Patents by Inventor Martina Ochs-Onolemhemhen
Martina Ochs-Onolemhemhen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190071471Abstract: This disclosure relates to a method of preventing or treating a recurrence of acute otitis media in a subject at risk comprising administering a therapeutically effective amount of a composition, at least once to the subject.Type: ApplicationFiled: April 16, 2018Publication date: March 7, 2019Inventors: Michael Pichichero, Martina Ochs-Onolemhemhen
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Patent number: 9944680Abstract: This disclosure relates to a method of preventing or treating a recurrence of acute otitis media in a subject at risk comprising administering a therapeutically effective amount of a composition, at least once to the subject. The composition administered comprises at least one immunogenic polypeptide selected from the group consisting of Streptococcus pneumoniae PhtD, PhtE, PcpA, LytB and detoxified pneumolysin.Type: GrantFiled: December 2, 2011Date of Patent: April 17, 2018Assignee: SANDFI PASTEUR LIMITEDInventors: Michael Pichichero, Martina Ochs-Onolemhemhen
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Publication number: 20170157233Abstract: This disclosure relates to immunogenic compositions comprising an isolated immunogenic S. pneumoniae PcpA polypeptide, at least one additional antigen (such as for example, an isolated immunogenic S. pneumoniae polypeptide selected from the group consisting of the polyhistidine triad family of proteins (e.g., PhtD), and at least one isolated detoxified pneumolysin (e.g., PlyD1) and methods of using these compositions for preventing and treating diseases caused by S. pneumoniae.Type: ApplicationFiled: March 10, 2015Publication date: June 8, 2017Applicant: Sanofi Pasteur LimitedInventors: Scott Gallichan, Belma Ljutic, Martina Ochs-Onolemhemhen, Marie-Danielle Salha, Robert Hopfer, Lee-Jah Chang
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Patent number: 9649372Abstract: This disclosure relates to adjuvants for use in immunogenic compositions comprising at least one antigen and an aluminum compound comprising hydroxyl groups that has been treated with phosphate, carboxylate, carbonate, sulfate diphosphonate or a mixture of two or more of these compounds and methods of using these compositions for preventing and treating diseases are also provided.Type: GrantFiled: December 20, 2010Date of Patent: May 16, 2017Assignee: SANOFI PASTEUR LIMITEDInventors: Kevin Harper, Belma Ljutic, Scott Gallichan, Martina Ochs-Onolemhemhen, Garry Morefield, Fernando Ausar, Marie-Danielle Salha
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Publication number: 20170102385Abstract: Assays for detecting anti-streptococcal antibodies in biological samples using one or more streptococcal antigens are described herein. Various combinations of antigens may be used in the assays. For example, one or more of Ply, PhtD, PhtE, LytB and PcpA may be utilized. Additional streptococcal antigens may also be used. The assays may also be used in combination with assays that detect streptococcal nucleic acids.Type: ApplicationFiled: December 19, 2016Publication date: April 13, 2017Applicant: Sanofi Pasteur LimitedInventors: Martina Ochs-Onolemhemhen, Roger Brookes, Claire-Anne Siegrest
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Patent number: 9546199Abstract: This disclosure relates to immunogenic compositions comprising mutant Streptococcus pneumonia pneumolysin (PLY) proteins. Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided.Type: GrantFiled: December 18, 2014Date of Patent: January 17, 2017Assignee: The Kingdom of The Netherlands, Represented by The Minister of Health, Welfare and Sport, On Behalf of The Minister, The National Institute of Public Health and The EnvironmentInventors: Eliud Oloo, Raymond Oomen, Martina Ochs-Onolemhemhen, Jeremy Yethon
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Patent number: 9535064Abstract: Assays for detecting anti-streptococcal antibodies in biological samples using one or more streptococcal antigens are described herein. Various combinations of antigens may be used in the assays. For example, one or more of Ply, PhtD, PhtE, LytB and PcpA may be utilized. Additional streptococcal antigens may also be used. The assays may also be used in combination with assays that detect streptococcal nucleic acids.Type: GrantFiled: March 1, 2013Date of Patent: January 3, 2017Assignee: SANOFI PASTEUR LIMITEDInventors: Martina Ochs-Onolemhemhen, Roger Brookes, Claire-Anne Siegrest
