Abstract: The invention relates generally to conjugated activatable antibodies that bind CD71 in their active form and methods of making and using these anti-CD71 conjugated activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: At a managed control plane service, end-user application programming interfaces (APIs) of an application to be implemented at a provider network are determined. A set of common operational requirements of the application, to be fulfilled without obtaining program code for the requirements, are identified. In response to an invocation of an end-user API of the application, computations are performed at a resource selected by the managed control plane service, and one or more tasks to satisfy a common operational requirement are initiated by the managed control plane service.

Abstract: The invention relates generally to conjugated activatable antibodies that bind CD71 in their active form and methods of making and using these anti-CD71 conjugated activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: The invention provides methods for obtaining compositions having antibody drug conjugates (ADCs) with specified drug to antibody ratios (DARs). Included in the invention is a method for purifying an ADC mixture having ADCs with a drug loaded species of 6 or more by contacting the mixture with a hydrophobic resin such that a composition comprising less than 15% of the 6 or more drug loaded species is obtained. The invention also provides a composition wherein 70% or more of the ADCs present have a drug loaded species of 4 or less, wherein the ADC comprises an anti-EGFR antibody and an auristatin.

Abstract: The invention relates generally to conjugated activatable antibodies that bind CD71 in their active form and methods of making and using these anti-CD71 conjugated activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: An apparatus having a radiant heater, an upwardly convex reflector, a vertically-oriented cylindrical ring shield joined to the reflector at the outside reflector diameter, an upwardly convex metal hood, and an upwardly convex cap having a cap diameter greater than the diameter of a hood opening, wherein exhaust gases emitted upwardly from the exhaust port draw cooler air through the cylindrical opening, the exhaust gases and cooler air pass upward through the hood, drawing additional cooler air through the annular space between the reflector and the hood, into a mixing chamber formed by the cap and the hood, where the cooler air and the exhaust gases mix and the mixed air and exhaust gases then pass outward through the annular space between the cap and the hood, exiting the apparatus at the outer diameter of the cap.

Abstract: An apparatus has a housing having a top and bottom and a sidewall, with one or more horizontally-directed outlet openings through the sidewall and one or more inlet openings through the top, bottom or sidewall, one or more fans positioned to draw air through the one or more inlet openings, and to the air outward through the one or more horizontally-directed outlet openings, and a power source for the one or more fans, suitably connected through an on-off switch to turn the one or more fans on and off.

Abstract: The invention provides methods for obtaining compositions having antibody drug conjugates (ADCs) with specified drug to antibody ratios (DARs). Included in the invention is a method for purifying an ADC mixture having ADCs with a drug loaded species of 6 or more by contacting the mixture with a hydrophobic resin such that a composition comprising less than 15% of the 6 or more drug loaded species is obtained. The invention also provides a composition wherein 70% or more of the ADCs present have a drug loaded species of 4 or less, wherein the ADC comprises an anti-EGFR antibody and an auristatin.

Abstract: There is provided a hemihydrate of (3?,5?,7?,12?)-7,12-dihydroxy-3-{2-[{4-[17?-hydroxy-3-oxo-17?-prop-1-ynylestra-4,9-dien-11?-yl]phenyl}(methyl)amino]ethoxy}cholan-24-oic acid in a crystalline form which is characterised by an X-ray diffraction pattern having major peaks at 2?=6.58±0.2, 8.54+0.2, 12.28±0.2, and 19.68±0.2. This crystalline material is useful in the treatment of conditions associated with an excess of hepatic glucocorticoid response.

Abstract: There is provided a hemihydrate of (3?, 5?, 7?, 12?)-7,12-dihydroxy-3-{2-[{4-[17?-hydroxy-3-oxo-17?-prop-1-ynylestra-4,9-dien-11?-yl]phenyl}(methyl)amino]ethoxy}cholan-24-oic acid in a crystalline form which is characterised by an X-ray diffraction pattern having major peaks at 2?=6.58±0.2, 8.54+0.2, 12.28±0.2, and 19.68±0.2. This crystalline material is useful in the treatment of conditions associated with an excess of hepatic glucocorticoid response.

Abstract: This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in the regulation of metabolism, especially lowering serum glucose levels, insulin levels, or lipid levels, and/or decreasing body weight.

