Patents by Inventor Martina Schäfer

Martina Schäfer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED PHENYLALANINE DERIVATIVES
    Publication number: 20160222056
    Abstract: The invention relates to substituted phenylalanine derivatives and to processes for preparation thereof, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders and/or severe perioperative blood loss.
    Type: Application
    Filed: September 24, 2014
    Publication date: August 4, 2016
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Ulrike RÖHN, Manuel ELLERMANN, Julia STRASSBURGER, Astrid WENDT, Susanne RÖHRIG, Robert Alan WEBSTER, Martina Victoria SCHMIDT, Adrian TERSTEEGEN, Kristin BEYER, Martina SCHÄFER, Anja BUCHMÜLLER, Christoph GERDES, Michael SPERZEL, Steffen SANDMANN, Stefan HEITMEIER, Alexander HILLISCH, Jens ACKERSTAFF, Carsten TERJUNG
  • SUBSTITUTED OXOPYRIDINE DERIVATIVES AND USE THEREOF AS FACTOR XIA/PLASMA
    Publication number: 20160152613
    Abstract: The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
    Type: Application
    Filed: July 21, 2014
    Publication date: June 2, 2016
    Inventors: Susanne RÖHRIG, Alexander HILLISCH, Julia STRAßBURGER, Stefan HEITMEIER, Martina Victoria SCHMIDT, Karl-Heinz SCHLEMMER, Anja BUCHMÜLLER, Christoph GERDES, Henrik TELLER, Martina SCHÄFER, Adrian TERSTEEGEN
  • Substituted Oxopyridine Derivatives and Use Thereof in the Treatment of Cardiovascular Disorders
    Publication number: 20160052884
    Abstract: The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
    Type: Application
    Filed: March 27, 2014
    Publication date: February 25, 2016
    Inventors: Susanne RÖHRIG, Alexander HILLISCH, Julia STRAßBURGER, Stefan HEITMEIER, Martina Victoria SCHMIDT, Karl-Heinz SCHLEMMER, Adrian TERSTEEGEN, Anja BUCHMÜLLER, Christoph GERDES, Martina SCHÄFER, Tom KINZEL, Henrik TELLER, Hartmut SCHIROK, Jürgen KLAR, Eloisa JIMENEZ NUNEZ
  • BICYCLICALLY SUBSTITUTED URACILS AND THE USE THEREOF
    Publication number: 20150148340
    Abstract: The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
    Type: Application
    Filed: May 3, 2013
    Publication date: May 28, 2015
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Chantal Fürstner, Jens Ackerstaff, Alexander Straub, Heinrich Meier, Hanna Tinel, Katja Zimmermann, Adrian Tersteegen, Dmitry Zubov, Raimund Kast, Jens Schamberger, Martina Schäfer, Kirsten Börngen
  • Antibodies capable of binding to the coagulation Factor XI and/or its activated form factor XIa and uses thereof
    Publication number: 20150099298
    Abstract: The present invention relates to antibodies capable of binding to the coagulation Factor XI and/or its activated form factor XIa and methods of use thereof, particularly methods of use as agents inhibiting platelet aggregation and by this inhibits thrombus formation.
    Type: Application
    Filed: May 8, 2013
    Publication date: April 9, 2015
    Inventors: Andreas Wilmen, Julia Straßburger, Frank Dittmer, Michael Strerath, Anja Buchmüller, Joanna Grudzinska-Goebel, Ricarda Finnern, Martina Schäfer, Christoph Gerdes, Hannah Jörißen, Asako Itakura, Philberta Leung, Erik Tucker
  • BINDING PROTEINS TO INHIBITORS OF COAGULATION FACTORS
    Publication number: 20140050743
    Abstract: The present invention relates to the identification and use of antigen-binding regions, antibodies, antigen-binding antibody fragments and antibody mimetics, neutralizing the anti-coagulant effect of an anticoagulant in vitro and/or in vivo. Antibodies and functional fragments of the invention and antibody mimetics can be used to specifically reverse the pharmacological effect of an anticoagulant e.g. a FXa inhibitor for therapeutic (antidote) and/or diagnostic purposes. The invention also provides nucleic acid sequences encoding foregoing molecules, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
    Type: Application
    Filed: January 17, 2012
    Publication date: February 20, 2014
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Frank Dittmer, Anja Buchmüller, Christoph Gerdes, Adrian Tersteegen, Mark Jean Gnoth, Lars Linden, Axel Harrenga, Joanna Grudzinska-Goebel, Mario Jeske, Martina Schäfer, Jörg Birkenfeld, Holger Paulsen, Ricarda Finnern, Anke Mayer-Bartschmid, Andrea Eicker, Simone Greven, Susanne Steinig
  • Sulphoximine-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments
    Patent number: 7863283
    Abstract: The present invention relates to sulphoximine-substituted quinazoline derivatives of the formula (I), processes for their preparation and their use as a medicament for the treatment of various diseases.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: January 4, 2011
    Assignee: Bayer Schering Pharma AG
    Inventors: Duy Nguyen, Arne von Bonin, Michael Haerter, Hartmut Schirok, Anne Mengel, Martina Schaefer, Oliver von Ahsen
  • Pyrazolopyridines and salts thereof, a pharmaceutical composition comprising said compounds, a method of preparing same and use of same
    Patent number: 7842809
    Abstract: The invention relates to pyrazolopyridines according to the general formula (I): and salts thereof, to pharmaceutical compositions comprising said pyrazolopyridines and to a method of preparing said pyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with angiopoietin and therefore influence Tie2 signalling.
