Patents by Inventor Martine Cerutti

Martine Cerutti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multispecific antigens binding fragments and multispecific antibodies
    Patent number: 11945879
    Abstract: The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CH1 and CL domains, said mutations preventing heavy chain/light chain mispairing.
    Type: Grant
    Filed: August 18, 2020
    Date of Patent: April 2, 2024
    Assignees: Jean Kadouche, Centre National de la Recherche Scientifique, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, University of Lausanne
    Inventors: Jean Kadouche, Jean-Pierre Mach, Olivier Michielin, Vincent Zoete, Justyna Iwaszkiewicz, Martine Cerutti, Sylvie Choblet, Josee Golay
  • BACULOVIRUS EXPRESSION SYSTEM
    Publication number: 20230063208
    Abstract: The invention relates to a method for producing a recombinant baculovirus comprising n exogenous genes in an insect cell, by means of homologous recombination of a replication-deficient baculovirus genome and n transfer vectors, each comprising one of the n exogenous genes, n being an integer at least equal to 2.
    Type: Application
    Filed: August 4, 2017
    Publication date: March 2, 2023
    Inventors: Martine CERUTTI, Sylvie JULIANT, Sylvie THERY
  • Specific binding molecule directed against galectin-3 protein
    Patent number: 11091552
    Abstract: A specific binding molecule is provided which binds to galectin-3 protein, methods of their production and methods of use.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: August 17, 2021
    Assignees: LABORATOIRE FRANAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE BORDEAUX
    Inventors: Alexandre Fontayne, Philippe Mondon, Jeanny Laroche-Traineau, Marie-Josée Jacobin-Valat, Martine Cérutti, Gisèle Clofent-Sanchez, Cyril Lorenzato, Audrey Hémadou
  • A SPECIFIC BINDING MOLECULE DIRECTED AGAINST GALECTIN-3 PROTEIN
    Publication number: 20210079101
    Abstract: A specific binding molecule is provided which binds to galectin-3 protein, methods of their production and methods of use.
    Type: Application
    Filed: October 5, 2018
    Publication date: March 18, 2021
    Inventors: Alexandre FONTAYNE, Philippe MONDON, Jeanny LAROCHE-TRAINEAU, Marie-Josée JACOBIN-VALAT, Martine CÉRUTTI, Gisèle CLOFENT-SANCHEZ, Cyril LORENZATO, Audrey HÉMADOU
  • Multispecific Antibodies
    Publication number: 20210040235
    Abstract: The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CHI and CL domains, said mutations preventing heavy chain/light chain mispairing.
    Type: Application
    Filed: August 18, 2020
    Publication date: February 11, 2021
    Inventors: Jean Kadouche, Jean-Pierre Mach, Olivier Michielin, Vincent Zoete, Justyna Iwaszkiewicz, Martine Cerutti, Sylvie Choblet, Josee Golay
  • Multispecific Antibodies
    Publication number: 20200385490
    Abstract: The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CHI and CL domains, said mutations preventing heavy chain/light chain mispairing.
    Type: Application
    Filed: August 18, 2020
    Publication date: December 10, 2020
    Inventors: Jean Kadouche, Jean-Pierre Mach, Olivier Michielin, Vincent Zoete, Justyna Iwaszkiewicz, Martine Cerutti, Sylvie Choblet, Josee Golay
  • Multispecific antigen binding fragments and multispecific antibodies derived therefrom comprising mutant CH1 and CL-kappa domains
    Patent number: 10815310
    Abstract: The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CH1 and CL domains, said mutations preventing heavy chain/light chain mispairing.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: October 27, 2020
    Assignees: Centre National de la Recherche Scientifique, Azienda socio sanitaria territoriale Papa Giovanni XXIII, Universite de Lausanne
    Inventors: Jean Kadouche, Jean-Pierre Mach, Olivier Michielin, Vincent Zoete, Justyna Iwaszkiewicz, Martine Cerutti, Sylvie Choblet, Josee Golay
  • BACULOVIRUS EXPRESSION SYSTEM
    Publication number: 20200263144
    Abstract: Method for preparing, in an insect cell, a recombinant baculovirus comprising one or more transgene(s) each encoding a protein maturation enzyme and n transgenes each encoding a polypeptide of interest, by homologous recombination between a replication deficient baculovirus genome which comprises one or more transgene(s) each encoding a protein maturation enzyme and n transfer vectors each comprising one of the n transgenes each encoding a polypeptide of interest, n being an integer at least equal to 2.