Abstract: This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in the regulation of metabolism, especially lowering serum glucose levels, insulin levels, or lipid levels, and/or decreasing body weight.

Abstract: This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in the regulation of metabolism, especially lowering serum glucose levels, insulin levels, or lipid levels, and/or decreasing body weight.

Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2′-substituted and optionally 4″-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.

Abstract: A toy money box resembling a slot machine has one money slot where the money enters a store and is returned if the slot machine when operated gives a jackpot. The money box has a second slot where money passes to a store separate from the slot machine and acts as a conventional money box. A mechanism for controlling the slot machine is provided which is simpler than previous mechanisms. In one aspect, the chance wheels are rotated by a gear drive which rotates one chance wheel through a one-way clutch and similar one-way clutches between adjacent pairs of chance wheels impart the rotation sequentially to all of the wheels. A clutch mechanism between the operating handle and the gear drive can comprise a pawl rotatably engaged within a cylindrical sleeve, the end of the pawl engaging a opening in the sleeve for transmitting rotary motion from the pawl to the sleeve and a cam being provided to disengage the end of the pawl when a particular extent of rotation has been reached.

Abstract: A drive puck for use as a component in a demand drive system is disclosed herein in which a film roller is resiliently centered on a rotating drive shaft so that the tension of a film strip carried thereon selectively causes engagement of the film roller with the drive puck. The puck is secured to the drive shaft so as to rotate therewith and is provided with an external tread which projects into a lateral cavity of the film roller so as to engage with the underside of the film roller in response to the resilient centering movement of the film roller.

Abstract: A wheel for a skating apparatus is operably carried on a truck so as to selectively rotate in a given direction or in both directions. A bearing assembly rotatably mounts the wheel on one end of an axle outwardly projecting from a skate truck. The bearing assembly includes a pair of races between which bearings are rollably disposed. An adjustable bearing assembly is operably coupled between the opposing surfaces of the truck and the inside of the wheel. Bearings in this latter assembly are rollable in a circular cage having the bearing surfaces engagable with a flat raceway carried on the truck wherein the wheel rotates in a first direction when the bearing engages with a circular portion of an eccentric and ceases rotation when the bearing engages with a flattened ramp portion of the eccentric. In an alternate embodiment the first mentioned bearing assembly includes the eccentric raceway on one side of the cage holding the bearings and the flat surface race on the opposite side.

Abstract: An apparatus is described herein which when used in conjunction with a continuous film duplicator or printer, stores and transports micrographic, motion picture, and other masters during the printing cycle to eliminate rewinding when making multiple duplicate copies. The apparatus is modular utilizing a pair of carriages so that it may be expanded either horizontally or vertically to accommodate more footage. A single motor is employed to adjust the spacing between top and bottom roller sets disposed on the carriages for various lengths of film while a three-position sensor arm controls the motor. A slack sensor controls the speed of rollers mounted on shafts on the carriages and a motor drives each shaft controlled by the sensor. Low-mass plastic film rollers equipped with soft-touch rubber surfaces are employed for transporting the film and low inertia PM motors provide high acceleration and torque for driving the shafts.

Abstract: An unknown segment such as a spoken digit in a continuous speech signal is recognized as a previously identified speech segment by deriving a set of test linear prediction characteristic signals from the voiced interval of the unknown segment. The test signals are time aligned to the average voiced interval of repetitions of each of a plurality of identified speech segments for which average reference voiced interval linear prediction characteristic signals were previously generated. The correspondence between the aligned test signals and the reference signals is determined. The unknown speech segment is identified as the reference segment having the closest correspondence with the unknown segment. Features of the invention include: voiced-region parameter signals, and classification and consistency detection; and determining means and variances of voiced-region parameters from a plurality of speakers utilized for the correspondence arrangements.

Abstract: This speaker recognition system offers improved recognition by comparing the mean and variance of an unknown (test) speaker's Orthogonal Parameter signals versus those of previously-stored known (reference) speakers. The unknown speaker's Orthogonal Parameters represent his hypothesized identity because his original speech linear prediction coefficients are transformed into his set of Orthogonal Parameters using the stored (reference) transformation coefficients of each of the previously-recorded known speakers.