    Type: Grant
    Filed: January 23, 2006
    Date of Patent: November 30, 2010
    Assignee: Bayer Schering Pharma AG
    Inventors: Wolfgang Schwede, Hans Briem, Hermann Kuenzer, Manfred Husemann, Georg Kettschau, Martina Schaefer, Antonius Ter Laak, Karl-Heinz Thierauch, Stuart James Ince
  • CDK-inhibitory pyrimidines, their production and use as pharmaceutical agents
    Patent number: 7598260
    Abstract: This invention relates to pyrimidine derivatives of general formula I in which R1, R2, X, A and B have the meanings that are contained in the description, as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.
    Type: Grant
    Filed: June 26, 2007
    Date of Patent: October 6, 2009
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Thomas Brumby, Rolf Jautelat, Olaf Prien, Martina Schäfer, Gerhard Siemeister, Ulrich Lücking, Christoph Huwe
  • SULPHOXIMINE-SUBSTITUTED QUINAZOLINE DERIVATIVES AS IMMUNO-MODULATORS, THEIR PREPARATION AND USE AS MEDICAMENTS
    Publication number: 20090186911
    Abstract: The present invention relates to sulphoximine-substituted quinazoline derivatives of the formula (I), processes for their preparation and their use as a medicament for the treatment of various diseases.
    Type: Application
    Filed: June 13, 2008
    Publication date: July 23, 2009
    Inventors: Duy NGUYEN, Arne von Bonin, Michael Haerter, Hartmut Schirok, Anne Mengel, Martina Schaefer, Oliver von Ahsen
  • SULFONAMIDO-MACROCYCLES AS TIE2 INHIBITORS AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME
    Publication number: 20080039482
    Abstract: The invention relates to sulfonamido-macrocycles according to the general formula (I): in which R1, R2, R4, R5, R6, A, B, C, L, X, Y, Z, n, and m are as defined in the claims, and salts, N-oxides, or solvates thereof, to pharmaceutical compositions comprising said sulfonamido-macrocycles, to methods of preparing said sulfonamido-macrocycles as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 signalling.
    Type: Application
    Filed: June 20, 2007
    Publication date: February 14, 2008
    Inventors: Ingo Hartung, Hans Briem, Georg Kettschau, Karl-Heinz Thierauch, Ulrich Luecking, Ulf Boemer, Martina Schaefer, Philip Lienau
  • Macrocyclic pyrimidines, their production and use as pharmaceutical agents
    Patent number: 7312225
    Abstract: Macrocyclic pyrimidine derivatives of general formula I in which R1 to R5, X, Y, A, B, m and n have the meanings that are contained in the description, as inhibitors of the cyclin-dependent kinase, their processes for production as well as their use as medications for treating various diseases are described.
    Type: Grant
    Filed: August 20, 2003
    Date of Patent: December 25, 2007
    Assignee: Bayer Schering Pharma AG
    Inventors: Ulrich Luecking, Gerhard Siemeister, Martina Schaefer, Hans Briem
  • CDK-inhibitory pyrimidines, their production and use as pharmaceutical agents
    Patent number: 7291624
    Abstract: This invention relates to pyrimidine derivatives of general formula I in which R1, R2, X, A and B have the meanings that are contained in the description, as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.