    Type: Application
    Filed: October 25, 2018
    Publication date: August 20, 2020
    Inventors: Martine CERUTTI, Sylvie JULIANT, Coralie BERNON
  • MULTISPECIFIC ANTIGENS BINDING FRAGMENTS AND MULTISPECIFIC ANTIBODIES DERIVED THEREFROM COMPRISING MUTANT CH1 AND CL-KAPPA DOMAINS
    Publication number: 20180022829
    Abstract: The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CH1 and CL domains, said mutations preventing heavy chain/light chain mispairing.
    Type: Application
    Filed: March 20, 2017
    Publication date: January 25, 2018
    Inventors: Jean Kadouche, Jean-Pierre Mach, Olivier Michielin, Vincent Zoete, Justyna Iwaszkiewicz, Martine Cerutti, Sylvie Choblet, Josee Golay
  • Multispecific antigens binding fragments and multispecific antibodies derived therefrom comprising mutant CH1 and CL-? domains
    Patent number: 9631031
    Abstract: The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CH1 and CL domains, said mutations preventing heavy/light chain mispairing.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: April 25, 2017
    Assignees: Centre National de la Recherche Scientifique, Azienda Ospedaliera Papa Giovanni XXIII, Universite de Lausanne
    Inventors: Jean Kadouche, Jean-Pierre Mach, Olivier Michielin, Vincent Zoete, Justyna Iwaszkiewicz, Martine Cerutti, Sylvie Choblet, Josee Golay
  • Compounds targeting the cation-independent mannose 6-phosphate receptor
    Patent number: 8962573
    Abstract: The invention relates to conjugates of products of interest including glycoproteins, nanoparticles, and imaging agents and of compounds of the general formula (1): that target the cation-independent mannose 6-phosphate receptor with a high affinity. The invention also relates to their applications, for instance in enzyme replacement therapies.
    Type: Grant
    Filed: July 2, 2010
    Date of Patent: February 24, 2015
    Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), Centre National de la Recherche Scientifique—CNRS, Universite de Montpellier 1, Universite de Montpellier 2 Sciences et Techniques
    Inventors: Marcel Garcia, Alain Morere, Magali Gary-Bobo, Martine Cerutti, Khaled El Cheikh, Ilaria Basile, Philippe Nirde
  • MULTISPECIFIC MUTATED ANTIBODY FAB FRAGMENTS
    Publication number: 20140242076
    Abstract: The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CH1 and CL domains, said mutations preventing heavy/light chain mispairing.
    Type: Application
    Filed: July 6, 2012
    Publication date: August 28, 2014
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE LAUSANNE, AZIENDA OSPEDALIERA PARA GIOVANNI XXIII
    Inventors: Jean Kadouche, Jean-Pierre Mach, Olivier Michielin, Vincent Zoete, Justyna Iwaszkiewicz, Martine Cerutti, Sylvie Choblet, Josee Golay
  • COMPOUNDS TARGETING THE CATION-INDEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR
    Publication number: 20120093795
    Abstract: The invention relates to conjugates of products of interest and of compounds targeting the cation-independent mannose 6-phosphate receptor with a high affinity. The invention also relates to their applications, for instance in enzyme replacement therapies.
    Type: Application
    Filed: July 2, 2010
    Publication date: April 19, 2012
    Applicants: INSERM (Institut National de la Sante et de la Recherche Medicale), UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES, UNIVERSITE DE MONTPELLIER 1, Centre National de la Recherche Scientifique-CNRS
    Inventors: Marcel Garcia, Alain Morere, Magali Gary-Bobo, Martine Cerutti, Khaled El Cheikh, Ilaria Basile, Philippe Nirde
  • Mutant Fab fragments of the chimeric 13B8.2 anti-CD4 antibody and their applications
    Patent number: 7482000
    Abstract: A mutant Fab fragment of the 13B8.2 anti-CD4 antibody that binds a CD4 molecule and includes a mutation of at least one residue in a position situated in the VH variable domain of the heavy chain and/or in a position situated in the V? variable domain of the light chain.
    Type: Grant
    Filed: January 5, 2005
    Date of Patent: January 27, 2009
    Assignee: Centre National de la Recherche Scientifique - CNRS
    Inventors: Christian Devaux, Cédric Bes, Laurence Briant-Longuet, Martine Cerutti, Gérard Devauchelle, Thierry Chardes, Claude Granier, Bernard Pau
  • Gp120 mutants and biological applications
    Patent number: 7078038
    Abstract: An isolated and purified human immunodeficiency virus type 1 (HIV-1) mutant gp120 envelope glycoprotein containing an amino acid mutation in position 112 which contains replacement of W with S, I, or F, wherein the numbering scheme is based upon the molecular clone HxBc2.
