Abstract: The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. The present invention further relates to a sulfonamide of formula (A). Moreover, the present invention relates to an insulin analog comprising at least one mutation relative to the parent insulin.

Abstract: Some embodiments provide a non-transitory machine-readable medium that stores a program. The program receives a set of audio files. Each audio file in the set of audio files includes audio from an audio call. The program further truncates each audio file in the set of audio files to a defined call length. For each audio call in the set of audio calls, the program also receives a transcript of the audio call based on the audio file of the audio call. For each audio call in the set of audio calls, the program further uses the transcript of the audio call as input to a machine learning model for the machine learning model to predict a category from a plurality of categories that is associated with the audio call.

Abstract: A method may include collecting data from a variety of data sources associated with a user. The data sources may include personal data sources, corporate data sources, and public data source. The data collected from the variety of data sources may be enriched through categorization and aggregation. For example, browser history may be categorized based on types of website and aggregated to reflect the quantity of interactions with each category of website. A multi-dimensional digital profile may be generated based on the enriched data. For instance, the digital profile may include a social, emotional, spiritual, environmental, occupational, intellectual, and physical dimension. One or more recommendation corresponding to one or more of a burnout prediction, wellness recommendation, learning plan, skill gap, and personality type may be generated based on the digital profile. Related systems and computer program products are also provided.

Abstract: A method may include collecting data from a variety of data sources associated with a user. The data sources may include personal data sources, corporate data sources, and public data source. The data collected from the variety of data sources may be enriched through categorization and aggregation. For example, browser history may be categorized based on types of website and aggregated to reflect the quantity of interactions with each category of website. A multi-dimensional digital profile may be generated based on the enriched data. For instance, the digital profile may include a social, emotional, spiritual, environmental, occupational, intellectual, and physical dimension. One or more recommendation corresponding to one or more of a burnout prediction, wellness recommendation, learning plan, skill gap, and personality type may be generated based on the digital profile. Related systems and computer program products are also provided.

Abstract: A compound, e g a diamine ligand, represented by the following general formula (1): (Formula (1)) wherein each * represents an asymmetric carbon atom; X represents a group selected from one of an ester (e.g. a t-butyl ester); a thioester; an amide; a heterocyclic moiety (e.g. a five-membered heterocyclic ring) comprising one or more of O, S, Se, and/or P (e.g. a furan, a tetrahydrofuran, a thiophene, an isoxazole, a bromo-furan, or a thiazole); a moiety (e.g. a five-membered heterocyclic ring) comprising a nitrogen atom, wherein the nitrogen atom is protected with a protecting group containing an electron-withdrawing group, preferably the protecting group is selected from one of a carbamate protecting group, an amide protecting group, an aryl sulphonamide protecting group, or an alkyl sulphonamide protecting group; and optionally X may additionally comprise a solid support, e.g.

Abstract: The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. The present invention further relates to a sulfonamide of formula (A). Moreover, the present invention relates to an insulin analog comprising at least one mutation relative to the parent insulin.

Abstract: Some embodiments provide a non-transitory machine-readable medium that stores a program. The program receives a set of audio files. Each audio file in the set of audio files includes audio from an audio call. The program further truncates each audio file in the set of audio files to a defined call length. For each audio call in the set of audio calls, the program also receives a transcript of the audio call based on the audio file of the audio call. For each audio call in the set of audio calls, the program further uses the transcript of the audio call as input to a machine learning model for the machine learning model to predict a category from a plurality of categories that is associated with the audio call.

Abstract: The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. The present invention further relates to a sulfonamide of formula (A). Moreover, the present invention relates to an insulin analog comprising at least one mutation relative to the parent insulin.

Abstract: Disclosed are methods for the preparation of ligands for complexes, methods for preparing complexes and complexes having those ligands. Also provided is the use of a complex as a catalyst in a method of synthesis.

Abstract: The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. The present invention further relates to a sulfonamide of formula (A). Moreover, the present invention relates to an insulin analog comprising at least one mutation relative to the parent insulin.

Abstract: The invention relates to a method for synthesizing tethered ruthenium catalysts and novel tethered ruthenium catalysts obtainable by this methods. The method involves carrying out an “arene swapping” reaction avoiding the requirement to use complicated techniques making use of unreliable Birch reductions and unstable cyclodienyl intermediates.

