Patents by Inventor Martine Moguilewsky

Martine Moguilewsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5276023
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 is an aliphatic hydrocarbon of 1 to 8 carbon atoms, R.sub.2 and R.sub.3 are individually hydrogen or alkyl of 1 to 4 carbon atoms, G is a hydrocarbon of 1 to 18 carbon atoms optionally containing at least one heteroatom and linked to the steroid nucleus by a carbon atom, X is X.sub.A or X.sub.B, X.sub.A is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, aralkyl of 7 to 15 carbon atoms, acyl of an organic carboxylic acid of 1 to 8 carbon atoms and Y is -B-O--CO--A-Z, B is a saturated or unsaturated, linear or branched alkylene of 1 to 8 carbon atoms, A is a saturated or unsaturated, linear or branched alkylene of 1 to 6 carbon atoms and optionally interrupted or ended by a bivalent aromatic or is a bivalent aromatic and Z is --COOH or --SO.sub.3 H which may be salified with an alkali metal, alkaline earth metal, an organic amine or --NH.sub.4 or X.sub.
    Type: Grant
    Filed: April 30, 1992
    Date of Patent: January 4, 1994
    Assignee: Roussel Uclaf
    Inventors: Martine Moguilewsky, Lucien Nedelec, Francois Nique, Daniel Philibert
  • Patent number: 5166146
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 is an aliphatic hydrocarbon of 1 to 8 carbon atoms, R.sub.a and R.sub.b are individually hydrogen or alkyl of 1 to 4 carbon atoms, R.sub.2 is hydrogen or optionally substituted alkyl of 1 to 12 carbon atoms, n is an integer from 1 to 6, Z is free carboxy or salified with an alkali metal, alkaline earth metal or NH.sub.4 and X is the remainder of an optionally substituted and optionally unsaturated 5 or 6-member ring and the wavy line indicates the .alpha.- or .beta.-position for R.sub.1 having anti-glucocorticoid activity.
    Type: Grant
    Filed: August 16, 1990
    Date of Patent: November 24, 1992
    Assignee: Roussel Uclaf
    Inventors: Martine Moguilewsky, Lucien Nedelec, Francois Nique, Daniel Philibert
  • Patent number: 5084472
    Abstract: A method of treating hormone-dependent cancer of an organ selected from the group consisting of bladder, brain, breast, lymphatic systems, kidney, liver, skin and ovaries in warm-blooded animals having such a cancer comprising administering to said warm-blooded animals an amount of 1-(3-'trifluoromethyl-4'-nitro-phenyl)-4,4-dimethyl-imidazoline-2,5-dione sufficient to combat said hormone-dependent cancer.
    Type: Grant
    Filed: May 29, 1990
    Date of Patent: January 28, 1992
    Assignee: Roussel
    Inventors: Martine Moguilewsky, Marie M. Bouton
  • Patent number: 5006518
    Abstract: Novel 19-nor steroids of the formula ##STR1## wherein R' is selected from the group consisting of propyl, propenyl, iodoethenyl, iodoethynyl or --C.tbd.C--CH.sub.2 --Hal.sub.1, Hal.sub.1 is selected from the group consisting of fluorine, chlorine and bromine and their non-toxic, pharmaceutically acceptable acid addition salts having a remarkable antiglucocorticoid and antiprogestomimetic activity.
    Type: Grant
    Filed: December 30, 1988
    Date of Patent: April 9, 1991
    Assignee: Roussel Uclaf
    Inventors: Martine Moguilewsky, Lucien Nedelec, Francois Nique, Daniel Philibert
  • Patent number: 4943566
    Abstract: A compound selected from the group consisting of compounds of the formula ##STR1## wherein R.sub.1 is an organo of 1 to 18 carbon atoms optionally containing at least one heteroatom connected to the C ring by a carbon atom, R.sub.2 is methyl or ethyl, the A and B rings being selected from the group consisting of ##STR2## Re is selected from the group consisting of hydrogen, optionally substituted alkyl of 1 to 6 carbon atoms and acyl and the D ring is selected from the group consisting of ##STR3## one of R.sub.3 and R.sub.4 is selected from the group consisting of hydroxy, protected hydroxy, acyl and alkoxy and the other is an optionally substituted aryl, R.sub.5 is an optionally substituted aryl and their non-toxic, pharmaceutically acceptable salts with acids and bases with the proviso that when the A and B rings are ##STR4## R.sub.1 is ##STR5## R.sub.2 is methyl, R.sub.3 is --OH, R.sub.4 is phenyl having anti proliferative properties.