    Type: Grant
    Filed: May 11, 2004
    Date of Patent: November 6, 2007
    Assignee: Bayer Schering Pharma AG
    Inventors: Thomas Brumby, Rolf Jautelat, Olaf Prien, Martina Schäfer, Gerhard Siemeister, Ulrich Lücking, Christoph Huwe
  • Compound and a composition including such a compound
    Patent number: 7235561
    Abstract: This invention relates to pyrimidine derivatives of general formula I in which R1, R2, X, A and B have the meanings that are contained in the description, as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.
    Type: Grant
    Filed: May 29, 2002
    Date of Patent: June 26, 2007
    Assignee: Schering AG
    Inventors: Thomas Brumby, Rolf Jautelat, Olaf Prien, Martina Schäfer, Gerhard Siemeister, Ulrich Lücking, Christoph Huwe
  • Sulfoximine-macrocycle compounds and salts thereof, pharmaceutical compositions comprising said compounds, methods of preparing same and uses of same
    Publication number: 20060252782
    Abstract: The invention relates to macrocyctic sulfoximines of the general Formula I: wherein A, X, Y, R1, R2 and R3 have the meaning as given in the specification and the claims, and to salts thereof; to pharmaceutical compositions comprising the macrocyclic sulfoximines, and to a method of preparing the macrocyclic sulfoximines, as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with angiopoietin and therefore influence Tie2 signalling.
    Type: Application
    Filed: April 7, 2006
    Publication date: November 9, 2006
    Inventors: Ulrich Luecking, Georg Kettschau, Hans Briem, Wolfgang Schwede, Martina Schaefer, Karl-Heinz Thierauch, Manfred Husemann
  • Pyrazolopyridines and salts thereof, a pharmaceutical composition comprising said compounds, a method of preparing same and use of same
    Publication number: 20060252754
    Abstract: The invention relates to pyrazolopyridines according to the general formula (I): and salts thereof, to pharmaceutical compositions comprising said pyrazolopyridines and to a method of preparing said pyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with angiopoietin and therefore influence Tie2 signalling.
    Type: Application
    Filed: January 23, 2006
    Publication date: November 9, 2006
    Inventors: Wolfgang Schwede, Hans Briem, Hermann Kuenzer, Manfred Husemann, Georg Kettschau, Martina Schaefer, Antonius Ter Laak, Karl-Heinz Thierauch, Stuart Ince
  • Sulfonamido-macrocycles as Tie2 inhibitors and the salts thereof, a pharmaceutical composition comprising these compounds, the method of preparing and the use thereof
    Publication number: 20060194823
    Abstract: The invention relates to sulfonamido-macrocycles according to the general Formula I and the salts thereof, to pharmaceutical compositions comprising the sulfonamido-macrocycles and to a method of preparing the sulfonamido-macrocycles as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with angiopoietin and therefore influence Tie2 signalling. wherein R1, R2, R4, A, X, Y, Z and m have the meaning as given in the specification and the claims.
    Type: Application
    Filed: December 21, 2005
    Publication date: August 31, 2006
    Inventors: Georg Kettschau, Hans Briem, Ingo Hartung, Ulrich Luecking, Martina Schaefer, Karl-Heinz Thierauch, Wolfgang Schwede, Manfred Husemann
  • Sulfonamido-macrocycles and the salts thereof, a pharmaceutical composition comprising these compounds, the method of preparing and the use thereof
    Publication number: 20060167030
    Abstract: The invention relates to sulfonamido-macrocycles according to the general Formula I and the salts thereof, to pharmaceutical compositions comprising the sulfonamido-macrocycles and to a method of preparing the sulfonamido-macrocycles as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with angiopoietin and therefore influence Tie2 signalling. wherein R1, R2 and R3 have the meaning as given in the specification and the claims.
    Type: Application
    Filed: December 21, 2005
    Publication date: July 27, 2006
    Inventors: Georg Kettschau, Hans Briem, Andreas Huth, Ulrich Luecking, Martina Schaefer, Karl-Heinz Thierauch, Wolfgang Schwede, Manfred Husemann
  • Macrocyclic pyrimidines, their production and use as pharmaceutical agents
    Publication number: 20040209895
    Abstract: Macrocyclic pyrimidine derivatives of general formula I 1
    Type: Application
    Filed: August 20, 2003
    Publication date: October 21, 2004
    Applicant: Schering AG
    Inventors: Ulrich Luecking, Gerhard Siemeister, Martina Schaefer, Hans Briem