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Publication number: 20150316567Abstract: This disclosure relates to methods for detecting the potency of a drug preparation and/or detecting antibodies in a host reactive against one or more antigens.Type: ApplicationFiled: December 13, 2014Publication date: November 5, 2015Applicant: SANOFI PASTEUR LIMITEDInventors: Marie-Danielle Salha, Scott Gallichan, Roger Brookes, Martina Ochs-Onolemhemhen
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Patent number: 8951531Abstract: This disclosure relates to modified Streptococcus pneumonia pneumolysm (PLY) proteins which lack hemolytic activity and can be used as immunogens in an immunogenic composition or vaccine against invasive pneumococcol diseases caused by S. pneumonia The modified pneumolysm proteins comprise amino acid substitutions at threonine 65, glycine 293 and cysteine 428 Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided.Type: GrantFiled: May 5, 2014Date of Patent: February 10, 2015Assignee: The Kingdom of the Netherlands, Represented by the Minister of Health, Welfare and Sport, on Behalf of the Minister, The National Institute of Public Health and the EnvironmentInventors: Eliud Oloo, Raymond Oomen, Martina Ochs-Onolemhemhen, Jeremy Yethon
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Publication number: 20140349863Abstract: Assays for detecting anti-streptococcal antibodies in biological samples using one or more streptococcal antigens are described herein. Various combinations of antigens may be used in the assays. For example, one or more of Ply, PhtD, PhtE, LytB and PcpA may be utilized. Additional streptococcal antigens may also be used. The assays may also be used in combination with assays that detect streptococcal nucleic acids.Type: ApplicationFiled: March 1, 2013Publication date: November 27, 2014Applicant: Sanofi Pasteur LimitedInventors: Martina Ochs-Onolemhemhen, Roger Brookes, Claire-Anne Siegrest
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Publication number: 20130183350Abstract: This disclosure relates to immunogenic compositions comprising an isolated immunogenic S. pneumoniae PcpA polypeptide and at least one additional antigen (such as for example, an isolated immunogenic S. pneumoniae polypeptide selected from the group consisting of the polyhistidine triad family of proteins (e.g. PhtD) and methods of using these compositions for preventing and treating diseases caused by S. pneumoniae.Type: ApplicationFiled: December 20, 2010Publication date: July 18, 2013Inventors: Kevin Harper, Belma Ljutic, Scott Gallichan, Martina Ochs-Onolemhemhen, Garry Morefield, Fernando Ausar, Marie-Danielle Salha
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Patent number: 8404457Abstract: Assays for detecting anti-streptococcal antibodies in biological samples using one or more streptococcal antigens are described herein. Various combinations of antigens may be used in the assays. For example, one or more of Ply, PhtD, PhtE, LytB and PcpA may be utilized. Additional streptococcal antigens may also be used. The assays may also be used in combination with assays that detect streptococcal nucleic acids.Type: GrantFiled: February 2, 2009Date of Patent: March 26, 2013Assignee: Sanofi Pasteur LimitedInventors: Martina Ochs-Onolemhemhen, Roger Brookes, Claire-Anne Siegrist
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Publication number: 20130034579Abstract: This disclosure relates to adjuvants for use in immunogenic compositions comprising at least one antigen and an aluminum compound comprising hydroxyl groups that has been treated with phosphate, carboxylate, carbonate, sulfate diphosphonate or a mixture of two or more of these compounds and methods of using these compositions for preventing and treating diseases are also provided.Type: ApplicationFiled: December 20, 2010Publication date: February 7, 2013Inventors: Kevin Harper, Belma Ljutic, Scott Gallichan, Martina Ochs-Onolemhemhen, Garry Morefield, Fernando Ausar, Marie-Danielle Salha
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Publication number: 20110130300Abstract: Assays for detecting anti-streptococcal antibodies in biological samples using one or more streptococcal antigens are described herein. Various combinations of antigens may be used in the assays. For example, one or more of Ply, PhtD, PhtE, LytB and PcpA may be utilized. Additional streptococcal antigens may also be used. The assays may also be used in combination with assays that detect streptococcal nucleic acids.Type: ApplicationFiled: February 2, 2008Publication date: June 2, 2011Inventors: Martina Ochs-Onolemhemhen, Roger Brookes, Claire-Anne Siegrest