Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: Systems and methods for automatically animating a character based on an existing corpus of animation are described. The character may be from a previously produced feature animated film, and the data used for training may be the data used to animate the character in the film. A low-dimensional embedding for subsets of the existing animation corresponding to different semantic labels may be learned by mapping high-dimensional rig control parameters to a latent space. A particle model may be used to move within the latent space, thereby generating novel animations corresponding to the space's semantic label, such as a pose. Bridges may link a first pose of a first model within the latent space that is similar to a second pose of a second model of the space. Animations corresponding to transitions between semantic labels may be generated by creating animation paths that traverse a bridge from one model into another.

Abstract: Systems and methods for automatically animating a character based on an existing corpus of animation are described. The character may be from a previously produced feature animated film, and the data used for training may be the data used to animate the character in the film. A low-dimensional embedding for subsets of the existing animation corresponding to different semantic labels may be learned by mapping high-dimensional rig control parameters to a latent space. A particle model may be used to move within the latent space, thereby generating novel animations corresponding to the space's semantic label, such as a pose. Bridges may link a first pose of a first model within the latent space that is similar to a second pose of a second model of the space. Animations corresponding to transitions between semantic labels may be generated by creating animation paths that traverse a bridge from one model into another.

Abstract: Systems and methods for automatically animating a character based on an existing corpus of animation are described. The character may be from a previously produced feature animated film, and the data used for training may be the data used to animate the character in the film. A low-dimensional embedding for subsets of the existing animation corresponding to different semantic labels may be learned by mapping high-dimensional rig control parameters to a latent space. A particle model may be used to move within the latent space, thereby generating novel animations corresponding to the space's semantic label, such as a pose. Bridges may link a first pose of a first model within the latent space that is similar to a second pose of a second model of the space. Animations corresponding to transitions between semantic labels may be generated by creating animation paths that traverse a bridge from one model into another.

Abstract: Systems and methods for automatically animating a character based on an existing corpus of animation are described. The character may be from a previously produced feature animated film, and the data used for training may be the data used to animate the character in the film. A low-dimensional embedding for subsets of the existing animation corresponding to different semantic labels may be learned by mapping high-dimensional rig control parameters to a latent space. A particle model may be used to move within the latent space, thereby generating novel animations corresponding to the space's semantic label, such as a pose. Bridges may link a first pose of a first model within the latent space that is similar to a second pose of a second model of the space. Animations corresponding to transitions between semantic labels may be generated by creating animation paths that traverse a bridge from one model into another.

Abstract: A system for performing graphics processing is disclosed. A dependency graph comprising interconnected nodes is accessed. Each node has output attributes and the dependency graph receives input attributes. A first list is accessed, which includes a dirty status for each dirty output attribute of the dependency graph. A second list is accessed, which associates one of the input attributes with output attributes that are affected by the one input attribute. A third list is accessed, which associates one of the output attributes with output attributes that affect the one output attribute. An evaluation request for a requested output attribute is received. A set of output attributes are selected for evaluation based on being specified in the first list as dirty and being specified in the third list as associated with the requested output attribute. The set of output attributes are evaluated.

Abstract: A system for performing graphics processing is disclosed. A dependency graph comprising interconnected nodes is accessed. Each node has output attributes and the dependency graph receives input attributes. A first list is accessed, which includes a dirty status for each dirty output attribute of the dependency graph. A second list is accessed, which associates one of the input attributes with output attributes that are affected by the one input attribute. A third list is accessed, which associates one of the output attributes with output attributes that affect the one output attribute. An evaluation request for a requested output attribute is received. A set of output attributes are selected for evaluation based on being specified in the first list as dirty and being specified in the third list as associated with the requested output attribute. The set of output attributes are evaluated.

Abstract: An X-ray analysis apparatus for investigating material samples, comprising a device for automatic exchange of the samples (1), which comprises a sample table (2) with depositing positions (3) disposed in m lines, wherein the lines extend parallel to an x direction and m≧2, and comprising a gripping device (4) for precise removal of any desired sample (1) from a depositing position (3) and for transfer into a transfer and/or measuring position (5) and back to a depositing position (3), wherein the gripping device (4) can be displaced linearly parallel to the x direction, is characterized in that the sample table (2) can be moved linearly parallel to a y direction, extending at an angle &agr; to the x direction, and independently of the gripping device (4) for gripping samples (1) from different lines, wherein the sample table (2) is disposed parallel to the x-y plane.

Abstract: An X-ray analysis apparatus for investigating material samples, comprising a device for automatic exchange of the samples (1), which comprises a gripping device (4) for precise removal of any desired sample (1) from a depositing position (3) and for transfer into a transfer and/or measuring position and back to a depositing position (3), wherein at least some of the samples are surrounded by a sample holder (13;13′) in the peripheral direction, is characterized in that the samples or containers containing the samples project past the sample holder in the vertical z direction perpendicular to the horizontal x-y plane and that the gripping device is disposed and structured on a side of the sample to surround parts of a sample or of a sample container which project past the sample holder in an operating position in the z direction and to grasp the sample holder.

Abstract: An X-ray analysis apparatus for investigating material samples, comprising a device for automatic exchange of the samples (1), which comprises a sample table (2) with depositing positions (3) disposed in m lines, wherein the lines extend parallel to an x direction and m≧2, and comprising a gripping device (4) for precise removal of any desired sample (1) from a depositing position (3) and for transfer into a transfer and/or measuring position (5) and back to a depositing position (3), wherein the gripping device (4) can be displaced linearly parallel to the x direction, is characterized in that the sample table (2) can be moved linearly parallel to a y direction, extending at an angle &agr; to the x direction, and independently of the gripping device (4) for gripping samples (1) from different lines, wherein the sample table (2) is disposed parallel to the x-y plane.

Abstract: An X-ray analysis apparatus for investigating material samples, comprising a device for automatic exchange of the samples (1), which comprises a gripping device (4) for precise removal of any desired sample (1) from a depositing position (3) and for transfer into a transfer and/or measuring position and back to a depositing position (3), wherein at least some of the samples are surrounded by a sample holder (13;13′) in the peripheral direction, is characterized in that the samples or containers containing the samples project past the sample holder in the vertical z direction perpendicular to the horizontal x-y plane and that the gripping device is disposed and structured on a side of the sample to surround parts of a sample or of a sample container which project past the sample holder in an operating position in the z direction and to grasp the sample holder.

Abstract: A wear indicator is provided for a rotary drilling tool of the type which comprises a bit body having a leading surface for cutting, abrading or reaming a hole in a target substrate material such as a sub-surface formation, the wear indicator comprising or including one or more discrete areas of a visually distinct material to that from which the drilling tool is mainly composed, the visually distinct material being arranged or configured at or adjacent the surface of the bit such that progressive wear of the bit and hence the or each visually distinct discrete area provides a visual indication of surface wear of the tool.