Patents by Inventor Martin Watterson
Martin Watterson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11566016Abstract: The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38? MAP kinase inhibitors. The invention further provides for methods for treatment of diseases comprising administration of MAP kinase inhibitors or compositions comprising MAP kinase inhibitors. In some embodiments, the disease is Alzheimer's Disease, ALS, Huntington's Disease or Parkinson's Disease.Type: GrantFiled: September 16, 2021Date of Patent: January 31, 2023Assignees: The Trustees of Columbia University in the City of New York, Northwestern UniversityInventors: Ottavio Arancio, Daniel Martin Watterson, Jeffrey Claude Pelletier, Saktimayee Mitra Roy
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Publication number: 20220009905Abstract: The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38? MAP kinase inhibitors. The invention further provides for methods for treatment of diseases comprising administration of MAP kinase inhibitors or compositions comprising MAP kinase inhibitors. In some embodiments, the disease is Alzheimer's Disease, ALS, Huntington's Disease or Parkinson's Disease.Type: ApplicationFiled: September 16, 2021Publication date: January 13, 2022Inventors: Ottavio ARANCIO, Daniel Martin WATTERSON, Jeffrey Claude PELLETIER, Saktimayee Mitra ROY
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Patent number: 11149020Abstract: The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38? MAP kinase inhibitors. The invention further provides for methods for treatment of diseases comprising administration of MAP kinase inhibitors or compositions comprising MAP kinase inhibitors. In some embodiments, the disease is Alzheimer's Disease, ALS, Huntington's Disease or Parkinson's Disease.Type: GrantFiled: August 27, 2019Date of Patent: October 19, 2021Assignees: The Trustees of Columbia University in the City of New York, Northwestern UniversityInventors: Ottavio Arancio, Daniel Martin Watterson, Jeffrey Claude Pelletier, Saktimayee Mitra Roy
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Publication number: 20190389840Abstract: The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38? MAP kinase inhibitors. The invention further provides for methods for treatment of diseases comprising administration of MAP kinase inhibitors or compositions comprising MAP kinase inhibitors. In some embodiments, the disease is Alzheimer's Disease, ALS, Huntington's Disease or Parkinson's Disease.Type: ApplicationFiled: August 27, 2019Publication date: December 26, 2019Inventors: Ottavio ARANCIO, Daniel Martin WATTERSON, Jeffrey Claude PELLETIER, Saktimayee Mitra ROY
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Patent number: 10428047Abstract: The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38? MAP kinase inhibitors. The invention further provides for methods for treatment of diseases comprising administration of MAP kinase inhibitors or compositions comprising MAP kinase inhibitors. In some embodiments, the disease is Alzheimer's Disease, ALS, Huntington's Disease or Parkinson's Disease.Type: GrantFiled: September 7, 2017Date of Patent: October 1, 2019Assignees: The Trustees of Columbia University in the City of New York, Northwestern UniversityInventors: Ottavio Arancio, Daniel Martin Watterson, Jeffrey Claude Pelletier, Saktimayee Mitra Roy
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Publication number: 20170369472Abstract: The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38? MAP kinase inhibitors. The invention further provides for methods for treatment of diseases comprising administration of MAP kinase inhibitors or compositions comprising MAP kinase inhibitors. In some embodiments, the disease is Alzheimer's Disease, ALS, Huntington's Disease or Parkinson's Disease.Type: ApplicationFiled: September 7, 2017Publication date: December 28, 2017Inventors: Ottavio ARANCIO, Daniel Martin WATTERSON, Jeffrey Claude PELLETIER, Saktimayee Mitra ROY
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Patent number: 9783525Abstract: The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38? MAP kinase inhibitors. The invention further provides for methods for treatment of diseases comprising administration of MAP kinase inhibitors or compositions comprising MAP kinase inhibitors. In some embodiments, the disease is Alzheimer's Disease, ALS, Huntington's Disease or Parkinson's Disease.Type: GrantFiled: September 15, 2015Date of Patent: October 10, 2017Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, NORTHWESTERN UNIVERSITYInventors: Ottavio Arancio, Daniel Martin Watterson, Jeffrey Claude Pelletier, Saktimayee Mitra Roy
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Patent number: 9663493Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.Type: GrantFiled: June 29, 2016Date of Patent: May 30, 2017Assignees: Northwestern University, Universite De Strasbourg, Centre National De La Recherche Scientifique (CNRS)Inventors: D. Martin Watterson, Linda Van Eldik, Jacques Haiech, Marcel Hibert, Jean-Jacques Bourguignon, Anastasia Velentza, Wenhui Hu, Magdalena Zasadzki
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Patent number: 9527819Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.Type: GrantFiled: December 3, 2014Date of Patent: December 27, 2016Assignees: NORTHWESTERN UNIVERSITY, UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: D. Martin Watterson, Linda Van Eldik, Jacques Haiech, Marcel Hibert, Jean-Jacques Bourguignon, Anastasia Velentza, Wenhui Hu, Magdalena Zasadzki
