Patents by Inventor Martina Tepla

Martina Tepla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antitumor composition based on hyaluronic acid and inorganic nanoparticles, method of preparation thereof and use thereof
    Patent number: 10617711
    Abstract: The invention relates to an antitumor composition based on hydrophobized hyaluronan and inorganic nanoparticles stabilized by oleic acid. The hydrophobized hyaluronan in the form of an acylated hyaluronan serves in the composition as a carrier of inorganic nanoparticles. Out of the group of inorganic nanoparticles, the composition may comprise superparamagnetic nanoparticles, nanoparticles of ZnO and moreover, upconversion nanoparticles. Said composition is selectively cytotoxic with respect to both suspension and adherent tumor cell lines, especially with respect to tumor cell lines of colorectum carcinoma and adenocarcinoma, lung carcinoma, hepatocellular carcinoma and breast adenocarcinoma. The highest cytotoxic effects were observed in case of the composition based on an oleyl derivative of hyaluronan with SPIONs. The composition of acylated hyaluronan with SPIONs may also be advantageously used for an in vivo detection of accumulation of the composition in the body, preferably in a tumor or in liver.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: April 14, 2020
    Assignee: Contipro a.s.
    Inventors: Daniela Smejkalova, Kristina Nesporova, Martina Tepla, Jakub Syrovatka, Gloria Huerta-Angeles, Martina Pospisilova, Vit Matuska, Jiri Mrazek, Andrea Galisova, Daniel Jirak, Vladimir Velebny
  • Antitumor Composition Based on Hyaluronic Acid and Inorganic Nanoparticles, Method of Preparation Thereof and Use Thereof
    Publication number: 20170143756
    Abstract: The invention relates to an antitumor composition based on hydrophobized hyaluronan and inorganic nanoparticles stabilized by oleic acid. The hydrophobized hyaluronan in the form of an acylated hyaluronan serves in the composition as a carrier of inorganic nanoparticles. Out of the group of inorganic nanoparticles, the composition may comprise superparamagnetic nanoparticles, nanoparticles of ZnO and moreover, upconversion nanoparticles. Said composition is selectively cytotoxic with respect to both suspension and adherent tumor cell lines, especially with respect to tumor cell lines of colorectum carcinoma and adenocarcinoma, lung carcinoma, hepatocellular carcinoma and breast adenocarcinoma. The highest cytotoxic effects were observed in case of the composition based on an oleyl derivative of hyaluronan with SPIONs. The composition of acylated hyaluronan with SPIONs may also be advantageously used for an in vivo detection of accumulation of the composition in the body, preferably in a tumor or in liver.
    Type: Application
    Filed: June 30, 2015
    Publication date: May 25, 2017
    Inventors: Daniela Smejkalova, Kristina Nesporova, Martina Tepla, Jakub Syrovatka, Gloria Huerta-Angeles, Martina Pospisilova, Vit Matuska, Jiri Mrazek, Andrea Galisova, Daniel Jirak, Vladimir Velebny