Patents by Inventor Marvin I. Siegel

Marvin I. Siegel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TARGETED PROTEIN CAGES
    Publication number: 20090035389
    Abstract: The present invention provides targeted protein cages for the specific delivery of a variety of agents to cells and tissues and methods of use. The targeted protein cages have exterior targeting moieties and therapeutic or imaging agents which are encapsulated within the protein cages or are located on the exterior surfaces of the protein cages.
    Type: Application
    Filed: February 22, 2008
    Publication date: February 5, 2009
    Applicant: SpeciGen Inc.
    Inventors: Brian K. Campion, Marvin I. Siegel
  • PROTEIN CAGE IMMUNOTHERAPEUTICS
    Publication number: 20080311145
    Abstract: The present invention provides compositions of heat shock protein cages for use in therapeutic vaccines. The heat shock protein cages of the invention have attached antigen, located either on the interior or exterior of the protein cage, and optionally an adjuvant.
    Type: Application
    Filed: April 3, 2008
    Publication date: December 18, 2008
    Applicant: SpeciGen, Inc.
    Inventors: Brian K. Campion, Marvin I. Siegel
  • Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives
    Patent number: 5439916
    Abstract: Novel polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives are disclosed which are useful for treating allergic reactions, inflammation, peptic ulcers, hypertension, and hyperproliferative skin diseases and for suppressing the immune response in mammals. Methods for preparing said compounds are also disclosed.
    Type: Grant
    Filed: August 31, 1990
    Date of Patent: August 8, 1995
    Assignee: Schering Corporation
    Inventors: Ashit K. Ganguly, Richard J. Friary, John H. Schwerdt, Marvin I. Siegel, Sidney R. Smith, Edmund J. Sybertz
  • Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives
    Patent number: 5126352
    Abstract: Novel polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives are disclosed which are useful for treatment allergic reactions, inflammation, peptic ulcers, hypertension, and hyperproliferative skin diseases and for suppressing the immune response in mammals. Methods for preparing said compounds are also disclosed.
    Type: Grant
    Filed: August 31, 1990
    Date of Patent: June 30, 1992
    Assignee: Schering Corporation
    Inventors: Ashit K. Ganguly, Richard J. Friary, John H. Schwerdt, Marvin I. Siegel, Sidney R. Smith, Vera A. Seidl, Edmund J. Sybertz
  • Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives
    Patent number: 5116840
    Abstract: Novel polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives are disclosed which are useful for treating allergic reactions, inflammation, peptic ulcers, hypertension, and hyperproliferative skin diseases and for suppressing the immune response in mammals. Methods for preparing said compounds are also disclosed.
    Type: Grant
    Filed: August 31, 1990
    Date of Patent: May 26, 1992
    Assignee: Schering Corporation
    Inventors: Ashit K. Ganguly, Richard J. Friary, John H. Schwerdt, Marvin I. Siegel, Sidney R. Smith, Vera A. Seidl, Edmund J. Sybertz
  • Immune suppression method employing aryl-substituted naphthyridine and pyridopyrazine derivatives
    Patent number: 5045542
    Abstract: A method and composition for suppressing the immune response are disclosed which employ an immunosuppressing effective amount of certain aryl-substituted naphthyridines and pyrido-pyrazines.
    Type: Grant
    Filed: July 31, 1989
    Date of Patent: September 3, 1991
    Assignee: Schering Corporation
    Inventors: Marvin I. Siegel, Sidney R. Smith
  • 1-substituted naphthyridine and pyridopyrazine derivatives
    Patent number: 5037826
    Abstract: 1-Substituted naphthyridines and pyridopyrazines are disclosed which are useful in treating allergic reactions, inflammation, peptic uclers and hyperproliferative skin diseases and in suppressing the immune response in mammals. Pharmaceutical compositions and methods of treatment employing such compounds are also disclosed.
    Type: Grant
    Filed: December 18, 1986
    Date of Patent: August 6, 1991
    Assignee: Schering Corporation
    Inventors: David J. Blythin, Marvin I. Siegel, Sidney R. Smith
  • Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives
    Patent number: 4988705
    Abstract: Novel polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives are disclosed which are useful for treating allergic reactions, inflammation, peptic ulcers, hypertension, and hyperproliferative skin diseases and for suppressing the immune response in mammals. Methods for preparing said compounds are also disclosed.
    Type: Grant
    Filed: February 7, 1989
    Date of Patent: January 29, 1991
    Assignee: Schering Corporation
    Inventors: Ashit K. Ganguly, Richard J. Friary, John H. Schwerdt, Marvin I. Siegel, Sidney R. Smith, Vera A. Seidl, Edmund J. Sybertz
  • Method for suppressing the immune response
    Patent number: 4945095
    Abstract: A method and composition for suppressing the immune response are disclosed which employ an immunosuppressing effective amount of certain substituted spiro pyridine derivatives.
    Type: Grant
    Filed: December 12, 1985
    Date of Patent: July 31, 1990
    Inventors: Sidney R. Smith, Marvin I. Siegel
  • Naphthyridine derivatives and method for treating allergic reactions
    Patent number: 4916131
    Abstract: 1-Substituted naphthyridines and pyrido-pyrazines are disclosed which are useful in treating allergic reactions, inflammation, peptic ulcers and hyperproliferative skin diseases and in suppressing the immune response in mammals. Pharmaceutical compositions and methods of treatment employing such compounds are also disclosed.
