Patents by Inventor Martina Ochs

Martina Ochs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PERTUSSIS BOOSTER VACCINE
    Publication number: 20220054615
    Abstract: The present disclosure is directed to a modified acellular pertussis booster vaccine comprising a TLR agonist and methods of using the same for inducing an immune response.
    Type: Application
    Filed: November 29, 2019
    Publication date: February 24, 2022
    Inventors: Nicolas BURDIN, Martina OCHS, Marie GARINOT, Martine CHABAUD-RIOU, Nathalie REVENEAU, Yuanqing LIU, Noelle MISTRETTA
  • Composition for Immunization Against Streptococcus Pneumoniae
    Publication number: 20190071471
    Abstract: This disclosure relates to a method of preventing or treating a recurrence of acute otitis media in a subject at risk comprising administering a therapeutically effective amount of a composition, at least once to the subject.
    Type: Application
    Filed: April 16, 2018
    Publication date: March 7, 2019
    Inventors: Michael Pichichero, Martina Ochs-Onolemhemhen
  • Composition for immunization against
    Patent number: 9944680
    Abstract: This disclosure relates to a method of preventing or treating a recurrence of acute otitis media in a subject at risk comprising administering a therapeutically effective amount of a composition, at least once to the subject. The composition administered comprises at least one immunogenic polypeptide selected from the group consisting of Streptococcus pneumoniae PhtD, PhtE, PcpA, LytB and detoxified pneumolysin.
    Type: Grant
    Filed: December 2, 2011
    Date of Patent: April 17, 2018
    Assignee: SANDFI PASTEUR LIMITED
    Inventors: Michael Pichichero, Martina Ochs-Onolemhemhen
  • Immunogenic Compositions
    Publication number: 20170157233
    Abstract: This disclosure relates to immunogenic compositions comprising an isolated immunogenic S. pneumoniae PcpA polypeptide, at least one additional antigen (such as for example, an isolated immunogenic S. pneumoniae polypeptide selected from the group consisting of the polyhistidine triad family of proteins (e.g., PhtD), and at least one isolated detoxified pneumolysin (e.g., PlyD1) and methods of using these compositions for preventing and treating diseases caused by S. pneumoniae.
    Type: Application
    Filed: March 10, 2015
    Publication date: June 8, 2017
    Applicant: Sanofi Pasteur Limited
    Inventors: Scott Gallichan, Belma Ljutic, Martina Ochs-Onolemhemhen, Marie-Danielle Salha, Robert Hopfer, Lee-Jah Chang
  • Immunogenic compositions and related methods
    Patent number: 9649372
    Abstract: This disclosure relates to adjuvants for use in immunogenic compositions comprising at least one antigen and an aluminum compound comprising hydroxyl groups that has been treated with phosphate, carboxylate, carbonate, sulfate diphosphonate or a mixture of two or more of these compounds and methods of using these compositions for preventing and treating diseases are also provided.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: May 16, 2017
    Assignee: SANOFI PASTEUR LIMITED
    Inventors: Kevin Harper, Belma Ljutic, Scott Gallichan, Martina Ochs-Onolemhemhen, Garry Morefield, Fernando Ausar, Marie-Danielle Salha
  • Assay for Diagnosing Streptococcus Pneumoniae
    Publication number: 20170102385
    Abstract: Assays for detecting anti-streptococcal antibodies in biological samples using one or more streptococcal antigens are described herein. Various combinations of antigens may be used in the assays. For example, one or more of Ply, PhtD, PhtE, LytB and PcpA may be utilized. Additional streptococcal antigens may also be used. The assays may also be used in combination with assays that detect streptococcal nucleic acids.
