Abstract: Methods for using SQL statements to access an application-server-managed database are disclosed herein. In some embodiments, a user sends, either directly or indirectly (i.e., remotely) a SQL statement from an ODBC application or server, respectively, to an application server that preprocesses SQL statements for accessing data from a centralized database. The application server may have a SQL endpoint, and access to the SQL endpoint may be determined by a user's logon credentials, a user's presentation of a SAML token, or a user's presentation of a valid certificate. The application server may then parse the SQL statement and determine the user's authorization to access certain objects in the centralized database based on a SQL handler design-time configuration. A result from the statement may be sent back to the user either directly or indirectly and exposed.

Abstract: A method may include collecting data from a variety of data sources associated with a user. The data sources may include personal data sources, corporate data sources, and public data source. The data collected from the variety of data sources may be enriched through categorization and aggregation. For example, browser history may be categorized based on types of website and aggregated to reflect the quantity of interactions with each category of website. A multi-dimensional digital profile may be generated based on the enriched data. For instance, the digital profile may include a social, emotional, spiritual, environmental, occupational, intellectual, and physical dimension. One or more recommendation corresponding to one or more of a burnout prediction, wellness recommendation, learning plan, skill gap, and personality type may be generated based on the digital profile. Related systems and computer program products are also provided.

Abstract: A method may include collecting data from a variety of data sources associated with a user. The data sources may include personal data sources, corporate data sources, and public data source. The data collected from the variety of data sources may be enriched through categorization and aggregation. For example, browser history may be categorized based on types of website and aggregated to reflect the quantity of interactions with each category of website. A multi-dimensional digital profile may be generated based on the enriched data. For instance, the digital profile may include a social, emotional, spiritual, environmental, occupational, intellectual, and physical dimension. One or more recommendation corresponding to one or more of a burnout prediction, wellness recommendation, learning plan, skill gap, and personality type may be generated based on the digital profile. Related systems and computer program products are also provided.

Abstract: A compound, e g a diamine ligand, represented by the following general formula (1): (Formula (1)) wherein each * represents an asymmetric carbon atom; X represents a group selected from one of an ester (e.g. a t-butyl ester); a thioester; an amide; a heterocyclic moiety (e.g. a five-membered heterocyclic ring) comprising one or more of O, S, Se, and/or P (e.g. a furan, a tetrahydrofuran, a thiophene, an isoxazole, a bromo-furan, or a thiazole); a moiety (e.g. a five-membered heterocyclic ring) comprising a nitrogen atom, wherein the nitrogen atom is protected with a protecting group containing an electron-withdrawing group, preferably the protecting group is selected from one of a carbamate protecting group, an amide protecting group, an aryl sulphonamide protecting group, or an alkyl sulphonamide protecting group; and optionally X may additionally comprise a solid support, e.g.

Abstract: The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. The present invention further relates to a sulfonamide of formula (A). Moreover, the present invention relates to an insulin analog comprising at least one mutation relative to the parent insulin.

Abstract: Some embodiments provide a non-transitory machine-readable medium that stores a program. The program receives a set of audio files. Each audio file in the set of audio files includes audio from an audio call. The program further truncates each audio file in the set of audio files to a defined call length. For each audio call in the set of audio calls, the program also receives a transcript of the audio call based on the audio file of the audio call. For each audio call in the set of audio calls, the program further uses the transcript of the audio call as input to a machine learning model for the machine learning model to predict a category from a plurality of categories that is associated with the audio call.

Abstract: The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. The present invention further relates to a sulfonamide of formula (A). Moreover, the present invention relates to an insulin analog comprising at least one mutation relative to the parent insulin.

Abstract: Disclosed are methods for the preparation of ligands for complexes, methods for preparing complexes and complexes having those ligands. Also provided is the use of a complex as a catalyst in a method of synthesis.

Abstract: The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. The present invention further relates to a sulfonamide of formula (A). Moreover, the present invention relates to an insulin analog comprising at least one mutation relative to the parent insulin.

Abstract: Disclosed are methods for the preparation of ligands for complexes, methods for preparing complexes and complexes having those ligands. Also provided is the use of a complex as a catalyst in a method of synthesis.

Abstract: The invention relates to a method for synthesizing tethered ruthenium catalysts and novel tethered ruthenium catalysts obtainable by this methods. The method involves carrying out an “arene swapping” reaction avoiding the requirement to use complicated techniques making use of unreliable Birch reductions and unstable cyclodienyl intermediates.

