Abstract: In some implementations, the system may include a plurality of wheel speed sensors, each of the plurality of wheel speed sensors being configured to monitor the speed of a respective wheel of a vehicle. In addition, the system may include a central electronic control unit. The system may include a plurality of controlling devices, each of the plurality of controlling devices being communicatively coupled to at least one wheel speed sensor of the plurality of wheel speed sensors. Moreover, the system may include a central electronic control unit communicatively coupled to each of the plurality of controlling devices via a network connection and configured to process data received from each of the controlling devices.

Abstract: The present invention relates to bispecific anti-CCL2 antibodies binding to two different epitopes on human CCL2, pharmaceutical compositions thereof, their manufacture, and use as medicaments for the treatment of cancers, inflammatory, autoimmune and ophthalmologic diseases.

Abstract: The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of prostate cancer. Thus, the present invention concerns compounds that are represented by the general Formulae (Ia) or (Ib).

Abstract: The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of prostate cancer. Thus, the present invention concerns compounds that are represented by the general Formulae (Ia) or (Ib).

Abstract: The present invention relates to bispecific anti-CCL2 antibodies binding to two different epitopes on human CCL2, pharmaceutical compositions thereof, their manufacture, and use as medicaments for the treatment of cancers, inflammatory, autoimmune and ophthalmologic diseases.

Abstract: An electrical connector includes: at least a first housing part and a second housing part, one of the first housing part and the second housing part engaging, at least partially and concentrically, in an other of the first housing part and the second housing part in an engagement region, the first housing part and the second housing part being rotatable relative to one another in the engagement region about an axis of rotation. The first housing part and the second housing part each have a magnetic structure extending, at least in part, circumferentially on an inside or an outside in the engagement region, the respective magnetic structures interacting.

Abstract: A vehicle steering wheel system is provided. The system includes a steering wheel body with a hub region for attachment to a steering shaft of a vehicle steering system, a steering wheel rim and at least one spoke for attaching the steering wheel rim to the hub region; an electromechanical triggering device for triggering an acoustic output by means of an acoustic warning device of the vehicle, wherein the triggering device has an impact absorber cover and at least one force transducer wherein a force value threshold is predefined for each force transducer, and a wake-up signal is transmitted via the data connection to the evaluation unit if the force value threshold is exceeded by at least one force value, so that the latter changes from the energy-saving mode into the operating mode in which an actuating force value is determined by force value measured by the at least one force transducer.

Abstract: Herein is reported a method for determining the concentration of a therapeutic antibody in a tissue of an experimental animal to whom the therapeutic antibody had been administered, wherein the interference from residual blood in a tissue sample of the experimental animal, which is used for determining the concentration of the therapeutic antibody in said tissue, is reduced by applying an inert reference antibody that does not penetrate into said tissue, whereby the inert reference antibody is administered 2 to 10 minutes prior to obtaining the tissue and blood sample.

Abstract: A computer-implemented method provides a time-dependent simulation model of a drive device. The drive device comprises an electric machine and a supply unit associated with the electric machine. A functional scope of the time-dependent simulation model is defined. A virtual image of the drive device is provided. The virtual image is modularly constructed, each module of the virtual image being configurable. In order to establish the time-dependent simulation model of the drive device with the defined functional scope, in accordance with the functional scope at least one module of the virtual image is selected and the at least one module is configured with respect to its level of detail.

Abstract: A production method for a component having integrated channels for internal fluid guidance, having a first region, which is connected to a second region, and wherein the channels extend both through the first region and through the second region. The geometry of the component is modified to the technological characteristics of both production methods. The first region is produced by a method for casting using lost models without undercuts, and proceeding from the first region, the second region is built up using an additive manufacturing method.

Abstract: Herein is reported a method for determining free antigen of an antibody in an undiluted serum sample comprising the steps of a) applying the undiluted sample to a solid phase on which a capture antibody has been immobilized to form a capture antibody-antigen complex, wherein the capture antibody competes with the antibody for binding to a first epitope on the antigen, b) applying to the solid phase a tracer antibody to form a capture antibody-antigen-tracer antibody complex, wherein the tracer antibody specifically binds to a second epitope on the antigen, wherein the epitope of the tracer antibody is not overlapping with the epitope of the capture antibody on the antigen, and c) determining the free antigen of the antibody by determining the tracer antibody in the capture antibody-antigen-tracer antibody complex.

