Abstract: The present invention relates to an immobilized capping enzyme, preferably an immobilized Vaccinia virus capping enzyme. Furthermore, the present invention relates to an immobilized cap-specific nucleoside 2?-O-methyltransferase, preferably an immobilized Vaccinia virus cap-specific nucleoside 2?-O-methyltransferase. Moreover, the present invention relates to a method for immobilizing said enzymes and to a method of using said enzymes for the addition of a 5?-cap structure to RNAs. Moreover, the present invention relates to an enzyme reactor for performing the capping reaction using said immobilized enzymes and the subsequent separation of the 5?-capped RNA product. In addition, the present invention relates to a kit comprising the capping enzyme and/or the cap-specific nucleoside 2?-O-methyltransferase.

Abstract: A method, a system, and a computer program product for execution master data substitution. One or more first data objects in a master data storage are determined for replacement. One or more second data objects are identified for replacing the first data objects for storage in the master data storage. Replacement of the first data objects with the second data objects is performed in accordance with one or more data object requirements. Replacement of the first data objects by the second data objects is executed in accordance with the one or more data object requirements. A resulting replacement data set is generated and stored.

Abstract: A paver, in particular a slipform paver, has a machine frame supported by front and rear undercarriages and a paving device for the paving of material. The paver is provided with an apron monitoring device for generating elevation profile data or elevation profile signals describing the elevation profile of the material deposited in the apron of the paving device in a direction transverse to the working direction. A data or signal processing device receives the elevation profile data or signals. The apron monitoring device provides the data needed to allow the material to be spread more evenly across the working width of the paver during the feeding operation by means of a spreading device for spreading the material to be paved in a direction transverse to the working direction and/or to allow the spreading device to be controlled for improved spreading of the material after the paver has been fed.

Abstract: A system and method are provided for creating an image including quantified flow within vessels of a subject. The method includes providing a single-sweep, three-dimensional (3D) image volume acquired from a subject during a single pass of a computed tomography (CT) imaging system as the subject receives a dose of a contrast agent and determining a phase shift corresponding to pulsatile contrast in vessels within the single-sweep, 3D image volume. The method further includes quantifying a flow through the vessels within the single-sweep, 3D image volume using the phase shift and generating a report including indicating flow through the vessels within the 3D image volume.

Abstract: An aircraft propulsion unit includes an electric motor, at least one accessory unit used for operating the electric motor, an inverter module, the inverter module including a plurality of inverters for powering the electric motor and the at least one accessory unit, and a cooling system coupled to the electric motor and the inverter module, the cooling system comprising a coolant path for circulating a coolant through or adjacent to the electric motor and the at least one accessory unit.

Abstract: A door drive for arrangement on or in connection with a door system, whereby at least one leaf element of the door system is movable. The door drive includes a motor unit with a housing, in which a stator is stationarily received, and wherein a rotor is arranged so as to be rotationally-movable in the housing and includes an output shaft, wherein the output shaft can be brought into operative connection in a driving manner with the leaf element. The rotor includes a support body, on which receiving fields are formed, on which permanent magnets are adhered.

Abstract: The invention relates to computer-implemented systems and methods for analyzing medical images and records in various formats and structures from disparate sources and providers to provide answers to specific medical-related questions. An embodiment of the present invention is directed to accessing a health care form, identifying related text, leveraging computer vision technology to group nearby text, and applying deep learning models to identify fields from the text. This information may then be used to create a structured standardized output.

Abstract: A torsional probe for a metrology instrument includes a cantilever coupled to a support structure via a torsion bar. The cantilever, support structure, and arms of torsion bar have substantially the same thickness. A method of manufacture of the torsion probe, as well as a method of using the torsion probe to measure photothermal induced surface displacement of a sample are also described.

Abstract: The invention relates among other things to a cover assembly (10) with a first cover part (13) and a second cover part (14), where each cover part (13, 14) is movable relative to a base about a separate pivot axis between a closed position and an open position and is biased by a spring (16a, 16b) into the open position, where one leg (18) of the spring (16a, 16b) is supported on the base and one leg (17) loads the cover part (13, 14), and can be held in the closed position by a latch that is adjustable between a latching position and a release position, where the spring tension is adjustable by an adjuster (20).

Abstract: A door drive for arrangement on or in connection with a door system, wherein at least one leaf element of the door system is movable, including a motor unit with a housing, in which a stator is stationarily received, and wherein a rotor is arranged so as to be rotationally-movable in the housing and includes an output shaft, wherein the output shaft can be brought into operative connection in a driving manner with the leaf element. The motor unit has the basic shape of a cuboid, which is formed at least by two housing halves connected to each other.

