Patents by Inventor Martina Junius
Martina Junius has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7541448Abstract: The invention is directed to an oligonucleotide comprising a molecular rod, wherein preferentially the molecular rod covalently connects the 3? end of a first nucleotide residue with the 5? end of a second nucleotide residue. Such oligonucleotides are highly advantageous for real time PCR melting curve analysis.Type: GrantFiled: December 2, 2004Date of Patent: June 2, 2009Assignee: Roche Diagnostis Operations, Inc.Inventors: Dieter Heindl, Astrid Reiser, Karim Tabiti, Martina Junius, Alexander Hauber
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Publication number: 20050142598Abstract: The invention is directed to an oligonucleotide comprising a molecular rod, wherein preferentially the molecular rod covalently connects the 3? end of a first nucleotide residue with the 5? end of a second nucleotide residue. Such oligonucleotides are highly advantageous for real time PCR melting curve analysis.Type: ApplicationFiled: December 2, 2004Publication date: June 30, 2005Inventors: Dieter Heindl, Astrid Reiser, Karim Tabiti, Martina Junius, Alexander Hauber
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Patent number: 6057120Abstract: The invention concerns the use of redox-active compounds for the production of detection reagents for a method for the determination of an analyte as well as reagent kits that contain these redox-active compounds. In addition new redox-active compounds are disclosed.Type: GrantFiled: September 22, 1997Date of Patent: May 2, 2000Assignee: Roche Diagnostics GmbHInventors: Dieter Heindl, Rupert Herrmann, Joachim Hones, Hans-Peter Josel, Martina Junius-Comer, Hartmut Merdes, Axel Schmidt, Ernst Selbertinger
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Patent number: 5854073Abstract: The invention concerns a stable control serum or calibration serum containing bilirubin to analytically examine the methodical accuracy of individual parameters in human sera or patients. The control serum or calibration serum according to the invention is used to stabilize bilirubin in solutions and to generally increase the stability of control sera or calibration sera.Type: GrantFiled: March 21, 1997Date of Patent: December 29, 1998Assignee: Bohringer Mannheim GmbHInventors: Geoffrey Burns, Martina Junius-Comer
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Patent number: 5654163Abstract: The invention concerns new indophenyl-substituted maltose derivatives, their use for the determination of the enzymatic activity of .alpha.-amylase and reagents for the determination of .alpha.-amylase which contain the new indophenyl-substituted maltose derivatives as the enzyme substrate.Type: GrantFiled: July 24, 1995Date of Patent: August 5, 1997Assignee: Boehringer Mannheim GmbHInventors: Martina Junius-Comer, Axel Schmidt, Elli Rauscher
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Patent number: 5244789Abstract: The present invention provides a process for the determination of phospholipase A in body fluids, wherein the body fluid is incubated with a mixture containing a substrate having a fatty acid residue for the phospholipase and at least two emulsifiers of different chemical classes, namely, at least one neutral emulsifier and a bile acid salt, and the amount of the free fatty acids formed by the cleavage of the substrate is determined in known manner.Type: GrantFiled: September 9, 1991Date of Patent: September 14, 1993Assignee: Boehringer Mannheim GmbHInventors: Ulrich Neumann, Gudrun Schmidt, Martina Junius-Comer
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Patent number: 5204242Abstract: The present invention provides a colorimetric process for the detection of an oxidative coupling reaction in which a coupling component is reacted with a developer component in the presence of an oxidation agent to give a colored material, wherein, as coupling component, there is used a compound of the general formula: ##STR1## in which X is a bromine or chlorine atom, n is 1, 2 or 3, Y is COOR, CONRR', SO.sub.3 R, SO.sub.2 NRR', OR, NRR' or NRR'R".sym. and R, R' and R", independently of one another, are hydrogen atoms or C.sub.1 -C.sub.3 -alkyl radicals.The present invention also provides a reagent which contains the above compound, as well as new substituted phenols and a process for the preparation thereof.Type: GrantFiled: September 17, 1991Date of Patent: April 20, 1993Assignee: Boehringer Mannheim GmbHInventors: Martina Junius-Comer, Bernd Vogt, Rupert Herrmann
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Patent number: 5194382Abstract: In order to increase the enzymatic reactivity of .beta.-galactosidase, an azide, thiocyanate, cyanate and/or thiosulphate is added to the reaction mixture.Type: GrantFiled: November 5, 1990Date of Patent: March 16, 1993Assignee: Boehringer Mannheim GmbHInventors: Rupert Herrmann, Hans-Joachim Guder, Martina Junius-Comer
