Patents by Inventor Marvin D. Schulman

Marvin D. Schulman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bioconversion products of 27-hydroxy avermectin
    Patent number: 5478929
    Abstract: There are disclosed novel compounds which are derived from 22,23-dihydro avermectin B1 aglycone. The compounds are both isomers of the 27-hydroxy adduct of the substrate avermectin compound that have been glycosylated at the 4" position to yield 4"-O-glucosyl 27-OH avermectin compounds. The compounds and the intermediates used to make them are highly potent antiparasitic, insecticidal and anthelmintic avermectin agents.
    Type: Grant
    Filed: May 20, 1994
    Date of Patent: December 26, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Byron H. Arison, Patrick J. Doherty, Marvin D. Schulman
  • Process for the glycosylation of avermectin compounds
    Patent number: 5192671
    Abstract: Avermectin compounds are glycosylated the 4' and 4"-positions by adding the avermectin compounds to the fermentation medium of Saccharapolyspora erythrea. The outer oleandrose sugar group of the avermectin compound is glycosylated with a glycosyl moiety, specifically a glucose group. In addition, other changes are effected in the avermectin moiety such as selective hydroxylation, epimerization at the 2-carbon and migration of the .DELTA. 3-double bond to a .DELTA. 2-position.
    Type: Grant
    Filed: June 26, 1991
    Date of Patent: March 9, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Byron H. Arison, Marvin D. Schulman, Patrick J. Doherty
  • Process for the glycosylation of avermectin agylcones
    Patent number: 5188944
    Abstract: Avermectin aglycones are glycosylated by fermentation in a medium of a non-producing mutant of Streptomyces avermitilis MA-6078. The glycosylation produces the monosaccharide and disaccharide derivatives while leaving the remainder of the molecule intact. The microorganism glycosylates with the .alpha.-L-oleandrose moiety.
    Type: Grant
    Filed: September 19, 1991
    Date of Patent: February 23, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Mary N. Omstead, Marvin D. Schulman, Noel M. Young
  • 28-hydroxy ivermectin aglycone
    Patent number: 5140042
    Abstract: Fermentation of S. erythraea produces the novel avermectin, 28-hydroxy ivermectin aglycone.
    Type: Grant
    Filed: September 12, 1990
    Date of Patent: August 18, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Byron H. Arison, Marvin D. Schulman, Patrick J. Doherty
  • Fermentation process for the preparation of ivermectin aglycone
    Patent number: 5124258
    Abstract: Fermentation of S. erythraea produces the novel avermectin, 28-hydroxy ivermectin aglycone.
    Type: Grant
    Filed: September 12, 1990
    Date of Patent: June 23, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Byron H. Arison, Patrick J. Doherty, Marvin D. Schulman