Patents by Inventor Martyn Caplin

Martyn Caplin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination treatment of pancreatic cancer
    Patent number: 8388966
    Abstract: A combination for use in the treatment of pancreatic cancer comprising: (i) an anti-gastrin effective immunogenic composition; and, (ii) one or more chemotherapeutic agents suitable for inhibiting cancer growth.
    Type: Grant
    Filed: August 8, 2008
    Date of Patent: March 5, 2013
    Assignee: Cancer Advances, Inc.
    Inventors: Philip C. Gevas, Dov Michaeli, Stephen Grimes, Martyn Caplin
  • Combination treatment of pancreatic cancer
    Publication number: 20090004200
    Abstract: A combination for use in the treatment of pancreatic cancer comprising: (i) an anti-gastrin effective immunogenic composition; and, (ii) one or more chemotherapeutic agents suitable for inhibiting cancer growth.
    Type: Application
    Filed: August 8, 2008
    Publication date: January 1, 2009
    Inventors: Philip C. Gevas, Dov Michaeli, Stephen Grimes, Martyn Caplin
  • Combination treatment of pancreatic cancer
    Publication number: 20060140962
    Abstract: A combination for use in the treatment of pancreatic cancer comprising: (i) an anti-gastrin effective immunogenic composition; and, (ii) one or more chemotherapeutic agents suitable for inhibiting cancer growth.
    Type: Application
    Filed: February 22, 2006
    Publication date: June 29, 2006
    Inventors: Philip Gevas, Dov Michaeli, Stephen Grimes, Martyn Caplin
  • Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors
    Publication number: 20040001842
    Abstract: The invention concerns immunogens, immunogenic compositions and method for the treatment of gastrin-dependent tumors. The immunogens comprise a gastrin receptor immunomimic peptide conjugated to an immunogenic carrier. The immunogens are capable of inducing antibodies in vivo which bind to the gastrin-receptor (GR) in gastrin responsive malignant or premalignant tumor, thereby preventing growth stimulating peptide hormones from binding to the receptors, and inhibiting tumor cell growth. The invention also comprises specific antibodies against the gastrin-receptor for passive immunization. Furthermore, the invention comprises cytotoxic molecule derivatized anti-GR antibodies. The invention also concerns diagnostic methods for detecting gastrin-dependent tumors in vivo or from a tissue biopsy using the antibodies of the invention. Active and passive immunization can be combined providing an immune response against GR, G17 and/or G17-Gly.
    Type: Application
    Filed: December 19, 2002
    Publication date: January 1, 2004
    Inventors: Dov Michaeli, Martyn Caplin, Susan A. Watson, Stephen Grimes
  • Combination treatment of pancreatic cancer
    Publication number: 20030091574
    Abstract: A combination for use in the treatment of pancreatic cancer comprising:
    Type: Application
    Filed: March 22, 2002
    Publication date: May 15, 2003
    Inventors: Philip C. Gevas, Dov Michaeli, Stephen Grimes, Martyn Caplin
  • Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors
    Publication number: 20030086941
    Abstract: The invention concerns immunogens, immunogenic compositions and method for the treatment of gastrin-dependent tumors. The immunogens comprise a peptide from the CCK-B/gastrin-receptor conjugated to a spacer and to an immunogenic carrier. The immunogens are capable of inducing antibodies in vivo which bind to the CCK-B/gastrin-receptor in tumor cells, thereby preventing growth stimulating peptide hormones from binding to the receptors, and inhibiting tumor cell growth. The immunogens also comprise antibodies against the CCK-B/gastrin-receptor for passive immunization. The invention also concerns diagnostic methods for detecting gastrin-dependent tumors in vivo or from a tissue biopsy using the antibodies of the invention.
    Type: Application
    Filed: September 4, 2002
    Publication date: May 8, 2003
    Inventors: Dov Michaeli, Martyn Caplin, Susan A. Watson, Stephen Grimes
  • Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors
    Patent number: 6548066
    Abstract: The invention concerns immunogens, immunogenic compositions and method for the treatment of gastrin-dependent tumors. The immunogens comprise a peptide from the CCK-B/gastrin-receptor conjugated to a spacer and to an immunogenic carrier. The immunogens are capable of inducing antibodies in vivo which bind to the CCK-B/gastrin-receptor in tumor cells, thereby preventing growth stimulating peptide hormones from binding to the receptors, and inhibiting tumor cell growth. The immunogens also comprise antibodies against the CCK-B/gastrin-receptor for passive immunization. The invention also concerns diagnostic methods for detecting gastrin-dependent tumors in vivo or from a tissue biopsy using the antibodies of the invention.
    Type: Grant
    Filed: May 12, 1998
    Date of Patent: April 15, 2003
    Assignee: Aphton Corporation
    Inventors: Dov Michaeli, Martyn Caplin, Susan A. Watson, Stephen Grimes