Patents by Inventor Martin Zillmann

Martin Zillmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11326154
    Abstract: The present invention relates to fusion proteins comprising an N-intein polypeptide and an N-intein solubilization partner, and affinity chromatography matrices comprising such fusion proteins, as well as methods of using same.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: May 10, 2022
    Assignee: Merck Patent GmbH
    Inventors: Martin Zillmann, Joe Orlando
  • Publication number: 20220088200
    Abstract: The present invention relates to compositions of highly concentrated protein formulations showing reduced viscosity.
    Type: Application
    Filed: December 6, 2021
    Publication date: March 24, 2022
    Applicant: Merck Patent GmbH
    Inventors: Martin ZILLMANN, Alexandra KROG, Raphael GUEBELI, Tanja HENZLER, Christian HILDEBRANDT
  • Patent number: 11207412
    Abstract: The present invention relates to compositions of highly concentrated protein formulations showing reduced viscosity. The contained proteins in the prepared formulations are stabilized against aggregation and denaturation and are thus sufficiently storage-stable until administration to the patient.
    Type: Grant
    Filed: April 16, 2019
    Date of Patent: December 28, 2021
    Assignee: Merck Patent GmbH
    Inventors: Martin Zillmann, Alexandra Krog, Raphael Guebeli, Tanja Henzler, Christian Hildebrandt
  • Publication number: 20210238222
    Abstract: Processes for producing recombinant proteins having low levels of residual host cell proteins. The processes comprise utilizing engineered host cell lines in which specific host cell proteins are tagged with purification tags, wherein the purification tags can be used to remove those specific host cell proteins from the recombinant proteins.
    Type: Application
    Filed: May 3, 2019
    Publication date: August 5, 2021
    Inventors: Trissa Borgschulte, Joaquina Mascarenhas, Martin Zillmann, Frank Swartzwelder, Kevin Kayser
  • Publication number: 20190314505
    Abstract: The present invention relates to compositions of highly concentrated protein formulations showing reduced viscosity.
    Type: Application
    Filed: April 16, 2019
    Publication date: October 17, 2019
    Applicant: Merck Patent GmbH
    Inventors: Martin ZILLMANN, Alexandra KROG, Raphael GUEBELI, Tanja HENZLER, Christian HILDEBRANDT
  • Publication number: 20190241609
    Abstract: The present invention relates to fusion proteins comprising an N-intein polypeptide and an N-intein solubilization partner, and affinity chromatography matrices comprising such fusion proteins, as well as methods of using same.
    Type: Application
    Filed: April 18, 2019
    Publication date: August 8, 2019
    Inventors: Martin Zillmann, Joe Orlando
  • Patent number: 10308679
    Abstract: The present invention relates to fusion proteins comprising an N-intein polypeptide and an N-intein solubilization partner, and affinity chromatography matrices comprising such fusion proteins, as well as methods of using same.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: June 4, 2019
    Assignee: Merck Patent GmbH
    Inventors: Martin Zillmann, Joe Orlando
  • Publication number: 20170291919
    Abstract: The present invention relates to fusion proteins comprising an N-intein polypeptide and an N-intein solubilization partner, and affinity chromatography matrices comprising such fusion proteins, as well as methods of using same.
    Type: Application
    Filed: October 23, 2015
    Publication date: October 12, 2017
    Inventors: Martin Zillmann, Joe Orlando
  • Publication number: 20130040293
    Abstract: Methods for determining genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information.
    Type: Application
    Filed: March 5, 2012
    Publication date: February 14, 2013
    Inventors: JEFFREY OLSON, MARTIN ZILLMANN, VINCENT P. STANTON, JR.
  • Publication number: 20120070836
    Abstract: The present invention relates to methods of detecting residual amounts of polymers including stimulus responsive polymers, which are used in processes for purifying biomolecules such as, for example, proteins, polypeptides, antibodies, vaccines and the like.
    Type: Application
    Filed: June 8, 2011
    Publication date: March 22, 2012
    Applicant: Millipore Corporation
    Inventors: Martin Zillmann, Jad Jaber, James Hamzik
  • Patent number: 8129120
    Abstract: Methods for determining genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information.
    Type: Grant
    Filed: February 28, 2007
    Date of Patent: March 6, 2012
    Assignee: Sequenom, Inc.