    Type: Grant
    Filed: July 28, 1988
    Date of Patent: July 24, 1990
    Assignee: Roussel Uclafi
    Inventors: Lucien Nedelec, Francois Nique, Daniel Philibert, Martine Moguilewsky, Marie-Madeleine Bouton
  • Patent number: 4921846
    Abstract: Steroids with a 17-spiro substituent of 3,4 or 6 ring members of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of carbocyclic aryl, heterocyclic aryl and aralkyl, R.sub.2 is a hydrocarbon of 1 to 18 carbon atoms in the .alpha.-or .beta.-position, the wavy line of the spiro ether indicates the oxygen is .alpha.-or .beta.-, X is selected from the group consisting of --CH.dbd.CH--CH.sub.2 --CH.sub.2 -- and --(CH.sub.2).sub.n --, n is 1, 2 or 4, the A and B rings have a structure selected from the group consisting of ##STR2## R' and R" are individually hydrogen or alkyl of 1 to 4 carbon atoms, R.sub.e is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, substituted alkyl of 1 to 6 carbon atoms and acyl and their non-toxic, pharmaceutically acceptable acid addition salts having a remarkable antiprogestomimetic activity.
    Type: Grant
    Filed: September 16, 1988
    Date of Patent: May 1, 1990
    Assignee: Roussel Uclaf
    Inventors: Lucien Nedelec, Andre Claussner, Daniel Philibert, Martine Moguilewsky
  • Patent number: 4900725
    Type: Grant
    Filed: November 25, 1987
    Date of Patent: February 13, 1990
    Assignee: Roussel Uclaf
    Inventors: Francois Nioue, Lucien Nedelec, Daniel Philibert, Martine Moguilewsky
  • Patent number: 4873256
    Abstract: A compound in all possible racemic and optically active forms of the formula ##STR1## wherein .dbd.X is .dbd.O or imino having antiandrogenic activity and novel intermediates and processes for their preparations.
    Type: Grant
    Filed: August 10, 1988
    Date of Patent: October 10, 1989
    Assignee: Roussel Uclaf
    Inventors: Daniel Coussediere, Giuseppe Gigliotti, Martine Moguilewsky
  • Patent number: 4865767
    Abstract: Novel radioactive steroids labelled with tritium of the formula ##STR1## wherein .sup.3 H is tritium and R and R.sub.1 are individually selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 1 to 10 carbon atoms useful for revealing receptors of glucocorticoids and in determining the number of fixation sites of glucocorticoids and novel intermediates.
    Type: Grant
    Filed: December 19, 1985
    Date of Patent: September 12, 1989
    Assignee: Roussel Uclaf
    Inventors: Alain Jouquey, Daniel Philibert, Martine Moguilewsky, Jean-Noel Veltz
  • Patent number: 4664850
    Abstract: Novel radioactive steriods labelled with tritium of the formula ##STR1## wherein .sup.3 H is tritium and R and R.sub.1 are individually selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 1 to 10 carbon atoms useful for revealing receptors of glucocorticoids and in determining the number of fixation sites on glucocorticoids and novel intermediates.
    Type: Grant
    Filed: June 14, 1984
    Date of Patent: May 12, 1987
    Assignee: Roussel Uclaf
    Inventors: Alain Jouquey, Daniel Philibert, Martine Moguilewsky, Jean-Noel Veltz