Patents by Inventor Martine Bos

Martine Bos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR REFOLDING NEISSERIAL NSPA PROTEIN
    Publication number: 20100291137
    Abstract: The present invention provides an isolated refolded NspA protein, and a method of preparing it.
    Type: Application
    Filed: January 25, 2010
    Publication date: November 18, 2010
    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Ralph Biemans, Martine Bos, Philippe Denoel, Christiane Feron, Carine Goraj, Jan Poolman, Vincent Weynants, Johannes Petrus Maria Tommassen
  • Vaccine
    Publication number: 20070031449
    Abstract: The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.
    Type: Application
    Filed: December 21, 2004
    Publication date: February 8, 2007
    Inventors: Martine Bos, Jan Poolman, Boris Tefsen, Johannes Tommassen