    Inventors: Jeffrey Olson, Martin Zillmann, Vincent P. Stanton, Jr.
  • Patent number: 7435541
    Abstract: Methods for determining genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information.
    Type: Grant
    Filed: April 4, 2002
    Date of Patent: October 14, 2008
    Assignee: Sequenom, Inc.
    Inventors: Jeffrey Olson, Martin Zillmann, Vincent P. Stanton, Jr.
  • Publication number: 20080206748
    Abstract: Methods for determining genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information.
    Type: Application
    Filed: February 28, 2007
    Publication date: August 28, 2008
    Inventors: Jeffrey Olson, Martin Zillmann, Vincent P. Stanton
  • Publication number: 20070031853
    Abstract: The present disclosure describes the use of genetic variance information for genes involved in neurologic and phychiatric diseases and in the selection of effective methods of treatment of such disease or condition. The variance information is indicative of the expected response of a patient to a method of treatment. Methods of determining relevant variance information and additional methods of using such variance information are also described.
    Type: Application
    Filed: May 2, 2005
    Publication date: February 8, 2007
    Inventors: Vincent Stanton, Martin Zillmann
  • Publication number: 20050200250
    Abstract: Furniture connectors and modular furniture systems are disclosed. The furniture connectors can be configured to include furniture-engaging portions of the connectors that are inserted into grooves that extend along edges of furniture members. The connectors can include at least two furniture-engaging portions that may be fastened to multiple furniture members to connect furniture members together in a secure manner in a variety of assembly configurations. The modular furniture systems disclosed may use easy-to-assemble connectors and reversible connections that may permit disassembly and reassembly, optionally, into a different furniture configuration than the one disassembled.
    Type: Application
    Filed: March 9, 2004
    Publication date: September 15, 2005
    Inventors: Dolf Zillmann, Martin Zillmann
  • Patent number: 6777188
    Abstract: The present invention relates to a method for genotyping a diploid organism by cleaving segments of two alleles such that 7-20 nucleotide fragments that contain a suspected polymorphic locus are produced and comparing the masses of those fragments.
    Type: Grant
    Filed: March 26, 2002
    Date of Patent: August 17, 2004
    Assignee: Variagenics, Inc.
    Inventors: Vincent P. Stanton, Jr., Jeffrey Olson, Jia Liu Wolfe, Martin Zillmann
  • Publication number: 20030219769
    Abstract: Methods for determing genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information.
    Type: Application
    Filed: November 5, 2002
    Publication date: November 27, 2003
    Applicant: Variagenics, Inc. a Delaware corporation
    Inventors: Jeffrey Olson, Martin Zillmann, Vincent P. Stanton
  • Patent number: 6608230
    Abstract: A single-stage method for producing &agr;-hydroxy ethers by oxidizing olefinic substrates with organic hydroperoxides and opening the resultant oxirane ring by means of monovalent or polyvalent alcohols wherein a molybdenum compound in combination with a compound selected from the group consisting of boron trifluoride, aluminum oxides, 1,8-diazabicyclo-[5.4.0]-undec-7-ene or 1,4-diazabicyclo-[2.2.2]-octane, and mixtures thereof is used as a catalyst system.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: August 19, 2003
    Assignee: WE-DEA Aktiengesellschaft für Mineraloel und Chemie
    Inventors: Mark Rüsch gen. Klaas, Siegfried Warwel, Hans-Martin Zillmann, Klaus Kwetkat
  • Publication number: 20030073101
    Abstract: Methods for determing genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information.
    Type: Application
    Filed: April 4, 2002
    Publication date: April 17, 2003
    Inventors: Jeffrey Olson, Martin Zillmann, Vincent P. Stanton
  • Publication number: 20020150943
    Abstract: The present invention relates to a method for genotyping a diploid organism by cleaving segments of two alleles such that 7-20 nucleotide fragments that contain a suspected polymorphic locus are produced and comparing the masses of those fragments.
    Type: Application
    Filed: March 26, 2002
    Publication date: October 17, 2002
    Applicant: Variagenics, Inc.
    Inventors: Vincent P. Stanton, Jeffrey Olson, Jia Liu Wolfe, Martin Zillmann