Patents by Inventor Marvin J. Slepian

Marvin J. Slepian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10299736
    Abstract: Methods, devices, and systems according to present principles provide ways to diagnose frailty and assess the severity of its clinical status—e.g., non-frail, pre-frail, and frail, especially as measured and quantified during activities of daily living. Systems and methods according to present principles objectively quantify physical activity behaviors and identify specific motor tasks, which indicate clinical frailty syndrome behaviors such as flopping, cautious-sitting, non-uniform walking fluctuations, cognitive decline, slowness, weakness, and exhaustion. Additionally, the systems and methods allow improved sensitivity and specificity of frailty identification by further assessing physiological parameters such as heart rate, respiration rate, and skin temperature in response to, or recovery from, specific activities.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: May 28, 2019
    Assignee: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Bijan Najafi, Saman Parvaneh, Martha Jane Mohler, David G. Armstrong, Mindy Joy Fain, Marvin J. Slepian
  • Publication number: 20190125220
    Abstract: Systems, methods and software products determine an overall motion and/or flexibility envelope for an individual. Movement and position data of the individual is captured and processed to generate an overall motion and/or flexibility envelope for the individual defining overall motion and/or flexibility of the individual. The systems include a flexibility server with memory and a processor adapted to receive movement and position data of the individual, a motion and/or flexibility analyzer, implemented as machine readable instructions stored in the memory and executed by the digital processor, capable of processing the movement and position data to generate an overall motion and/or flexibility envelope for the individual defining overall motion and/or flexibility of the individual.
    Type: Application
    Filed: June 16, 2017
    Publication date: May 2, 2019
    Applicant: Arizona Board of Regents on Behalf of the University of Arizona
    Inventor: Marvin J. Slepian
  • Publication number: 20190117129
    Abstract: Systems, methods, and software products determine an overall motion, flexibility and/or strength envelope for an individual. Force, movement and position data of the individual is captured and processed to generate an overall motion, flexibility and/or strength envelope for the individual that defines overall motion, flexibility and/or strength of the individual. The system includes a flexibility server with memory and a processor that are adapted to receive force, movement and position data of the individual. A motion, flexibility and/or strength analyzer of the system, implemented as machine readable instructions stored in the memory and executed by the digital processor, is capable of processing the force, movement and position data to generate an overall motion, flexibility and/or strength envelope for the individual that defines the overall motion, flexibility and/or strength of the individual.
    Type: Application
    Filed: June 16, 2017
    Publication date: April 25, 2019
    Applicant: Arizona Board of Regents on Behalf of the University of Arizona
    Inventor: Marvin J. Slepian
  • Publication number: 20190122767
    Abstract: Systems and methods detect changes in ability of an individual to perform an activity. The system includes a processor, a memory, a generic signature database having at least one signature that corresponds to the activity, a decryptor that identifies a current activity of the individual, a normal activity pattern database that includes a pattern of the activity previously determined for the individual, and an activity analyzer configured to compare performance of the current activity to previous performances of the activity to identify change in the performance, and to generate an alert indicating the change when the change is identified. Sensor data indicative of movement of the individual is processed to identify the current activity and performance of the current activity is compared to previous performances of the activity to identify change and an alert is generated to indicate the change in the ability of the individual to perform the activity.
    Type: Application
    Filed: June 16, 2017
    Publication date: April 25, 2019
    Inventor: Marvin J. Slepian
  • Patent number: 10226552
    Abstract: Methods, materials, devices, and systems for electropolymeric paving and sealing (ePEPS) are provided. The methods include delivering paving materials to an interior surface of a blood vessel, tissue lumen or other hollow space, delivering electronic components to the surface, and forming a conformal device that contains the paving material and the integrated electronic components. Integrated electronic components can be homogenously or heterogeneously distributed in the material, such as on the top, middle, and/or bottom of the polymeric material. The devices are biocompatible, and preferably biodegradable or bioerodible. The devices integrated electrical properties useful for sensing or detecting one or more analytes, signals or conditions, transmitting or generating a signal, or releasing a therapeutic, prophylactic or diagnostic agent. Optionally, the devices are smart devices that include feedback and logic means to respond to a change in local conditions.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: March 12, 2019
    Assignee: Arizona Board of Regents on Behalf of the Unviersity of Arizona
    Inventor: Marvin J. Slepian
  • Publication number: 20190013093
    Abstract: Systems, methods, and software products analyze healthcare data. First input data is collected from a first source and second input data is collected from a second source disparate from the first source. The second source has a data format that is different from a format of the first source. The first input data is processed to determine a first concept and the second input data is processed to determine a second concept. A relationship between the first and second concepts is determined. The first and second concepts are stored within a knowledgebase based upon the relationship and a patient medical model is generated from the knowledgebase.