    Type: Grant
    Filed: July 20, 1988
    Date of Patent: April 10, 1990
    Assignee: Schering Corporation
    Inventors: David J. Blythin, Marvin I. Siegel, Sidney R. Smith
  • Immune suppression method employing arly-substituted naphthyridine and pyridopyrazine derivatives
    Patent number: 4882332
    Abstract: A method and composition for suppressing the immune response are disclosed which employ an immunosuppressing effective amount of certain aryl-substituted naphthyridines and pyrido-pyrazines.
    Type: Grant
    Filed: October 20, 1986
    Date of Patent: November 21, 1989
    Assignee: Schering Corporation
    Inventors: Marvin I. Siegel, Sidney R. Smith
  • Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives
    Patent number: 4810708
    Abstract: Novel polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives are disclosed which are useful for treating allergic reactions, inflammation, peptic ulcers, hypertension, and hyperproliferative skin diseases and for suppressing the immune response in mammals. Methods for preparing said compounds are also disclosed.
    Type: Grant
    Filed: February 17, 1987
    Date of Patent: March 7, 1989
    Assignee: Schering Corporation
    Inventors: Ashit K. Ganguly, Richard J. Friary, John H. Schwerdt, Marvin I. Siegel, Sidney R. Smith, Vera A. Seidl, Edmund J. Sybertz
  • Method for suppressing the immune response
    Patent number: 4801589
    Abstract: A method and composition for suppressing the immune response are disclosed which employ an immunosuppressing effective amount of certain substituted quinoline, naphthyridine and pyrido-pyrazine derivatives.
    Type: Grant
    Filed: June 12, 1986
    Date of Patent: January 31, 1989
    Assignee: Schering Corporation
    Inventors: Sidney R. Smith, Marvin I. Siegel
  • Naphthyridine derivatives and method for treating allergic reactions
    Patent number: 4775686
    Abstract: 1-Substituted naphthyridines and pyrido-pyrazines are disclosed which are useful in treating allergic reactions, inflammation, peptic ulcers and hyperproliferative skin diseases and in suppressing the immune response in mammals. Pharmaceutical compositions and methods of treatment employing such compounds are also disclosed.
    Type: Grant
    Filed: December 18, 1986
    Date of Patent: October 4, 1988
    Assignee: Schering Corporation
    Inventors: David J. Blythin, Marvin I. Siegel, Sidney R. Smith
  • Pyrimidine derivatives having anti-allergy, anti-inflammatory and immuno suppressant activity
    Patent number: 4725596
    Abstract: Certain pyrimidine derivatives are useful in treating allergic, inflammatory and hyperproliferative skin diseases and in suppressing the immune response. Methods for preparing the compounds and methods for their use are also described.
    Type: Grant
    Filed: August 15, 1986
    Date of Patent: February 16, 1988
    Assignee: Schering Corporation
    Inventors: Richard J. Friary, Sidney R. Smith, Marvin I. Siegel
  • Method for suppressing the immune response
    Patent number: 4687774
    Abstract: A method and composition for suppressing the immune response are disclosed which employ an immunosuppressing effective amount of certain tricyclic naphthyridine or pyrido-pyrazine derivatives.
    Type: Grant
    Filed: March 10, 1986
    Date of Patent: August 18, 1987
    Assignee: Schering Corporation
    Inventors: Sidney R. Smith, Marvin I. Siegel
  • Method for modulating the immune response
    Patent number: 4666922
    Abstract: There is disclosed a method for immunomodulation employing as active agents certain substituted 1,8-naphthyridines and 1,5,8-azanaphthyridines.
    Type: Grant
    Filed: March 13, 1986
    Date of Patent: May 19, 1987
    Assignee: Schering Corporation
    Inventors: Sidney R. Smith, Marvin I. Siegel
  • Methods of inducing bronchodilation
    Patent number: 4564626
    Abstract: A method for producing bronchodilation in a mammal is disclosed. Composition for use in said method are also described.
    Type: Grant
    Filed: April 1, 1983
    Date of Patent: January 14, 1986
    Assignee: Schering Corporation
    Inventors: William Kreutner, Marvin I. Siegel
  • Substituted pyrazoline, and its use in treatment of gastro-intestinal disturbances
    Patent number: 4448783
    Abstract: A method of treatment of secretory diarrhea in mammals including man, comprising administration of a non-toxic anti-diarrheal amount of a compound of formula (I), ##STR1## wherein Ar is 3-trifluoromethylphenyl,R is hydrogen and R.sup.1 is selected from hydrogen and lower alkyl having 1 to 6 carbon atoms,or a pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable carrier therefor. The preferred formulations include those suitable for oral, rectal or parenteral administration, and the preferred dose is in the range of 0.5 to 500 mg/kg body weight of the compound, administered two or three times per day.
    Type: Grant
    Filed: May 17, 1982
    Date of Patent: May 15, 1984
    Assignee: Burroughs Wellcome Co.
    Inventor: Marvin I. Siegel