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Patent number: 5091527Abstract: The present invention provides phospholipase substrates of the general formula: ##STR1## wherein A is an alkylene or alkenylene radical containing up to 16 carbon atoms, R is a hydrgen atom or an alkyl, alkenyl or acyl radical containing up to 20 carbon atoms or an optionally alkyl-substituted aryl or aralkyl radical containing up to 8 carbon atoms in the alkyl moiety, X is the residue of an aromatic hydroxy or thiol compound and each Y, independently of one another, is an oxygen or sulphur atom and Z is --SO.sub.3.sup..crclbar. or a radical of the general formula: ##STR2## wherein R.sup.1 can be a hydrogen atom or a radical of the general formula --(CH.sub.2).sub.n NR.sub.3.sup.2, in which n is 2, 3 or 4 and R.sup.2 is a hydrogen atom or a methyl radical, or is an inositol or serine (--CH.sub.2 --CH(NH.sub.2)--COOH) or glycerol residue.The present invention also provides a process for the optical determination of phospholipases using these substrates, as well as a reagent containing them.Type: GrantFiled: March 2, 1989Date of Patent: February 25, 1992Assignee: Boehringer Mannheim GmbHInventors: Martina Junius, Ulrich Neumann, Herbert von der Eltz
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Patent number: 4988497Abstract: The present invention provides a lipase substrate of the general formula: ##STR1## wherein A is an alkalene or alkenylene radical containing up to 16 carbon atoms, R and R.sub.1, which can be the same or different, each signify an alkyl, alkenyl or acyl radical containing up to 20 carbon atoms or an optionally alkyl-substituted aryl or aralkyl radical containing up to 8 carbon atoms in the alkyl moiety and wherein one of R and R.sub.1 can also be a hydrogen atom, X is the residue of an aromatic hydroxy or thiol compound, and each Y and Z, independently from each other, is --S-- or --O--, Z also --CH.sub.2 --.The present invention also provides a process and a reagent for the optical determination of lipase.Type: GrantFiled: May 17, 1989Date of Patent: January 29, 1991Assignee: Boehringer Mannheim GmbHInventors: Ulrich Neumann, Martina Junius, Hans-Georg Batz
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Patent number: 4847376Abstract: The present invention provides a lipase substrate of the general formula: ##STR1## wherein A is an alkylene or alkenylene radical containing up to 16 carbon atoms, R and R.sub.1, which can be the same or different, each signify an alkyl, alkenyl or acyl radical containing up to 20 carbon atoms or an optionally alkyl-substituted aryl or aralkyl radical containing up to 8 carbon atoms in the alkyl moiety and wherein one of R and R.sub.1 can also be a hydrogen atom, X is the residue of an aromatic hydroxy or thiol compound, and each Y and Z, independently from each other, is --S-- or --O--, Z also --CH.sub.2 --.The present invention also provides a process and a reagent for the optical determination of lipase.Type: GrantFiled: May 1, 1986Date of Patent: July 11, 1989Assignee: Boehringer Mannheim GmbHInventors: Ulrich Neumann, Martina Junius, Hans-Georg Batz
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Patent number: 4786591Abstract: The present invention provides a process for determining the binding capacity of thyroxin-binding globulin (TBG) according to the principle of heterogeneous enzyme immunoassay, wherein the serum sample to be investigated is incubated with enzyme-labelled T.sub.4 or T.sub.3 and immobilized antibody against TBG or T.sub.4, the phase are separated and the labelling enzyme is measured in one of the phases.Type: GrantFiled: December 23, 1986Date of Patent: November 22, 1988Assignee: Boehringer Mannheim GmbHInventors: Brigitte Draeger, Winfried Albert, Martina Junius, Jurgen Rasch
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Patent number: 4737466Abstract: The present invention provides N-acylidihydroresorufin derivatives of the general formula: ##STR1## wherein R.sup.1 is a lower alkyl, aryl or aralkyl radical, which can be substituted by carboxyl or sulphonic acid residues, R.sup.2, R.sup.3 and R.sup.4, which can be the same or different, are hydrogen or halogen atoms or lower alkyl or lower alkoxy radicals, Y is an --NR.sup.5 R.sup.6 or --OR.sup.7 group, wherein R.sup.5 and R.sup.6 are, in each case, hydrogen atoms or lower alkyl radicals, which can be substituted by carboxyl or sulphonic acid residues, or together represent a hydrocarbon bridge optionally interrupted by hereto atoms and R.sup.7 is a lower alkyl radical which can be substituted by a lower alkoxy or poly-lower alkoxy radical.Type: GrantFiled: July 11, 1986Date of Patent: April 12, 1988Assignee: Boehringer Mannheim GmbHInventors: Christian Klein, Herbert Von Der Eltz, Rupert Herrmann, Martina Junius