    Type: Application
    Filed: December 19, 2016
    Publication date: April 13, 2017
    Applicant: Sanofi Pasteur Limited
    Inventors: Martina Ochs-Onolemhemhen, Roger Brookes, Claire-Anne Siegrest
  • Modified pneumolysin (PLY) polypeptides
    Patent number: 9546199
    Abstract: This disclosure relates to immunogenic compositions comprising mutant Streptococcus pneumonia pneumolysin (PLY) proteins. Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: January 17, 2017
    Assignee: The Kingdom of The Netherlands, Represented by The Minister of Health, Welfare and Sport, On Behalf of The Minister, The National Institute of Public Health and The Environment
    Inventors: Eliud Oloo, Raymond Oomen, Martina Ochs-Onolemhemhen, Jeremy Yethon
  • Assay for diagnosing
    Patent number: 9535064
    Abstract: Assays for detecting anti-streptococcal antibodies in biological samples using one or more streptococcal antigens are described herein. Various combinations of antigens may be used in the assays. For example, one or more of Ply, PhtD, PhtE, LytB and PcpA may be utilized. Additional streptococcal antigens may also be used. The assays may also be used in combination with assays that detect streptococcal nucleic acids.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: January 3, 2017
    Assignee: SANOFI PASTEUR LIMITED
    Inventors: Martina Ochs-Onolemhemhen, Roger Brookes, Claire-Anne Siegrest
  • Immunogenic Polypeptides and Monoclonal Antibodies
    Publication number: 20160228500
    Abstract: Provided herein are compositions and methods for eliciting an immune response against Streptococcus pneumoniae. More particularly, the compositions and methods relate to immunogenic polypeptides, including fragments of PhtD and variants thereof, and nucleic acids, vectors and transfected cells that encode or express the polypeptides. Methods of making and using the immunogenic polypeptides are also described.
    Type: Application
    Filed: July 23, 2012
    Publication date: August 11, 2016
    Inventors: Martina Ochs, Roger Brooks, Robert Charlebois, Jeremy Yethon
  • Modified Streptococcus Pneumoniae Pneumolysin (PLY) Polypeptides
    Publication number: 20150376242
    Abstract: This disclosure relates to immunogenic compositions comprising mutant Streptococcus pneumonia pneumolysin (PLY) proteins. Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided.
    Type: Application
    Filed: December 18, 2014
    Publication date: December 31, 2015
    Inventors: Eliud Oloo, Raymond Oomen, Martina Ochs, Jeremy Yethon
  • METHODS FOR ASSESSING IMMUNOGENICITY
    Publication number: 20150316567
    Abstract: This disclosure relates to methods for detecting the potency of a drug preparation and/or detecting antibodies in a host reactive against one or more antigens.
    Type: Application
    Filed: December 13, 2014
    Publication date: November 5, 2015
    Applicant: SANOFI PASTEUR LIMITED
    Inventors: Marie-Danielle Salha, Scott Gallichan, Roger Brookes, Martina Ochs-Onolemhemhen
  • Modified pneumonia pneumolysin (PLY) polypeptides
    Patent number: 8951531
    Abstract: This disclosure relates to modified Streptococcus pneumonia pneumolysm (PLY) proteins which lack hemolytic activity and can be used as immunogens in an immunogenic composition or vaccine against invasive pneumococcol diseases caused by S. pneumonia The modified pneumolysm proteins comprise amino acid substitutions at threonine 65, glycine 293 and cysteine 428 Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: February 10, 2015
    Assignee: The Kingdom of the Netherlands, Represented by the Minister of Health, Welfare and Sport, on Behalf of the Minister, The National Institute of Public Health and the Environment
    Inventors: Eliud Oloo, Raymond Oomen, Martina Ochs-Onolemhemhen, Jeremy Yethon
  • Assay for Diagnosing Streptococcus Pneumoniae
    Publication number: 20140349863
    Abstract: Assays for detecting anti-streptococcal antibodies in biological samples using one or more streptococcal antigens are described herein. Various combinations of antigens may be used in the assays. For example, one or more of Ply, PhtD, PhtE, LytB and PcpA may be utilized. Additional streptococcal antigens may also be used. The assays may also be used in combination with assays that detect streptococcal nucleic acids.
    Type: Application
    Filed: March 1, 2013
    Publication date: November 27, 2014
    Applicant: Sanofi Pasteur Limited
    Inventors: Martina Ochs-Onolemhemhen, Roger Brookes, Claire-Anne Siegrest
  • Modified Streptococcus Pneumonia Pneumolysin (PLY) Polypeptides
    Publication number: 20140341942
    Abstract: This disclosure relates to modified Streptococcus pneumonia pneumolysm (PLY) proteins which lack hemolytic activity and can be used as immunogens in an immunogenic composition or vaccine against invasive pneumococcol diseases caused by S.