    Type: Grant
    Filed: November 29, 1999
    Date of Patent: July 18, 2006
    Assignee: Institut de Recherche pour le Developpement (I.R.D.)
    Inventors: Francisco Veas, Martine Cerutti
  • Expression receptors with 7 transmembrane domains in baculovirus-insect cell system
    Publication number: 20060009618
    Abstract: The invention concerns the expression in a baculovirus-insect cell system of receptors with seven transmembrane domains, in particular receptors coupled to proteins (;, in particular olfactory receptors, under the transcriptional control of a promoter derived from the polyhedrin promoter by deletion of all or part of the region of said promoter extending from ?1 to ?12 positions relative to the initiation site of the polyhedrin translation.
    Type: Application
    Filed: July 22, 2003
    Publication date: January 12, 2006
    Inventors: Gerard Devauchelle, Jacques Demaille, Conception Ferraz, Valery Matarazzo, Catherine Ronin, Martine Cerutti
  • Mutant fab fragments of the chimeric 13B8.2 anti-CD4 antibody and their applications
    Publication number: 20050226874
    Abstract: A mutant Fab fragment of the 13B8.2 anti-CD4 antibody that binds a CD4 molecule and includes a mutation of at least one residue in a position situated in the VH variable domain of the heavy chain and/or in a position situated in the V? variable domain of the light chain.
    Type: Application
    Filed: January 5, 2005
    Publication date: October 13, 2005
    Applicant: Centre National de la Recherche Scientifique - CNRS, a corporation of France
    Inventors: Christian Devaux, Cedric Bes, Laurence Briant-Longuet, Martine Cerutti, Gerard Devauchelle, Thierry Chardes, Claude Granier, Bernard Pau
  • Recombinant baculovirus and use thereof in the production of monoclonal antibodies
    Patent number: 6852507
    Abstract: Recombinant baculovirus used as an expression vector in the production of immunoglobulins with an insect cell. The invention is characterized by a first expression cassette comprising a first sequence coding for at least one portion of an immunoglobulin heavy chain, wherein the sequence is transcriptionally controlled by a first baculovirus promoter, and a second expression cassette comprising a second sequence coding for at least one portion of an immunoglobulin light chain, said second sequence being transcriptionally controlled by a second baculovirus promoter. The first and second promoters are two different promoters or derivatives of different promoters, the first and second promoters residing at different loci.
    Type: Grant
    Filed: November 21, 1997
    Date of Patent: February 8, 2005
    Assignees: Le Centre National de la Recherche Scientifique
    Inventors: Martine Cerutti, Hassan Chaabihi, Gerard Devauchelle, Laurent Gauthier, Michel Kaczorek, Marie-Paule LeFranc, Marie-Alix Poul
  • CDR-H1-derived peptide CB11, pharmaceutical compositions made therefrom and methods of treating disorders in mammals
    Publication number: 20030113322
    Abstract: An isolated CDR-derived polypeptide from monoclonal antibody 13B8.2, a pharmaceutical composition including a pharmaceutically acceptable carrier and at least a peptide, and a method for treating a subject suffering from an autoimmune disorder, including administering to the subject a therapeutically effective amount of a pharmaceutical composition, a method for treating a subject suffering from a transplant rejection including administering to the subject a therapeutically effective amount of a pharmaceutical composition, a method for treating a subject suffering from an HIV immunodeficiency disorder including administering to the subject a therapeutically effective amount of a pharmaceutical composition and a method for treating a subject suffering from a tumoral disorder including administering to the subject a therapeutically effective amount of a pharmaceutical composition.
    Type: Application
    Filed: December 18, 2002
    Publication date: June 19, 2003
    Inventors: Cedric Bes, Laurence Briant-Longuet, Martine Cerutti, Thierry Chardes, Gerard DeVauchelle, Christian DeVaux, Claude Granier, Claude Mawas, Daniel Olive, Bernard Pau
  • Use of a prolactin receptor or growth hormone receptor intracytoplasmic domain for achieving protein secretion
    Patent number: 6169172
    Abstract: The use of a prolactin receptor intracytoplasmic domain or a growth hormone receptor intracytoplasmic domain, or of a fragment of either one of said domains, for achieving the secretion of a protein of interest produced in a eukaryotic host cell, is disclosed.
    Type: Grant
    Filed: March 16, 1998
    Date of Patent: January 2, 2001
    Assignees: Institut National de la Recherche Agronomique (Inra), Centre National de la Recherche Scientifique (Cnrs)
    Inventors: G{acute over (e)}rard Devauchelle, Laurence Garnier, Claire Cahoreau, Martine Cerutti