Abstract: A method for determining and/or verifying a status of a door system, wherein the door system has at least one first subsystem and one second subsystem, includes the following steps determining at least one item of measurement information relating to the door system is determined in a measuring step, and determining and/or verifying the status of the door system using a model and using the at least one determined item of measurement information in a status determination step, wherein the model has a first model block for the first subsystem and a second model block for the second subsystem.

Abstract: A method for determining and/or verifying a status of a door system includes the following steps: determining at least one item of measurement information relating to the door system in a measuring step, and determining and/or verifying the status of the door system using an artificial intelligence system and using the at least one determined item of measurement information in a status determination step.

Abstract: The invention relates to computer-implemented systems and methods for identifying and further preventing commercial or contract leakage across multiple different procurement relationships. This may involve ingesting a contract extracting commercial terms, such as price, rates, etc. Invoices may be similarly ingested and commercial terms may be extracted on a line item basis. An embodiment of the present invention may identify various types of commercial leakage, such as rate/price discrepancies, full/partial duplication, unrealized discounts, unrealized rebates, disallowance of charges (travel expenses), etc.

Abstract: The present invention concerns antigen binding proteins directed against PRAME protein-derived antigens. The invention in particular provides antigen binding proteins which are specific for the tumor expressed antigen PRAME, wherein the tumor antigen comprises or consists of SEQ ID NO: 50 and is in a complex with a major histocompatibility complex (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said PRAME peptide. The antigen binding proteins of the invention are for use in the diagnosis, treatment and prevention of PRAME expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising said nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

Abstract: The present invention relates to an iron-based alloy powder containing non-spherical particles wherein the alloy comprises the elements Fe (iron), Cr (chrome) and Mo (molybdenum), and at least 40% of the total amount of particles have a non-spherical shape. In said iron-based alloy powder, Cr is present at 10.0 wt. % to 18.3 wt. %, Mo is present at 0.5 wt. % to 2.5 wt. %, C is present at 0 to 0.30 wt. %, Ni is present at 0 to 4.0 wt. %, Cu is present at 0 to 4.0 wt. %, Nb is present at 0 to 0.7 wt. %, Si is present at 0 to 0.7 wt. % and N is present at 0 to 0.20 wt. %, the balance up to 100 wt. % is Fe.

Abstract: The present invention relates to an iron-based alloy powder wherein the alloy comprises the elements Fe (iron), Cr (chrome) and Mo (molybdenum) and the iron-based alloy powder is produced by an ultra-high liquid atomization process comprising at least two stages as defined below.

Abstract: A radar system includes a local oscillator for generating a local oscillator signal, transmission channels, and a reception channel. The transmission channels are designed to generate and output RF radar signals based on the local oscillator signal The transmission channels have phase shifters for setting the phase of the RF radar signals. The reception channel is designed to receive an RF signal and to convert it into a baseband signal by using the local oscillator signal supplied thereto. A method includes operating the local oscillator in a CW mode, setting a specific combination of phase shifts for the phase shifters of the transmission channels, altering the phase of the local oscillator signal supplied to the reception channel or of the phase shifts of the phase shifters by a phase offset, and ascertaining that phase offset for which the baseband signal at least approximately assumes a maximum.

Abstract: A method of displaying player information in a casino using alternate reality includes generating a live video signal of a gaming environment using a camera on an electronic device; determining an identity of a player who is visible in the live video signal; retrieving information about the player from a database of registered players in response to the determined player identity; and displaying information about the player to a user of the electronic device so that the information appears to the user to be adjacent or on the player.

Abstract: Disclosed herein are compositions, uses, and methods for treatment of ovarian cancers. In one aspect, provided herein is a composition or medical preparation comprising at least one RNA, wherein the at least one RNA encodes the following amino acid sequences: (i) an amino acid sequence comprising claudin 6 (CLDN6), an immunogenic variant thereof, or an immunogenic fragment of the CLDN6 or the immunogenic variant thereof; (ii) an amino acid sequence comprising p53, an immunogenic variant thereof, or an immunogenic fragment of the p53 or the immunogenic variant thereof; and (iii) an amino acid sequence comprising Preferentially Expressed Antigen In Melanoma (PRAME), an immunogenic variant thereof, or an immunogenic fragment of the PRAME or the immunogenic variant thereof.