Abstract: Embodiments of the invention provide for the guided navigation of an ultrasound probe. In an embodiment of the invention, an ultrasound navigation assistance method includes acquiring an image by an ultrasound probe of a target organ of a body. The method also includes processing the image in connection with an estimator such as a neural network. The processing in turn determines a deviation of a contemporaneous pose evident from the acquired image from an optimal pose of the ultrasound probe for imaging the target organ. Finally, the method includes presenting the computed deviation to an end user operator of the ultrasound probe.