    Type: Application
    Filed: July 20, 2016
    Publication date: January 10, 2019
    Inventors: Marvin J. Slepian, Fuad Rahman, Arijit Mitra
  • Patent number: 10137306
    Abstract: Materials and systems that enable high efficiency conversion of mechanical stress to electrical energy and methods of use thereof are described herein. The materials and systems are preferably used to provide power to medical devices implanted inside or used outside of a patient's body. For medical devices, the materials and systems convert electrical energy from the natural contractile and relaxation motion of a portion of a patient's body, such as the heart, lung and diaphragm, or via motion of body materials or fluids such as air, blood, urine, or stool. The materials and systems are capable of being bent, folded or otherwise stressed without fracturing and include piezoelectric materials on a flexible substrate. The materials and systems are preferably fashioned to be generally conformal with intimate apposition to complex surface topographies.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: November 27, 2018
    Assignees: The Arizona Board of Regents on Behalf of The University of Arizona, The Board of Trustees of The University of Illinois
    Inventors: Canan Dagdeviren, John A. Rogers, Marvin J. Slepian
  • Publication number: 20180292888
    Abstract: Virtual reality system and method improve clinical outcomes. The virtual reality system includes a virtual display device capable of providing virtual reality images to a patient; one or more actuators capable of providing physical experience to the patient; and a controller. The controller is capable of: automatically selecting a treatment model based upon one or both of (a) a received identity of a medical treatment applied to the patient and (b) a received identity of a targeted disease of the patient; and coordinating the virtual display device and the one or more actuators to provide a synchronized immersive virtual reality environment for the patient to experience based upon the treatment model.
    Type: Application
    Filed: October 12, 2016
    Publication date: October 11, 2018
    Inventors: Marvin J. Slepian, Syed Hossainy, Fuad Rahman
  • Publication number: 20180280696
    Abstract: A sensor interface device (e.g., orthotic device or immobilization device) is disclosed. More specifically, described is an individualized sensor device and system to prevent tissue damage resulting from, for example, pressure, torsion, temperature, shear, altered blood flow, reduced oxygen tension, pH levels, tissue conductivity, tissue viscoelasticity, infection and sweat chloride levels. In particular embodiments, the systems, devices and related methods are used for preventing ambulation and mobility related plantar tissue related damage and immobilizing tissues.
    Type: Application
    Filed: September 23, 2016
    Publication date: October 4, 2018
    Inventors: Marvin J. Slepian, David G. Armstrong, Bijan Najafi
  • Publication number: 20180258207
    Abstract: Polymers having mechanical properties approaching or exceeding commercial elastomers and engineering thermoplastics, but improved biostability, are described herein. In one embodiment, the polymers have a hard segment containing one or more disulfoxide or disulfone moieties and a soft segment connected to the hard segment to form an elastomeric polymer. The polymer is resistant to oxidation and/or hydrolytic degradation, particularly in vivo, which allows for the use of these materials in implants/devices which are implanted for an extended period of time. The ratio or percentage by weight of soft segment to hard segment can be varied based on the physical and mechanical properties of the desired device.
    Type: Application
    Filed: September 19, 2016
    Publication date: September 13, 2018
    Inventors: Arthur J. Coury, Marvin J. Slepian
  • Publication number: 20180226141
    Abstract: A patient coordination system, method and software product receives configuration of a hospital within a server. A hospital model is determined based upon the configuration. Location of each patient within the hospital is received. A course through hospital for each patient is received. Status for each patient is received from independently run hospital services. Progress of each patient through the corresponding course is determined and a dashboard showing the hospital model with spatial indication of the progress for each patient is generated.
    Type: Application
    Filed: July 20, 2016
    Publication date: August 9, 2018
    Inventors: Marvin J. Slepian, Fuad Rahman
  • Publication number: 20180211730
    Abstract: A medical feedback continuum systems, method, and software product processes healthcare data of a plurality of patients collected from disparate sources to determine a patient medical model of one of the plurality of patients. A medical intensity status is generated from the patient medical model and displayed to a doctor during a consultation of the doctor with the one patient. Healthcare information is collected during the consultation and processed to determine an intended intervention prescribed by the doctor for the one patient. An outcome of the intervention is predicted based upon analytics of the patient medical model, and whether the predicted outcome of the intervention is favorable for the one patient is determined.
    Type: Application
    Filed: July 20, 2016
    Publication date: July 26, 2018
    Applicant: Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Marvin J. Slepian, Fuad Rahman, Syed Hossainy
  • Publication number: 20180103852
    Abstract: Materials and devices are provided for the sensing and manipulation of biomechanical and physiochemical properties of tissues or tissue surfaces. Examples of use include soft tissues such as skin or adipose tissues or more dense tissues such as muscle or heart or dense tissues such as bone. The materials and devices provide for in vivo measurements of biomechanical properties at the tissue surface, e.g. near surface regions of the epidermis or dermis or underlying structures. The devices can be non-invasive and/or non-destructive to the material and, especially for the biomaterials, can be biocompatible and/or biodegradable. The materials and devices can use ultrathin, stretchable networks of mechanical actuators and sensors constructed with nanoribbons of piezoelectric materials.
