Abstract: The invention provides compounds that degrade the epidermal growth factor receptor (EGFR) including mutant forms via the ubiquitination of the EGFR protein and subsequent proteasomal degradation. The compounds are useful for the treatment of various cancers.

Abstract: A method for managing a main inventory of items across a distributed mobile work force, wherein each worker has a mobile computing device which includes a full complement of inventory management functions. Each mobile worker manages their own sub-inventory of items and a local database is stored on the mobile computing device containing a list of the items in the sub-inventory. As the worker distributes items from and receives items into the sub-inventory, the local database is updated by recording each transaction. The local database is synchronized with a main database containing a list of the main inventory such that any transactions performed on the sub-inventory are recorded in the main database and reflected in the main inventory.