retaining body of at most low thermal conductivity is fitted in the cutout, holds the tip out of contact with the metallic casing, and urges the tip radially inward into direct engagement with an outer surface of the part. The retaining body is a molded part, a plate, or a spring of a material with low or negligible thermal conductivity.

Abstract: Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic compound which has a UV-Vis spectrum with a maximum from 380 to 420 nm; and (b) an anionic dispersing agent for protecting the human skin from browning and skin aging.

Abstract: A device for controlling the flow of a liquid or gaseous medium, has at least one flow opening for the medium, and a movable valve element for controlling the flow opening. At least one damping body, which is preferably viscoelastic and acts on the valve element, is provided for obtaining a large dynamic range of the device in order to control flow in a fine, precise, and oscillation-free manner across a broad range of flow volume.

Abstract: Disclosed is a process for the preparation of a mixture of 4-bromophenyl derivatives (compound of formula (2)) and 2,4-dibromophenyl derivatives (compound of formula (3)) comprising the steps of [1] reacting in a two-phase (liquid-liquid) system a bromide containing source with a phenyl derivative (formula (1)) in the presence of an excess of an oxidizing agent, an acid, and optionally a catalyst selected from vanadium pentoxide and ammonium heptamolybdate forming 4-bromo- (compound of formula (2)) and 2,4-dibromo derivatives (compound of formula (3)) and as intermediate product the 2-bromo derivative (compound of formula (4)) which reacts in step [2] to the 2,4-dibromo derivative (formula (3)) according to the following reaction scheme 2 wherein R1 is hydroxy; C1-C5alkoxy; or —NR2R3; and R2 and R3 independently from each other are hydrogen; or C1-C5alkyl.

Abstract: The present invention provides thrombospondin, thyroglobulin and trfoil/PD monomer domains and multimers comprising the monomer domains are provided. Methods, compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.

Abstract: Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic benzophenone derivative of formula (1), selected from the crystal modifications (B) and (C), wherein the crystal modification (B) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.70; and wherein the crystal modification (C) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.06; and (b) a dispersing agent selected from anionic, non-ionic and amphoteric surfactants; for protecting the human skin from browning and skin aging. The new crystal modification (C) represents a thermodynamically stable compound of formula (1) at 25° C. This modification is therefore suitable in dispersions comprising micro-fine particles.

Abstract: Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic compound which has a UV-Vis spectrum with a maximum from 380 to 420 nm; and (b) an anionic dispersing agent for protecting the human skin from browning and skin aging.