Abstract: The invention relates to compounds of formula I wherein R1, R2 and - - - - - are as defined herein, pharmaceutical compositions comprising the compounds and methods of treating COVID-19 in a patient by administering therapeutically effective amounts of the compounds and methods of inhibiting or preventing replication of SARS-CoV-2 with the compounds.

Abstract: A gas turbine engine fan blade apparatus is disclosed comprising a reverse pitch rotatable mounting and an aerofoil part. The aerofoil part comprises radially inner and radially outer portions that are separated by an interface extending from a leading edge of the aerofoil part to a trailing edge of the aerofoil part. The reverse pitch rotatable mounting locates the radially inner and radially outer portions with respect to one another. The reverse pitch rotatable mounting and separation at the interface permit relative pitch change rotation between the radially inner and radially outer portions such that one of the radially inner and radially outer portions is rotatable to a reverse pitch configuration by comparison with the other portion.

Abstract: A centralized social network tool is configured to interface with and integrates into one or more videogames and/or videogame series. The social network tool may be integral to the theme of the games and be pervasive within game play. The social network may drive progression of the story and interaction between characters. According to another aspect of the invention, the members of the social network may include actual members (corresponding to real people) and virtual members (e.g., artificial intelligence controlled bot members). The virtual members may be part of the social network and may interact with real members within and outside of the game as part of the theme of the game.

Abstract: A gas turbine engine fan blade apparatus is disclosed comprising a reverse pitch rotatable mounting and an aerofoil part. The aerofoil part comprises radially inner and radially outer portions that are separated by an interface extending from a leading edge of the aerofoil part to a trailing edge of the aerofoil part. The reverse pitch rotatable mounting locates the radially inner and radially outer portions with respect to one another. The reverse pitch rotatable mounting and separation at the interface permit relative pitch change rotation between the radially inner and radially outer portions such that one of the radially inner and radially outer portions is rotatable to a reverse pitch configuration by comparison with the other portion.

Abstract: A thermal management system for a gas turbine engine comprises a plurality of first heat generating sub-systems arranged in operable communication with the engine, a fuel supply sub-system, a fuel circulation sub-system, and one or more combustors. The fuel supply sub-system is adapted to supply a de-oxygenated fuel to the fuel circulation sub-system, and the fuel circulation sub-system is adapted to circulate the de-oxygenated fuel to lubricate and cool each of the plurality of first heat generating sub-systems, and then to combust the de-oxygenated fuel in the or each combustor.

Abstract: A centralized social network tool is configured to interface with and integrates into one or more videogames and/or videogame series. The social network tool may be integral to the theme of the games and be pervasive within game play. The social network may drive progression of the story and interaction between characters. According to another aspect of the invention, the members of the social network may include actual members (corresponding to real people) and virtual members (e.g., artificial intelligence controlled bot members). The virtual members may be part of the social network and may interact with real members within and outside of the game as part of the theme of the game.

Abstract: A system and method are configured to provide a videogame to one or more players. The videogame may involve a series of different sets of content within which players perform activities. A group of players may be associated with the content sets. The players may include virtual players controlled by artificial intelligence and one or more real world players. Players may progress through the videogame by moving from content sets to content sets, performing objectives in the various content sets, and interacting with the players within those content sets.

Abstract: A centralized social network tool is configured to interface with and integrates into one or more videogames and/or videogame series. The social network tool may be integral to the theme of the games and be pervasive within game play. The social network may drive progression of the story and interaction between characters. According to another aspect of the invention, the members of the social network may include actual members (corresponding to real people) and virtual members (e.g., artificial intelligence controlled bot members). The virtual members may be part of the social network and may interact with real members within and outside of the game as part of the theme of the game.

Abstract: An epicyclic gearbox oil scavenge arrangement. The epicyclic gearbox is of the planetary or differential type and comprises an input sun gear (28); a plurality of planet gears (32) that mesh with the sun gear (28) and are driven therefrom; an annular planet carrier (34) that couples the planet gears (32) in known relative orientation and is configured to precess around the sun gear (28); and a ring gear (38) that meshes with each planet gear (32). The ring gear (38) comprises ejection apertures (44) that extend radially therethrough and the planet carrier (34) comprises at least one lobe (42) that extends radially from the periphery of the planet carrier.

Abstract: A centralized social network tool is configured to interface with and integrates into one or more videogames and/or videogame series. The social network tool may be integral to the theme of the games and be pervasive within game play. The social network may drive progression of the story and interaction between characters. According to another aspect of the invention, the members of the social network may include actual members (corresponding to real people) and virtual members (e.g., artificial intelligence controlled bot members). The virtual members may be part of the social network and may interact with real members within and outside of the game as part of the theme of the game.

