Patents by Inventor Martin Walko

Martin Walko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Delivery vehicle comprising a modified MscL protein channel
    Patent number: 7608582
    Abstract: The invention relates to the field of drug delivery, in particular, to compounds and methods for the chemical modification of a proteinaceous channel to be used in pharmaceutical delivery vehicles for controlled and/or localized release of therapeutic molecules (e.g., small molecules, peptides, proteins or other macromolecules). Provided are drug delivery vehicles comprising a pH- and/or light-responsive channel protein.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: October 27, 2009
    Assignee: Applied NanoSystems B.V.
    Inventors: Armagan Kocer, Martin Walko, George Thomas Robillard
  • Modified MscL protein channel
    Patent number: 7393828
    Abstract: The invention relates to the field of drug delivery, in particular, to compounds and methods for the chemical modification of a proteinaceous channel to be used in pharmaceutical delivery vehicles for controlled and/or localized release of therapeutic molecules (e.g., small molecules, peptides, proteins or other macromolecules). Provided are pH- and/or light-responsive compounds capable of controlling the channel activity of a mechanosensitive channel, such as the MscL channel protein of E. coli, or a functional equivalent thereof, and use of these compounds to convert a mechanosensitive channel protein into a pH- and/or light-responsive channel. Also provided are drug delivery vehicles comprising a pH- and/or light-responsive channel protein.
    Type: Grant
    Filed: May 19, 2006
    Date of Patent: July 1, 2008
    Assignee: Applied NanoSystems B.V.
    Inventors: Armagan Kocer, Martin Walko, George Thomas Robillard
  • Delivery vehicle comprising a modified MscL protein channel
    Publication number: 20080138401
    Abstract: The invention relates to the field of drug delivery, in particular, to compounds and methods for the chemical modification of a proteinaceous channel to be used in pharmaceutical delivery vehicles for controlled and/or localized release of therapeutic molecules (e.g., small molecules, peptides, proteins or other macromolecules). Provided are drug delivery vehicles comprising a pH- and/or light-responsive channel protein.
    Type: Application
    Filed: October 29, 2007
    Publication date: June 12, 2008
    Applicant: Applied NanoSystems B.V.
    Inventors: Armagan Kocer, Martin Walko, George Thomas Robillard
  • Modified MscL protein channel
    Publication number: 20060258587
    Abstract: The invention relates to the field of drug delivery, in particular, to compounds and methods for the chemical modification of a proteinaceous channel to be used in pharmaceutical delivery vehicles for controlled and/or localized release of therapeutic molecules (e.g., small molecules, peptides, proteins or other macromolecules). Provided are pH- and/or light-responsive compounds capable of controlling the channel activity of a mechanosensitive channel, such as the MscL channel protein of E. coli, or a functional equivalent thereof, and use of these compounds to convert a mechanosensitive channel protein into a pH- and/or light-responsive channel. Also provided are drug delivery vehicles comprising a pH- and/or light-responsive channel protein.
    Type: Application
    Filed: May 19, 2006
    Publication date: November 16, 2006
    Applicant: Applied NanoSystems B.V.
    Inventors: Armagan Kocer, Martin Walko, George Robillard