Patents by Inventor Martin W. Brechbiel

Martin W. Brechbiel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same
    Publication number: 20030228262
    Abstract: Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging and treatment of a cellular disorder.
    Type: Application
    Filed: December 13, 2002
    Publication date: December 11, 2003
    Applicants: The Government of the United States of America, represented by the Secretary Department of Health, and Human Services
    Inventors: Martin W. Brechbiel, Hyun-Soon Chong
  • Cytotoxic metal chelators and methods for making and using same
    Patent number: 6589966
    Abstract: A family of hexadentate Fe(II) chelators having marked antiproliferative activity against tumor cells is disclosed.
    Type: Grant
    Filed: September 18, 2000
    Date of Patent: July 8, 2003
    Assignees: Wake Forest University Health Sciences, University of New Hampshile, National Institutes of Health
    Inventors: Suzy V. Torti, Frank M. Torti, Roy P. Planalp, Martin W. Brechbiel
  • Bifunctional DTPA-type ligand
    Patent number: 5434287
    Abstract: The subject matter of the present invention relates to bifunctional cyclohexyl DPTA ligands and methods for utilizing these compounds.
    Type: Grant
    Filed: November 4, 1993
    Date of Patent: July 18, 1995
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Otto A. Gansow, Martin W. Brechbiel
  • Complexes of functionalized tetraazacyclododecane chelates with bismuth, lead, ytriium, actinium, or lanthanide metal ions
    Patent number: 5428154
    Abstract: The invention is a chelate of formula I: ##STR1## wherein R.sub.1-4 is --CH.sub.2 COOH;n is 1 to 5;X is a member selected from the group consisting of--NO.sub.2,--NH.sub.2,--NCS,--NHCOCH.sub.2 --Z, with Z being a member selected from the group consisting of Br and I,--COOH; and--OCH.sub.2 OOCH;and M is a metal ion selected from the group of elements consisting ofBi, Pb, Y, Cd, Hg, Al, Th, Sr, and Lanthanides.The invention also includes a chelate, wherein M is a copper ion and n is an integer from 2 to 5. The invention includes chelate conjugates of formula I and ligand conjugates of formula II: ##STR2## The invention also includes methods to use these compounds for treatment of cellular disorders and for diagnostic tests.
    Type: Grant
    Filed: October 22, 1993
    Date of Patent: June 27, 1995
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Otto A. Gansow, Martin W. Brechbiel, Michael A. Magerstadt
  • Antibody DTPA-type ligand conjugates
    Patent number: 5286850
    Abstract: The subject matter of the present invention relates to bifunctional cyclohexyl DPTA ligands and methods for utilizing these compounds. Antibody DTPA-type ligand conjugates are also provided.
    Type: Grant
    Filed: May 11, 1992
    Date of Patent: February 15, 1994
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Otto A. Gansoh, Martin W. Brechbiel
  • Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
    Patent number: 5246692
    Abstract: New polysubstituted diethylenetriaminepentaacetic acid chelates and protein conjugates of the same are described together with the methods of preparing such compounds. A method of delivering radiolabelled compound of the present invention to a target site while minimizing the distribution of the compound to non-targeted organs or tissues is also disclosed.
    Type: Grant
    Filed: August 22, 1991
    Date of Patent: September 21, 1993
    Assignee: The United States of America as represented by the Secretary of Health and Human Services
    Inventors: Otto A. Gansow, Martin W. Brechbiel
  • Bifunctional DTPA-type ligand
    Patent number: 5124471
    Abstract: The subject matter of the present invention relates to bifunctional cyclohexyl DPTA ligands and methods for utilizing these compounds.
    Type: Grant
    Filed: March 26, 1990
    Date of Patent: June 23, 1992
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Otto A. Gansow, Martin W. Brechbiel
  • Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
    Patent number: 5099069
    Abstract: New polysubstituted diethylenetriaminepentaacetic acid chelates and protein conjugates of the same are described together with the methods of preparing such compounds. A method of delivering radiolabelled compound of the present invention to a target site while minimizing the distribution of the compound to non-targeted organs or tissues is also disclosed.
    Type: Grant
    Filed: December 16, 1988
    Date of Patent: March 24, 1992
    Inventors: Otto A. Gansow, Martin W. Brechbiel
  • Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
    Patent number: 4831175
    Abstract: New polysubstituted diethylenetriaminepentaacetic acid chelates and protein conjugates of the same are described together with the methods of preparing such compounds. A method of delivering radiolabelled compound of the present invention to a target site while minimizing the distribution of the compound to non-targeted organs or tissues is also disclosed.
    Type: Grant
    Filed: September 5, 1986
    Date of Patent: May 16, 1989
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Otto A. Gansow, Martin W. Brechbiel