Abstract: A power tool for processing a substrate, the power tool being designed for analyzing a composition of the substrate and including at least one recorder for recording an operating parameter of the power tool. A method for analyzing a composition of a substrate that is being processed by a proposed power tool is also provided. The analysis of the composition of the substrate takes place on the basis of the at least one recorded operating parameter which is recorded with the recording means, the analysis being performed in the power tool itself and during its operation.

Abstract: A method for releasing a screw connection between a core drilling device and a drill bit, wherein the screw connection is released by application of torque spikes to the drive shaft of the core drilling device, these torque spikes coming into effect when the drive shaft is driven counter to the actual drilling direction of the core drilling device. A core drilling device with which the proposed method can be carried out is also provided. To this end, the core drilling device includes a drive shaft to which torque spikes can be applied, wherein the drive shaft can be driven in a drilling direction and a second direction of rotation which is opposite to the drilling direction.

Abstract: The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers and imaging agents for various disease states of prostate cancer.

Abstract: The present invention relates to bispecific anti-CCL2 antibodies binding to two different epitopes on human CCL2, pharmaceutical compositions thereof, their manufacture, and use as medicaments for the treatment of cancers, inflammatory, autoimmune and ophthalmologic diseases.

Abstract: The present invention relates to a compound or a pharmaceutically acceptable salt thereof having a chemical structure comprising: A compound or a pharmaceutically acceptable salt thereof of formula (I): (A)-x1-(B)-x2-(C), wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; x1 is a spacer covalently connecting (A) and (B); x2 is a spacer or a chemical single bond connecting (B) and (C); wherein (C) has the formula wherein R1 to R4, R9, a, b, Y and X1 to X4 have the meaning as indicated in the claims and description. The invention further relates to compositions comprising said compounds as well as a method for detecting neoplastic cells in a sample in vitro with the aid of the compounds or composition.

Abstract: A plug-in contact device for preventing or extinguishing an arc when separating or closing a direct current connection includes: at least one plug-in connector each having a main contact, HA, and an auxiliary contact, HI, the HA including a first contact half, HA1, and a second contact half, HA2, which are releasably plugged together. The HA: electrically conductively connects the HA1 and the HA2 in a plugged-together state of the respective plug-in connector, galvanically separates the HA1 and the HA2 in a released state of the respective plug-in connector, electrically conductively connects the HA1 and the HA2 in a first intermediate state of the respective plug-in connector between the plugged-together state and the released state, and galvanically separates the HA1 and the HA2 in a second intermediate state of the respective plug-in connector between the first intermediate state and the released state.

Abstract: The present invention relates to a compound of a pharmaceutically acceptable salt thereof of formula (I) wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; x1 is a spacer or a chemical single bond covalently connecting (A) to the rest of the molecule; x2 is a spacer or a chemical single bond covalently connecting (C) to the rest of the molecule. The invention further relates to compositions comprising said compounds as well as a method for detecting neoplastic cells in a sample in vitro with the aid of the compounds or composition.

Abstract: An electric/electronic architecture for a motor vehicle includes an electronic computing device for communicating with at least one actuator of the motor vehicle. The electric/electronic architecture has an interface controller which is contacted by at least one sensor device of the motor vehicle and the electronic computing device, wherein the at least one actuator directly communicates with the electronic computing device, and the at least one sensor device directly communicates with the interface controller.

Abstract: A method for operating an internal combustion engine. The method includes: operating the internal combustion engine including a lambda regulation, which sets a fuel quantity to be supplied in accordance with a predefined setpoint lambda value, at preset times, carrying out a filter cleaning operation for a fuel tank ventilation, as a function of the presence of a release condition of the internal combustion engine, carrying out an adaptation of the lambda regulation by adapting at least one adaptation parameter as a function of operating variables of the internal combustion engine, at active filter cleaning operation and upon the presence of the release condition, operating variables which are required to carry out the adaptation of the lambda regulation being recorded, at deactivated filter cleaning operation and presence of the release condition, the adaptation of the lambda regulation being carried out as a function of the recorded operating variables.