    Type: Application
    Filed: May 5, 2014
    Publication date: November 20, 2014
    Inventors: Eliud Oloo, Raymond Oomen, Martina Ochs, Jeremy Yethon
  • Modified pneumolysin (PLY) polypeptides
    Patent number: 8758766
    Abstract: This disclosure relates to modified Streptococcus pneumonia pneumolysm (PLY) proteins which lack hemolytic activity and can be used as immunogens in an immunogenic composition or vaccine against invasive pneumococcol diseases caused by S. pneumonia. The modified pneumolysm proteins comprise ammo acid substitutions at threonine 65, glycine 293 and cysteine 428 Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: June 24, 2014
    Assignee: The Kingdom of The Netherlands, Represented by The Mininster of Health, Welfare and Sport, on Behalf of The Minster The National Institute of Public Health and The Environment
    Inventors: Eliud Oloo, Raymond Oomen, Martina Ochs, Jeremy Yethon
  • IMMUNOGENIC COMPOSITIONS
    Publication number: 20130183350
    Abstract: This disclosure relates to immunogenic compositions comprising an isolated immunogenic S. pneumoniae PcpA polypeptide and at least one additional antigen (such as for example, an isolated immunogenic S. pneumoniae polypeptide selected from the group consisting of the polyhistidine triad family of proteins (e.g. PhtD) and methods of using these compositions for preventing and treating diseases caused by S. pneumoniae.
    Type: Application
    Filed: December 20, 2010
    Publication date: July 18, 2013
    Inventors: Kevin Harper, Belma Ljutic, Scott Gallichan, Martina Ochs-Onolemhemhen, Garry Morefield, Fernando Ausar, Marie-Danielle Salha
  • Immunogenic Polypeptides and Monoclonal Antibodies
    Publication number: 20130184200
    Abstract: Provided herein are compositions and methods for eliciting an immune response against Streptococcus pneumoniae. More particularly, the compositions and methods relate to immunogenic polypeptides, including fragments of PhtD and variants thereof, and nucleic acids, vectors and transfected cells that encode or express the polypeptides. Methods of making and using the immunogenic polypeptides are also described.
    Type: Application
    Filed: July 23, 2012
    Publication date: July 18, 2013
    Inventors: Martina Ochs, Roger Brooks, Robert Charlebois, Jeremy Yethon
  • Assay for diagnosing
    Patent number: 8404457
    Abstract: Assays for detecting anti-streptococcal antibodies in biological samples using one or more streptococcal antigens are described herein. Various combinations of antigens may be used in the assays. For example, one or more of Ply, PhtD, PhtE, LytB and PcpA may be utilized. Additional streptococcal antigens may also be used. The assays may also be used in combination with assays that detect streptococcal nucleic acids.
    Type: Grant
    Filed: February 2, 2009
    Date of Patent: March 26, 2013
    Assignee: Sanofi Pasteur Limited
    Inventors: Martina Ochs-Onolemhemhen, Roger Brookes, Claire-Anne Siegrist
  • IMMUNOGENIC COMPOSITIONS AND RELATED METHODS
    Publication number: 20130034579
    Abstract: This disclosure relates to adjuvants for use in immunogenic compositions comprising at least one antigen and an aluminum compound comprising hydroxyl groups that has been treated with phosphate, carboxylate, carbonate, sulfate diphosphonate or a mixture of two or more of these compounds and methods of using these compositions for preventing and treating diseases are also provided.
    Type: Application
    Filed: December 20, 2010
    Publication date: February 7, 2013
    Inventors: Kevin Harper, Belma Ljutic, Scott Gallichan, Martina Ochs-Onolemhemhen, Garry Morefield, Fernando Ausar, Marie-Danielle Salha
  • Immunogenic polypeptides and monoclonal antibodies
    Patent number: 8337846
    Abstract: Provided herein are compositions and methods for eliciting an immune response against Streptococcus pneumoniae. More particularly, the compositions and methods relate to immunogenic polypeptides, including fragments of PhtD and variants thereof, and nucleic acids, vectors and transfected cells that encode or express the polypeptides. Methods of making and using the immunogenic polypeptides are also described.
    Type: Grant
    Filed: July 23, 2008
    Date of Patent: December 25, 2012
    Assignee: Sanofi Pasteur Limited
    Inventors: Martina Ochs, Roger Brookes, Robert Charlebois, Jeremy Yethon