    Type: Application
    Filed: April 17, 2016
    Publication date: April 19, 2018
    Inventors: CANAN DAGDEVIREN, JOHN A. ROGERS, MARVIN J. SLEPIAN
  • Publication number: 20170303855
    Abstract: Electronic devices and systems that overcome the limitation of stiffness and rigidity generally associated with electronics and allow for delivery via minimally invasive or percutaneous access and delivery systems are described herein. The devices and systems are able to change in size, such as from a larger electronic construct to a smaller flowable configuration. The devices and systems are configured to open or reconfigure to return to the original size and spatial dimensions at the site. In another embodiment, the devices and systems begin as a plurality of discrete electrical elements in a flowable state, and change to a non-fluent state thereby forming an electrical construct. The electrical elements are able to communicate by direct contact with each other or near field inter-device communication means. This allows the electronic device or system to be applied, adhere and conform to the underlying surface.
    Type: Application
    Filed: October 8, 2015
    Publication date: October 26, 2017
    Inventor: Marvin J. Slepian
  • Publication number: 20170299571
    Abstract: Provided herein are systems and method for measuring cell stiffness. In particular, provided herein are microelectrode configuration and systems for measuring platelet deformation and stiffness.
    Type: Application
    Filed: April 14, 2017
    Publication date: October 19, 2017
    Inventors: Marvin J. Slepian, Sui Ling Leung
  • Publication number: 20170246632
    Abstract: Provided herein is technology relating to microfluidic devices and particularly, but not exclusively, to devices, methods, systems, and kits for imparting stresses on a fluid flowing through a microfluidic device that is designed to mimic a stress profile of a macrofluidic device or pathology.
    Type: Application
    Filed: August 28, 2015
    Publication date: August 31, 2017
    Inventors: Marvin J. Slepian, Alberto C. Redaelli, Marco Rasponi, Danny Bluestein
  • Publication number: 20170245989
    Abstract: A polymeric valve which may include a heart valve, and also may include a trileaflet heart valve includes a stent having a base and a plurality of outwardly extending posts from the base and equidistant from each other. A plurality of leaflets each connected to a corresponding one of the posts at one end, and each of the leaflets connected to the base. Each of the leaflets having an operative end opposite the end connected to the post, and the operative ends of the leaflets being biased in a closed position such that the operative ends abut each other. The operative ends are configured to rhythmically open and close in relation to each other, and the leaflets include multiple cross sectional thicknesses at different portions of the leaflets.
    Type: Application
    Filed: April 20, 2017
    Publication date: August 31, 2017
    Applicants: The Research Foundation for The State University of New York, The Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Danny Bluestein, Thomas E. Claiborne, Marvin J. Slepian
  • Patent number: 9655720
    Abstract: A polymeric valve which may include a heart valve, and also may include a trileaflet heart valve includes a stent having a base and a plurality of outwardly extending posts from the base and equidistant from each other. A plurality of leaflets each connected to a corresponding one of the posts at one end, and each of the leaflets connected to the base. Each of the leaflets having an operative end opposite the end connected to the post, and the operative ends of the leaflets being biased in a closed position such that the operative ends abut each other. The operative ends are configured to rhythmically open and close in relation to each other, and the leaflets include multiple cross sectional thicknesses at different portions of the leaflets.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: May 23, 2017
    Assignees: The Research Foundation for The State University of New York, The Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Danny Bluestein, Thomas E. Claiborne, Marvin J. Slepian
  • Publication number: 20170007552
    Abstract: Methods, compositions, and devices to limit, modulate, insulate, and/or otherwise alter the effects of exogenous physical stimuli on cells are described herein. The cells may be removed from the body, preferably isolated, and treated ex vivo with the composition to limit the effects of physical stimuli on the cells and then returned to the patient. Alternatively, the cells may be treated in vivo. The compositions can be administered a variety of manners, such as systemically, locally or regionally.
    Type: Application
    Filed: January 26, 2015
    Publication date: January 12, 2017
    Inventor: Marvin J. Slepian
  • Publication number: 20160346556
    Abstract: Materials and systems that enable high efficiency conversion of mechanical stress to electrical energy and methods of use thereof are described herein. The materials and systems are preferably used to provide power to medical devices implanted inside or used outside of a patient's body. For medical devices, the materials and systems convert electrical energy from the natural contractile and relaxation motion of a portion of a patient's body, such as the heart, lung and diaphragm, or via motion of body materials or fluids such as air, blood, urine, or stool. The materials and systems are capable of being bent, folded or otherwise stressed without fracturing and include piezoelectric materials on a flexible substrate. The materials and systems are preferably fashioned to be generally conformal with intimate apposition to complex surface topographies.
    Type: Application
    Filed: January 13, 2015
    Publication date: December 1, 2016
    Inventors: Marvin J. Slepian, Canan Dagdeviren, John A. Rogers