Abstract: The invention relates to a method for synthesising tethered ruthenium catalysts and novel tethered ruthenium catalysts obtainable by this methods. The method involves carrying out an “arene swapping” reaction avoiding the requirement to use complicated techniques making use of unreliable Birch reductions and unstable cyclodienyl intermediates.

Abstract: In various embodiments, Methods, systems, computer-readable storage media, and apparatuses are described for determining interactions between geometric objects stored on distributed computing nodes. Nodes may be configured to perform a join operation in response to a query. The worker nodes may perform a source stage where source geometric objects are identified and sent to other worker nodes. The worker nodes may perform a target stage a set of target geometric objects is identified and a join operation performed on the received source and target geometric objects. The worker nodes may also perform a join operation that is based on storage of geometric objects in a storage sieve tree structure (“SST”). A space-filling curve may be used to map levels of the SST to a one-dimensional interval. The join operation may be performed only on objects whose mapped portions of the interval overlap. Other embodiments, may be described and claimed.

Abstract: The present invention relates to a method for coating substrates, including applying a composition to a first side of the substrate, the composition containing an inorganic compound, drying the applied composition, applying at least one coating to the first side of the substrate to which the composition is applied, the coating containing a silane, drying the applied coating, and applying at least one barrier layer to a second side of the substrate.

Abstract: Methods, computer-readable storage media, and apparatuses for determining interactions between geometric shapes on a geoid may be described. In embodiments, queries about geometric shapes on a geoid may be received. Various interaction tests, such as point-point or point-segment intersection tests, may be identified that need to be determined to satisfy the query. Points for the geometric shapes may be projected onto an auxiliary sphere that is associated with the geoid. The tests may be performed using these projected points, and from the results of these tests, a response may be provided to the query. Approximate computations, such as limited-precision CPU-based computations, may also be utilized to reduce computational complexity during test performance. An error value may be determined during performance of these tests, and, if the error value is greater than a pre-determined error bound, the test may be performed using higher-precision computations. Additional embodiments may be described and claimed.

Abstract: A method for coating substrates, containing a) applying a composition to a first side of a substrate, the composition containing an inorganic compound and the inorganic compound containing a metal such as Sc, Y, Ti, Zr, Nb, V, Cr, Mo, W, Mn, Fe, Co, B, Al, In, Tl, Si, Ge, Sn, Zn, Pb, Sb, or Bi, and an element such as Te, Se, S, O, Sb, As, P, N, C, or Ga, b) drying the composition, c) applying a coating to the first side of the substrate, the coating containing a silane, oxide particles of Ti, Si, Zr, Al, Y, Sn, Zn, Ce or mixtures thereof, a polymer and an initiator, d) drying the coating, e) applying a barrier layer to a second side of the substrate, and f) drying the barrier layer to form a dry barrier layer.

Abstract: The invention relates to a communication system for a motor vehicle for transmitting an information relating to the operation of the motor vehicle from a transmitting control device to a receiving control device. The communication system comprises an interface for the input or output of the information relating to the operation of the motor vehicle. Communication can be established via the interface by means of a protocol which comprises an operation field for identifying a task to be carried out using the information relating to the operation of the motor vehicle.

Abstract: A control system for a motor vehicle comprises an output control unit for outputting data related to the operation of the motor vehicle and an operation control unit spatially separated from the output control unit for generating or providing data related to the operation of the motor vehicle. The output control unit comprises a data storage for storing data related to the operation of the motor vehicle and the data related to the operation of the motor vehicle can be read out of the data storage and outputted by the output control unit.

Abstract: The present invention relates to a method for coating substrates, including applying a composition to a first side of the substrate, the composition containing an inorganic compound, drying the applied composition, applying at least one coating to the first side of the substrate to which the composition is applied, the coating containing a silane, drying the applied coating, and applying at least one barrier layer to a second side of the substrate.

Abstract: An integrated genomic system is a software system that facilitates data management and analysis connected with integrated genomic research, such as statistical genetics. Reference information, biological and experimental, describes context from which experiments are made. Reference information, including annotations for genes, markers, study, individuals, and so on, is input into the integrated genomic system for consolidation, accessibility, and linkage with other data to aid researchers to view influences and interactions in biological systems.