Abstract: In various embodiments, Methods, systems, computer-readable storage media, and apparatuses are described for determining interactions between geometric objects stored on distributed computing nodes. Nodes may be configured to perform a join operation in response to a query. The worker nodes may perform a source stage where source geometric objects are identified and sent to other worker nodes. The worker nodes may perform a target stage a set of target geometric objects is identified and a join operation performed on the received source and target geometric objects. The worker nodes may also perform a join operation that is based on storage of geometric objects in a storage sieve tree structure (“SST”). A space-filling curve may be used to map levels of the SST to a one-dimensional interval. The join operation may be performed only on objects whose mapped portions of the interval overlap. Other embodiments, may be described and claimed.

Abstract: The invention relates to a method for synthesising tethered ruthenium catalysts and novel tethered ruthenium catalysts obtainable by this methods. The method involves carrying out an “arene swapping” reaction avoiding the requirement to use complicated techniques making use of unreliable Birch reductions and unstable cyclodienyl intermediates.

Abstract: Methods, computer-readable storage media, and apparatuses for determining interactions between geometric shapes on a geoid may be described. In embodiments, queries about geometric shapes on a geoid may be received. Various interaction tests, such as point-point or point-segment intersection tests, may be identified that need to be determined to satisfy the query. Points for the geometric shapes may be projected onto an auxiliary sphere that is associated with the geoid. The tests may be performed using these projected points, and from the results of these tests, a response may be provided to the query. Approximate computations, such as limited-precision CPU-based computations, may also be utilized to reduce computational complexity during test performance. An error value may be determined during performance of these tests, and, if the error value is greater than a pre-determined error bound, the test may be performed using higher-precision computations. Additional embodiments may be described and claimed.

Abstract: An integrated genomic system is a software system that facilitates data management and analysis connected with integrated genomic research, such as statistical genetics. Reference information, biological and experimental, describes context from which experiments are made. Reference information, including annotations for genes, markers, study, individuals, and so on, is input into the integrated genomic system for consolidation, accessibility, and linkage with other data to aid researchers to view influences and interactions in biological systems.

Abstract: The invention provides the use of a metal complex, which is a complex of one or more metal atoms or ions with one or more ligands, as a catalyst in an organic transformation selected from hydrogenation of carbon-heteroatom double bonds, hydroformylation, dialkylzinc additions to aldehydes, hydrocarboxylation, allylic substitution, oxidation, epoxidation, dihydroxylation, Diels-Alder cycloadditions, dipolar cycloadditions and rearrangement reactions, wherein one or more of the ligands is a ligand of formula (1), wherein the bridge group is an organic functional group, and the R group is a substituted phenyl group, wherein the R group has only one substituent at the ortho position, and wherein a carbon atom of the R group bonds the R group to the P atom.

Abstract: A turbine nozzle includes a hollow vane having opposite pressure and suction sides extending in span between outer and inner bands. The vane includes a forward flow channel behind the leading edge, an aft flow channel in front of the trailing edge, and a middle flow channel disposed therebetween. The three flow channels are disposed in flow communication with an outer plenum outside the outer band for receiving cooling air therefrom. The forward and middle channels are also disposed in flow communication with an inner plenum below the inner band for discharging the air. The aft channel discharges air through the inner band outside the inner plenum in split flow at different pressures.

Abstract: The application relates to diazaphospholidine compounds of Formula 1 and Formula 2: where: A and B are independently selected from C(R22R23) and C(R22R23)C(R24R25); R1, R2, R3, R4, R18, R19, R20, R21, R22, R23, R24 and R25 each may not be present and each may be independently selected from H, halide —OH, —SO2R26 (where R26 is selected from a group as defined for R22, R23, R24 and R25), —SH, —NO2, —NH2, ═O, ═S, straight chain, branched chain, cyclic, saturated, non-saturated, substituted or non-substituted alkyl, hydroalkyl, carboalkyl, alkoxy, amino, alkenyl, aryl and —CH2 Ar (where Ar is aryl or substituted aryl), preferably containing 1 to 6 carbons, or a silane containing 1 to 6 silicon atoms, wherein, where an R1, R2, R3, R4, R18, R19, R20, R21, R22, R23, R24 and/or R25 group is not present an unsaturated bond is formed; R5 and R17 are selected from H, —NH2, —OH, halide or a substituted or non-substituted strai

Abstract: In the course of a method for the structural analysis of a chemical compound by data signals measured with the chemical compound being compared with calculated data, a first data signal is generated for at least one first compound having a structure which is similar to the assumed structure and has the same first substructure, but a different substituent Sv (instead of the substituent Sa of the compound being studied) in the substitution position; a second data signal is generated which constitutes the difference between the data from a second Sv-substituted compound and an unsubstituted (third) compound; a third data signal is generated which constitutes the difference between the data from a fourth Sa-substituted compound and an unsubstituted compound; a fourth data signal is generated from the first three data signals, and the measured data signal and the fourth data signal are compared with one another.