Abstract: A naturally occurring anorexic composition of matter that does not alter locomotor function comprising the water soluble constituents of the coca leaf (Erythroxylon coca). Anorexic compositions consisting of the foregoing described product prepared from coca leaves in admixture with a non-toxic, pharmaceutically acceptable carrier. A method of suppressing appetite levels in animals comprising administering a therapeutically effective concentration of the inventive product in a pharmaceutically suitable carrier intravenously, orally, intraperitioneally and intramuscularly. The method of preparing an anorexically active product from coca leaves.