Patents by Inventor Martine Aiach

Martine Aiach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thrombin cleavable factor X analogues
    Patent number: 8168753
    Abstract: The invention relates to factor X analogues containing the thrombin-cleavable sequence Pro-Arg-Ala in place of the-sequence Thr-Arg-Ile of the activation site of native factor X. These factor X analogues can be used to obtain procoagulant medicinal products.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: May 1, 2012
    Assignee: Institut National de la Sante et de la Recherche Medicale
    Inventors: Virginie Louvain, Elsa Bianchini, Pierre-Emmanuel Marque, Claire Calmel-Tareau, Martine Aiach, Bernard Le Bonniec
  • Thrombin-cleavable chimeric proteins
    Patent number: 7589178
    Abstract: The invention relates to chimeric proteins comprising an artificial sequence for cleavage by thrombin, in which the activation peptide is fibrinopeptide A. Preferably, said chimeric proteins are derived from the zymogen of a serine protease such as PC or FX, by replacing the activation peptide of said zymogen with fibrinopeptide A, or a portion thereof, comprising at least amino acids P10 to P1 of said fibrinopeptide.
    Type: Grant
    Filed: October 18, 2002
    Date of Patent: September 15, 2009
    Assignee: Institut National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: Bernard Le Bonniec, Pierre-Emmanuel Marque, Virginie Louvain, Claire Calmel, Elsa Bianchini, Martine Aiach
  • Identification of polymorphisms in the epcr gene associated with thrombotic risk
    Publication number: 20090053693
    Abstract: The invention relates to an in vitro method for determining the risk of developing thrombosis in a subject, which method involves identifying a particular haplotype EPCR gene.
    Type: Application
    Filed: September 28, 2004
    Publication date: February 26, 2009
    Inventors: Martine Aiach, Sophie Gandrille, Beatrice Saposnik, Pascale Gaussem, Joseph Emmerich
  • Association of the h2 haplotype of the p2y12 receptor with an increased risk for thrombosis and peripheral arterial disease
    Publication number: 20060177821
    Abstract: The invention relates to an in vitro method for determining the risk of developing thrombosis in a subject, and to an in vitro method for determining sensitivity of a subject toward a thienopyridine therapy. Both methods involve identifying a particular haplotype of the P2Y12 receptor gene.
    Type: Application
    Filed: October 14, 2003
    Publication date: August 10, 2006
    Inventors: Martine Aiach, Pascale Gaussem, Pierre Fontana, Sophie Gandrille, Annabelle Dupont, Jean-Luc Reny
  • Thrombin cleavable factor x analogues
    Publication number: 20060148038
    Abstract: The invention relates to factor X analogues containing the thrombin-cleavable sequence Pro-Arg-Ala in place of the-sequence Thr-Arg-Ile of the activation site of native factor X. These factor X analogues can be used to obtain procoagulant medicinal products.
    Type: Application
    Filed: June 30, 2003
    Publication date: July 6, 2006
    Applicant: INST. NAT'L DE LA SANTE ET DE LA RECH. MEDICALE
    Inventors: Virginie Louvain, Elsa Bianchini, Pierre-Emmanuel Marque, Claire Calmel-Tareau, Martine Aiach, Bernard Le Bonniec
  • Thrombin-cleavable chimeric proteins
    Publication number: 20050202527
    Abstract: The invention relates to chimeric proteins comprising an artificial sequence for cleavage by thrombin, in which the activation peptide is fibrinopeptide A. Preferably, said chimeric proteins are derived from the zymogen of a serine protease such as PC or FX, by replacing the activation peptide of said zymogen with fibrinopeptide A, or a portion thereof, comprising at least amino acids P10 to P1 of said fibrinopeptide.
    Type: Application
    Filed: October 18, 2002
    Publication date: September 15, 2005
    Inventors: Bernard Le Bonniec, Pierre-Emmanuel Marque, Virginie Louvain, Claire Calmei, Elsa Bianchini, Martine Aiach
  • Method for determining predisposition to a venous thromboembolic disease
    Publication number: 20040254127
    Abstract: The invention concerns a method for detecting in vitro predisposition to a venous thromboembolic disease in a subject, which consists in determining whether the subject has been infected by a genus Chlamydia bacterium, in particular Chlamydia pneumoniae. The invention also concerns the use of active agents on genus Chlamydia bacteria for preventing and/or treating a venous thromboembolic disease.
    Type: Application
    Filed: April 23, 2004
    Publication date: December 16, 2004
    Inventors: Joseph Emmerich, Jean Noel Fiessinger, Martine Aiach