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Publication number: 20160326139Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.Type: ApplicationFiled: June 29, 2016Publication date: November 10, 2016Applicants: NORTHWESTERN UNIVERSITY, UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: D. Martin WATTERSON, Linda VAN ELDIK, Jacques HAIECH, Marcel HIBERT, Jean-Jacques BOURGUIGNON, Anastasia VELENTZA, Wenhui HU, Magdalena ZASADZKI
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Patent number: 9408845Abstract: The invention relates to chemical compounds, compositions and methods of making and using the same. In particular, the invention provides selected pyridazine compounds of the formula I wherein R1, R4, R5, R6, R7, R8, R9, R12, R13 ET R14 are independently hydrogen, hydroxyl, alkyl, alkenyl, alkynyl, alkylene, alkenylene, alkoxy, alkenyloxy, cycloalkyl, cycloalkenyl, cycloalkynyl, cycloalkoxy, aryl, aryloxy, arylalkoxy, aroyl, heteroaryl, heterocyclic, acyl, acyloxy, amino, imino, azido, thiol, thioallyl, thioalkoxy, thioaryl, nitro, cyano, halo, sulfate, sulfonyl, sulfinyl, sulfonyl, sultanate, sulfoxide, silyl, silyloxy, silylalkyl, silylthio, ?O, ?S, phosphonate, ureido, carboxyl, carbonyl, carbamoyl, or carboxamide; and X is optionally substituted pyrimidinyl or pyridazinyl, an isomer, a pharmaceutically acceptable salt, or derivative thereof.Type: GrantFiled: October 25, 2012Date of Patent: August 9, 2016Assignee: Northwestern UniversityInventors: D. Martin Watterson, Linda Van Eldik, Wenhui Hu
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Publication number: 20160151366Abstract: Methods and compositions for use in treating autism spectrum disorder (ASD) include use of specific CNS penetrant p38? MAPK inhibitors having the structure of formula (I)Type: ApplicationFiled: November 17, 2015Publication date: June 2, 2016Inventors: Randy D. Blakely, Jeremy Veenstra-Vanderweele, Matthew J. Robson, D. Martin Watterson
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Publication number: 20160130253Abstract: The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38? MAP kinase inhibitors. The invention further provides for methods for treatment of diseases comprising administration of MAP kinase inhibitors or compositions comprising MAP kinase inhibitors. In some embodiments, the disease is Alzheimer's Disease, ALS, Huntington's Disease or Parkinson's Disease.Type: ApplicationFiled: September 15, 2015Publication date: May 12, 2016Inventors: Ottavio ARANCIO, Daniel Martin WATTERSON, Jeffrey Claude PELLETIER, Saktimayee Mitra ROY
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Publication number: 20150175555Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.Type: ApplicationFiled: December 3, 2014Publication date: June 25, 2015Applicants: NORTHWESTERN UNIVERSITY, UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: D. Martin WATTERSON, Linda VAN ELDIK, Jacques HAIECH, Marcel HIBERT, Jean-Jacques BOURGUIGNON, Anastasia VELENTZA, Wenhui HU, Magdalena ZASADZKI
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Patent number: 8933076Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for, research, drug screening, and therapeutic applications.Type: GrantFiled: June 8, 2012Date of Patent: January 13, 2015Assignees: Centre National de la Recherche Scientifique (CNRS), Northwestern University, Universite de StrasbourgInventors: D. Martin Watterson, Linda Van Eldik, Jacques Haiech, Marcel Hibert, Jean-Jacques Bourguignon, Anastasia Velentza, Wenhui Hu, Magdalena Zasadzki
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Patent number: 8791116Abstract: Pyridazinyl compounds, compositions and related methods of use.Type: GrantFiled: October 1, 2012Date of Patent: July 29, 2014Assignee: Northwestern UniversityInventors: Daniel Martin Watterson, Linda J. Van Eldik, Heather Behanna, Hantamalala Ralay Ranaivo
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Patent number: 8367672Abstract: The invention relates to novel chemical compounds and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.Type: GrantFiled: November 2, 2005Date of Patent: February 5, 2013Assignees: Universite de Strasbourg, Northwestern University, Centre National de la Recherche Scientifique (CNRS)Inventors: D. Martin Watterson, Linda J. Van Eldik, Jacques Haiech, Marcel Hibert, Jean-Jacques Bourguignon, Anastasia Velentza, Wenhui Hu, Magdalena Zasadzki
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Publication number: 20130029999Abstract: Pyridazinyl compounds, compositions and related methods of use.Type: ApplicationFiled: October 1, 2012Publication date: January 31, 2013Applicant: NORTHWESTERN UNIVERSITYInventors: DANIEL MARTIN WATTERSON, LINDA J. VAN ELDIK, HEATHER BEHANNA, HANTAMALALA RALAY RANAIVO
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Patent number: 8278305Abstract: Pyridazinyl compounds, compositions and related methods of use.Type: GrantFiled: May 25, 2010Date of Patent: October 2, 2012Assignee: Northwestern UniversityInventors: Daniel Martin Watterson, Linda J. Van Eldik, Heather Behanna, Hantamalala Ralay Ranaivo
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Publication number: 20120245125Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for, research, drug screening, and therapeutic applications.Type: ApplicationFiled: June 8, 2012Publication date: September 27, 2012Applicants: Northwestern UniversityInventors: D. Martin Watterson, Linda Van Eldik, Jacques Haiech, Marcel Hibert, Jean-Jacques Bourguignon, Anastasia Velentza, Wenhui Hu, Magdalena Zasadzki