Abstract: A system and method are configured to provide a videogame to one or more players. The videogame may involve a series of different sets of content within which players perform activities. A group of players may be associated with the content sets. The players may include virtual players controlled by artificial intelligence and one or more real world players. Players may progress through the videogame by moving from content sets to content sets, performing objectives in the various content sets, and interacting with the players within those content sets.

Abstract: A system and method are configured to provide a videogame to one or more players. The videogame may involve a series of different sets of content within which players perform activities. A group of players may be associated with the content sets. The players may include virtual players controlled by artificial intelligence and one or more real world players. Players may progress through the videogame by moving from content sets to content sets, performing objectives in the various content sets, and interacting with the players within those content sets.

Abstract: A system and method are configured to provide a videogame to one or more players. The videogame may involve a series of different sets of content within which players perform activities. A group of players may be associated with the content sets. The players may include virtual players controlled by artificial intelligence and one or more real world players. Players may progress through the videogame by moving from content sets to content sets, performing objectives in the various content sets, and interacting with the players within those content sets.

Abstract: An epicyclic gearbox oil scavenge arrangement. The epicyclic gearbox is of the planetary or differential type and comprises an input sun gear (28); a plurality of planet gears (32) that mesh with the sun gear (28) and are driven therefrom; an annular planet carrier (34) that couples the planet gears (32) in known relative orientation and is configured to precess around the sun gear (28); and a ring gear (38) that meshes with each planet gear (32). The ring gear (38) comprises ejection apertures (44) that extend radially therethrough and the planet carrier (34) comprises at least one lobe (42) that extends radially from the periphery of the planet carrier.

Abstract: A centralized social network tool is configured to interface with and integrates into one or more videogames and/or videogame series. The social network tool may be integral to the theme of the games and be pervasive within game play. The social network may drive progression of the story and interaction between characters. According to another aspect of the invention, the members of the social network may include actual members (corresponding to real people) and virtual members (e.g., artificial intelligence controlled bot members). The virtual members may be part of the social network and may interact with real members within and outside of the game as part of the theme of the game.

Abstract: A system and method are configured to provide a videogame to one or more players. The videogame may involve a series of different virtual geographic locations at which players perform activities. A group of players may be associated with each location. The players may include virtual players controlled by artificial intelligence and one or more real world players. Players may progress through the videogame by moving from location to location, performing objectives at the various locations, and interacting with the players at the locations.

Abstract: A centralized social network tool is configured to interface with and integrates into one or more videogames and/or videogame series. The social network tool may be integral to the theme of the games and be pervasive within game play. The social network may drive progression of the story and interaction between characters. According to another aspect of the invention, the members of the social network may include actual members (corresponding to real people) and virtual members (e.g., artificial intelligence controlled bot members). The virtual members may be part of the social network and may interact with real members within and outside of the game as part of the theme of the game.

Abstract: A selective rotation arrangement for a shaft, the arrangement including a housing mountable spaced from the shaft and an engagement member with distal and proximal ends which is selectively movable relative to the housing towards or away from the shaft between an operating position towards the shaft and a rest position clear of the shaft, the engagement member having a gear member at the distal end thereof which is engageable with the shaft in the operating position to permit turning of the shaft by the engagement member, but is disengaged from the shaft in the rest position.

Abstract: In prop fan and contra fan gas turbine engines particularly utilized with regard to pusher configurations towards the aft of an aircraft, there is a significant problem with regard to debris and bird strikes resulting in particulate matter which may damage the engine thrust core. By providing an inlet rotor which fragments and creates a centrifugal aspect to the inlet flow, particulate matter can be directed to a bypass chute normally in the form of an annular section extending into a number of chute exits. In such circumstances, the particulate matter is removed continuously from the inlet flow and the chutes are normally angled to project any particulate matter towards propellers of the engine at robust positions.

Abstract: Disparities between optimum engine thrust for aircraft operation and power necessary to drive an ancillary machine such an electrical power generator can cause problems within a turbine engine. Clearly, it is necessary to continue developing sufficient electrical power for control and other systems within an aircraft despite aircraft thrust requirements. Previously, some compressed air flow has been bypassed in order to maintain compressor stability, but unfortunately such bypass systems within turbine engines can have a thrust recovery regime such that there is excess thrust in comparison with that actually necessary.